INT70897

Context Info Confidence 0.57 First Reported 1997 Last Reported 2010 Negated 0 Speculated 2 Reported most in Body Documents 15 Total Number 17 Disease Relevance 13.04 Pain Relevance 3.52

extracellular region (PDGFB) cytoplasm (PDGFB)

Anatomy Link Frequency platelet 6 lungs 6 hearts 2 PDGFB (Homo sapiens)

Pain Link Frequency Relevance Heat cytokine 81 100.00 fibrosis 136 99.72 Chronic pancreatitis 10 98.12 Angina 2 96.36 chemokine 108 90.00 Inflammation 76 89.60 cINOD 8 89.44 isoflurane 4 88.64 anesthesia 5 87.76 bradykinin 4 76.48

Disease Link Frequency Relevance Heat Glioma 72 99.72 Pulmonary Fibrosis 64 99.72 Hypertrophic Cardiomyopathy 5 99.48 Coronary Heart Disease 5 99.34 Desmoid Disease 32 99.28 Cancer 363 98.96 Fibrosis 154 98.84 Brain Tumor 32 98.64 Pancreatitis 12 98.12 Cv Unclassified Under Development 5 97.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Overexpression of platelet-derived growth factor (PDGF) B chain and type beta PDGF receptor in human chronic pancreatitis.

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PDGF in platelet associated with chronic pancreatitis

1) Confidence 0.57 Published 1998 Journal Dig. Dis. Sci. Section Title Doc Link 9539653 Disease Relevance 0.72 Pain Relevance 0.31

Most cases of DFSP feature a specific translocation of chromosomes 17 and 22, which results in constitutive production of platelet-derived growth factor B chain (PDGFB) and stimulation of DFSP growth.

Positive_regulation (results) of Gene_expression (production) of PDGFB in platelet

2) Confidence 0.56 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2892497 Disease Relevance 0.31 Pain Relevance 0

The concomitant overexpression of PDGFs and of the type beta PDGF receptor points to the existence of autocrine and paracrine PDGF-dependent loops in human chronic pancreatitis.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF associated with chronic pancreatitis

3) Confidence 0.41 Published 1998 Journal Dig. Dis. Sci. Section Abstract Doc Link 9539653 Disease Relevance 0.74 Pain Relevance 0.41

The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF in lungs

4) Confidence 0.37 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.98 Pain Relevance 0.28

Likewise, overexpression of PDGF and c-kit was also observed in Leydig tumors.

Positive_regulation (overexpression) of Gene_expression (overexpression) of PDGF associated with cancer

5) Confidence 0.37 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.90 Pain Relevance 0

Increased expression of PDGF in rat lungs by adenoviral delivery or lung-specific over-expression in mice is associated with pronounced lung fibrosis [74,75].

Positive_regulation (Increased) of Gene_expression (expression) of PDGF in lung associated with fibrosis and pulmonary fibrosis

6) Confidence 0.37 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.00 Pain Relevance 0.41

Augmented expression of PDGF is further observed in asbestos-, bleomycin- and idiopathic pulmonary fibrosis [71-73].

Positive_regulation (Augmented) of Gene_expression (expression) of PDGF associated with fibrosis and pulmonary fibrosis

7) Confidence 0.37 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.12 Pain Relevance 0.45

Overexpression of PDGF were observed in desmoid tumors, while inhibition of PDGF signaling by imatinib induced overall 1 year tumor control rate of 36.8% in a phase II clinical study [15].

Positive_regulation (Overexpression) of Gene_expression (Overexpression) of PDGF associated with cancer and desmoid disease

8) Confidence 0.37 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.78 Pain Relevance 0.06

In order to investigate the effect of PDGF release rate on PDGF biological function in vivo, nine groups of 3 animals each were prepared to test in a rat wound healing model. [24] They were grouped as follows:

Spec (investigate) Positive_regulation (on) of Spec (investigate) Gene_expression (biological) of PDGF associated with wound healing

9) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.10 Pain Relevance 0.13

Thus, the controlled delivery of PDGF will likely be critical for clinical success.[36]

Positive_regulation (delivery) of Gene_expression (delivery) of PDGF

10) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0.06 Pain Relevance 0.27

In parallel with the 1 week histological observations, the histomorphometry measurement results of 1 week specimens in Fig. 2 showed that the areas representing the specimen volume were significantly greater in the groups of NFS containing PDGF encapsulated in HMW MS and high dose PDGF encapsulated in LMW microspheres than the other groups.

Positive_regulation (encapsulated) of Gene_expression (containing) of PDGF

11) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0

A number of investigations provided clear evidence for increased expression of various cytokines including PDGF, transforming growth factor-?

Positive_regulation (increased) of Gene_expression (expression) of PDGF associated with cytokine

12) Confidence 0.27 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.52 Pain Relevance 0.56

The radiation-induced overexpression of PDGF led to phosphorylation and activation of PDGFR in lungs of irradiated mice, while the phosphorylation of PDGFR was strongly inhibited in both irradiated groups treated with RTKIs.

Positive_regulation (induced) of Gene_expression (overexpression) of PDGF in lungs

13) Confidence 0.27 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 0.99 Pain Relevance 0.28

In gliomas, analysis of PDGF/PDGFR expression suggested the presence of autocrine and paracrine loops of PDGF in glioma activating PDGFR-?

Positive_regulation (/) of Gene_expression (expression) of PDGF associated with glioma

14) Confidence 0.27 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1780053 Disease Relevance 1.03 Pain Relevance 0.03

In parallel with the 1 week histological observations, the histomorphometry measurement results of 1 week specimens in Fig. 2 showed that the areas representing the specimen volume were significantly greater in the groups of NFS containing PDGF encapsulated in HMW MS and high dose PDGF encapsulated in LMW microspheres than the other groups.

Positive_regulation (encapsulated) of Gene_expression (containing) of PDGF

15) Confidence 0.25 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2248711 Disease Relevance 0 Pain Relevance 0

However, strong evidence suggests that promotion of VSM growth is mediated by local production of platelet growth factor (PGF) and ANG-II (Williams 1998).

Positive_regulation (mediated) of Gene_expression (production) of platelet growth factor in platelet

16) Confidence 0.03 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2350146 Disease Relevance 0.85 Pain Relevance 0.22

To investigate involvement of growth factors on myocardial hypertrophy in HCM patients, we evaluated gene expression and cellular localization of transforming growth factor-beta1 (TGF-beta1), insulin-like growth factors (IGF-I and IGF-II), and platelet-derived growth factor-B (PDGF-B) in ventricular biopsies obtained from patients with HCM (n=8), aortic stenosis (AS) (n=8), or stable angina (SA) (n=8) and from explanted hearts with ischemic cardiomyopathy (TM) (n=7).

Spec (investigate) Positive_regulation (evaluated) of Gene_expression (expression) of PDGF-B in hearts associated with angina, hypertrophic cardiomyopathy, cv unclassified under development and coronary heart disease

17) Confidence 0.02 Published 1997 Journal Circulation Section Abstract Doc Link 9264495 Disease Relevance 0.94 Pain Relevance 0.10

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