INT7090

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Context Info
Confidence 0.66
First Reported 1982
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 50
Total Number 50
Disease Relevance 13.54
Pain Relevance 8.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
body 4
brain 3
capillary 2
plasma 1
tail 1
pcp (Mus musculus)
Pain Link Frequency Relevance Heat
ketamine 58 100.00 Very High Very High Very High
cocaine 35 100.00 Very High Very High Very High
Central nervous system 4 100.00 Very High Very High Very High
Delta-9-tetrahydrocannabinol 3 100.00 Very High Very High Very High
Paracetamol 1 99.90 Very High Very High Very High
Dopamine 65 99.84 Very High Very High Very High
Neurobehavioral 108 99.64 Very High Very High Very High
Analgesic 7 99.64 Very High Very High Very High
Thalamus 54 99.30 Very High Very High Very High
Pain 43 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pneumocystis Pneumonia 168 100.00 Very High Very High Very High
Schizophrenia 15 100.00 Very High Very High Very High
Psychosis 6 100.00 Very High Very High Very High
Catalepsy 4 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 77 99.98 Very High Very High Very High
Poisoning 10 99.96 Very High Very High Very High
Body Weight 234 99.84 Very High Very High Very High
Pulmonary Disease 90 99.48 Very High Very High Very High
Influenza Virus Infection 82 99.36 Very High Very High Very High
Disease 184 99.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings support and extend prior work by Wang et al., [8], [9], who reported that exposing female rat pups to PCP on three postnatal days (P7+P9+P11) slowed acquisition of a delayed spatial alternation task when testing began on P42.
Gene_expression (exposing) of PCP
1) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.10 Pain Relevance 0.09
In contrast, PCP exposure on P7 resulted in dense AC3 staining in all divisions of the neocortex, while staining in the hippocampus, hypothalamus and amygdala was much less prominent.
Gene_expression (exposure) of PCP in amygdala associated with hippocampus and amygdala
2) Confidence 0.66 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.07 Pain Relevance 0.28
The PCP is comprised of an in-patient acute care unit, an in-hospital consultation service and offers home consultation services and an oncology outpatient clinic consultation service.
Gene_expression (comprised) of PCP
3) Confidence 0.58 Published 2006 Journal BMC Palliat Care Section Body Doc Link PMC1557663 Disease Relevance 0.17 Pain Relevance 0.09
In summary, small differences may have existed between P2+P7 PCP-treated and control mice during the cued trials resulting in transient performance deficits suggesting that mild non-associative disturbances in the PCP-treated mice (e.g., visual or sensorimotor disturbances, altered motivation) may have briefly affected performance although the two groups eventually performed at approximately equal levels.
Gene_expression (existed) of PCP-treated
4) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0 Pain Relevance 0
In addition, since the developing human brain may be subjected to multiple PCP exposures during synaptogenesis, we also studied the potential long-term functional deficits of mice exposed to PCP during the two periods of vulnerability (P2 and P7).


Gene_expression (exposures) of PCP in brain
5) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.09 Pain Relevance 0.10
However, mice exposed to PCP on P7 exhibited significantly less freezing in response to the tone during the auditory cue test compared to saline controls [F(1,28)?
Gene_expression (exposed) of PCP
6) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.43 Pain Relevance 0.08
In addition, Wang and colleagues focused on the effects of PCP exposure that occurred later during the developmental period of synaptogenesis (P7, 9 and 11) while our study examined the effects of PCP-induced neuroapoptosis at earlier ages (P2 and 7) to determine the different patterns of neuroapoptosis that occur following single or double dosing regimens during this time.
Gene_expression (exposure) of PCP
7) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.07 Pain Relevance 0.13
In contrast to the small effects of P2+P7 PCP treatment on cued trials performance, PCP-treated animals showed robust and significant acquisition deficits during the place condition of the water maze at P30 (Fig. 4B), [Group main effect: F (1,56)?
Gene_expression (animals) of PCP-treated
8) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0 Pain Relevance 0
Effects of PCP on Body Weight
Gene_expression (Effects) of PCP in Body associated with body weight
9) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.16 Pain Relevance 0.06
Rather the increased staining in the P2+P7 animals indicates that PCP exposure at P2 has produced alterations in the brain that result in it being more susceptible to the apoptotic effects of PCP at P7.
Gene_expression (exposure) of PCP in brain associated with apoptosis
10) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.26 Pain Relevance 0.15
Analysis of absolute body weights measured at (P60) showed no significant differences among PCP-treated animals and controls (Fig. 3C).


Gene_expression (animals) of PCP-treated in body associated with body weight
11) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.81 Pain Relevance 0
Our finding that exposure of infant mice to PCP on two occasions causes much more severe neurobehavioral impairments than PCP exposure on only one occasion, may have relevance in a public health context.
Gene_expression (exposure) of PCP associated with neurobehavioral
12) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.36 Pain Relevance 0.42
In addition, the groups of mice that were subjected to single exposures of PCP on either P2 or P7 had significantly decreased body weights for similar periods of time but showed little or no disturbances in learning and memory performance in the above-mentioned behavioral tests.
Gene_expression (exposures) of PCP in body associated with cognitive disorder and body weight
13) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.71 Pain Relevance 0.04
However, although no differences between groups were found for platform crossings in the 1 hr delay probe trial on day 5, the control mice exhibited a significant spatial bias for the target quadrant, (p<0.007 for target vs each of the other quadrants), while the PCP-treated group did not (Fig. 4F).
Gene_expression (group) of PCP-treated
14) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0 Pain Relevance 0
Dense AC3 staining was found in the anterior and laterodorsal nuclei of the thalamus and the caudate/putamen following PCP exposure on each of these postnatal days.
Gene_expression (exposure) of PCP in putamen associated with thalamus
15) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.15 Pain Relevance 0.27
One male and one female pup from each litter received an injection of 50 mg/kg of PCP on P7.
Gene_expression (injection) of PCP
16) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0 Pain Relevance 0.08
In the present study we have demonstrated that robust spatial learning and memory deficits occur in mice that were subjected to two PCP exposures (i.e., on P2+P7) but not as a result of a single exposure on P2 or P7, and that these impairments are likely to be permanent in nature and encompass non-spatial forms of learning as well.
Gene_expression (exposures) of PCP
17) Confidence 0.58 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894063 Disease Relevance 0.09 Pain Relevance 0.08
The following monohydroxy derivatives of 1-(1-phenylcyclohexyl)piperidine (phencyclidine, PCP) were synthesized: o-, m-, and p-phenols of PCP, 1-(1-phenylcyclohexyl)-4-piperidinol, and two stereoisomeric pairs of 3-phenyl-3-(1-piperidinyl)cyclohexanol and 4-phenyl-4-(1-piperidinyl)cyclohexanol.
Gene_expression (synthesized) of PCP
18) Confidence 0.52 Published 1982 Journal J. Med. Chem. Section Abstract Doc Link 6279847 Disease Relevance 0 Pain Relevance 0.08
PCP (3-100 microM) and all central nervous system stimulants tested produced a concentration-dependent increase of basal [3H]DA release (potency order: amfonelic acid, amphetamine greater than nomifensine, methylphenidate greater than PCP).
Gene_expression (produced) of PCP in central nervous system associated with dopamine, central nervous system and potency
19) Confidence 0.52 Published 1982 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6128403 Disease Relevance 0 Pain Relevance 0.65
When cumulative dose-effect curves were determined for other drugs substituted for PCP, pigeons responded predominantly on the PCP key after other doses of PCP, ketamine, pentobarbital, d-cyclazocine and l-cyclazocine, but not after saline, lactic acid solution, d-amphetamine, chlordiazepoxide, scopolamine, morphine, naltrexone, or d-, or l-methadone. l-Cyclazocine was slightly more potent than d-cyclazocine in producing PCP key responding.
Gene_expression (producing) of PCP associated with ketamine, methadone and morphine
20) Confidence 0.52 Published 1982 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6817368 Disease Relevance 0 Pain Relevance 0.24

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