INT70896

Context Info Confidence 0.65 First Reported 1997 Last Reported 2010 Negated 1 Speculated 2 Reported most in Body Documents 48 Total Number 50 Disease Relevance 33.55 Pain Relevance 8.39

extracellular region (PDGFB) cytoplasm (PDGFB)

Anatomy Link Frequency platelet 7 lung 4 endothelial cells 2 SSV 1 pericytes 1 PDGFB (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 229 100.00 Chronic pancreatitis 30 99.80 fibrosis 384 99.56 Inflammation 208 99.04 chemokine 297 98.82 Glutamate 22 97.86 Angina 8 96.36 anesthesia 15 91.52 antagonist 42 91.36 cINOD 22 89.04

Disease Link Frequency Relevance Heat Glioma 189 99.84 Glioblastoma 42 99.84 Pancreatitis 36 99.80 Cancer 1004 99.62 Pulmonary Fibrosis 177 99.56 Infection 237 99.52 Cytomegalovirus Infection 312 99.32 Desmoid Disease 84 99.28 Disease 148 99.20 Hypertrophic Cardiomyopathy 5 99.18

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This work showed that becaplermin gel 100 ?

Gene_expression (gel) of becaplermin

1) Confidence 0.65 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.48 Pain Relevance 0

Indeed, becaplermin gel 100 ?

Gene_expression (gel) of becaplermin

2) Confidence 0.65 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.66 Pain Relevance 0

D’Hemercourt and colleagues (1998) compared three treatment regimens, ie, good wound care alone (N = 68), topical carboxymethylcellulose gel (N = 70), and becaplermin gel 100 ?

Gene_expression (gel) of becaplermin associated with injury

3) Confidence 0.65 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546468 Disease Relevance 0.64 Pain Relevance 0

The expression of PDGFs and type beta PDGF receptor was examined in the normal human pancreas and in chronic pancreatitis, a fibrotic disease associated with fibroblastic proliferation, atrophy, and acinar cell dedifferentiation.

Spec (examined) Gene_expression (expression) of PDGF in acinar cell associated with fibrosis, frailty, disease and chronic pancreatitis

4) Confidence 0.64 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.61 Pain Relevance 0.23

Overexpression of platelet-derived growth factor (PDGF) B chain and type beta PDGF receptor in human chronic pancreatitis.

Gene_expression (Overexpression) of PDGF in platelet associated with chronic pancreatitis

5) Confidence 0.64 Published 1998 Journal Dig. Dis. Sci. Section Title Doc Link 9539653 Disease Relevance 0.72 Pain Relevance 0.31

The concomitant overexpression of PDGFs and of the type beta PDGF receptor points to the existence of autocrine and paracrine PDGF-dependent loops in human chronic pancreatitis.

Gene_expression (overexpression) of PDGF associated with chronic pancreatitis

6) Confidence 0.64 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.74 Pain Relevance 0.41

In chronic pancreatitis tissues, PDGF and type beta PDGF receptor immunoreactivity were present in acinar, ductal, islet, and endothelial cells, fibroblasts, and leukocytes.

Gene_expression (present) of PDGF in leukocytes associated with chronic pancreatitis

7) Confidence 0.63 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.69 Pain Relevance 0.41

Most cases of DFSP feature a specific translocation of chromosomes 17 and 22, which results in constitutive production of platelet-derived growth factor B chain (PDGFB) and stimulation of DFSP growth.

Gene_expression (production) of PDGFB in platelet

8) Confidence 0.62 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2892497 Disease Relevance 0.31 Pain Relevance 0

Augmented expression of PDGF is further observed in asbestos-, bleomycin- and idiopathic pulmonary fibrosis [71-73].

Gene_expression (expression) of PDGF associated with fibrosis and pulmonary fibrosis

9) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.11 Pain Relevance 0.45

Firstly, PDGF and PDGFR are expressed at low levels in normal adults, while elevated levels are detected in lungs of patients with radiation-induced pulmonary fibrosis [70].

Gene_expression (expressed) of PDGF in lungs associated with fibrosis and pulmonary fibrosis

10) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.25 Pain Relevance 0.52

Savikko and his colleagues also showed that limiting the extent of inflammation by cyclosporin A treatment did not inhibit the expression of PDGF ligands and receptors [87].

Gene_expression (expression) of PDGF associated with inflammation

11) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.59 Pain Relevance 0.18

A number of investigations provided clear evidence for increased expression of various cytokines including PDGF, transforming growth factor-?

Gene_expression (expression) of PDGF associated with cytokine

12) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.51 Pain Relevance 0.56

Increased expression of PDGF in rat lungs by adenoviral delivery or lung-specific over-expression in mice is associated with pronounced lung fibrosis [74,75].

Gene_expression (expression) of PDGF in lung associated with fibrosis and pulmonary fibrosis

13) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.00 Pain Relevance 0.41

In gliomas, analysis of PDGF/PDGFR expression suggested the presence of autocrine and paracrine loops of PDGF in glioma activating PDGFR-?

Gene_expression (expression) of PDGF associated with glioma

14) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.03 Pain Relevance 0.03

Likewise, overexpression of PDGF and c-kit was also observed in Leydig tumors.

Gene_expression (overexpression) of PDGF associated with cancer

15) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.90 Pain Relevance 0

On the other hand, it was shown that tumor cells are able to produce pro-angiogenic cytokines including VEGF, PDGF and FGF in response to ionising radiation.

Gene_expression (produce) of PDGF associated with cancer and cytokine

16) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.73 Pain Relevance 0.10

The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.

Gene_expression (overexpression) of PDGF in lungs

17) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.98 Pain Relevance 0.28

It has been suggested that pirfenidone and interferon gamma, both ameliorate lung fibrosis by downregulation of PDGF expression [72,90].

Gene_expression (expression) of PDGF in lung associated with fibrosis and pulmonary fibrosis

18) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.29 Pain Relevance 0.15

Overexpression of PDGF were observed in desmoid tumors, while inhibition of PDGF signaling by imatinib induced overall 1 year tumor control rate of 36.8% in a phase II clinical study [15].

Gene_expression (Overexpression) of PDGF associated with cancer and desmoid disease

19) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.78 Pain Relevance 0.06

-granules of platelets are a major storage site for PDGF, recent studies have shown that PDGF can be synthesized by a number of different cell types such as macrophages, epithelial and endothelial cells [5-8].

Gene_expression (synthesized) of PDGF in platelets

20) Confidence 0.41 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.38 Pain Relevance 0.04

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