INT70918

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Context Info
Confidence 0.45
First Reported 1996
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.79
Pain Relevance 2.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng) extracellular region (Ifng)
Anatomy Link Frequency
thymocytes 4
spleen 2
Ifng (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 6 100.00 Very High Very High Very High
Demyelination 2 99.12 Very High Very High Very High
Opioid 2 98.52 Very High Very High Very High
Sciatic nerve 2 97.92 Very High Very High Very High
alcohol 14 97.00 Very High Very High Very High
Dynorphin 1 95.36 Very High Very High Very High
cocaine 4 95.28 Very High Very High Very High
Morphine 4 94.84 High High
Inflammation 5 94.72 High High
Neuritis 6 91.60 High High
Disease Link Frequency Relevance Heat
Demyelinating Disease 2 99.12 Very High Very High Very High
Cancer 4 97.04 Very High Very High Very High
INFLAMMATION 4 94.72 High High
Targeted Disruption 4 93.64 High High
Increased Venous Pressure Under Development 3 91.84 High High
Experimental Autoimmune Neuritis 5 91.60 High High
Disorder Of Lipid Metabolism 1 90.32 High High
Bacterial Infection 1 81.76 Quite High
Disease 5 81.72 Quite High
Hematological Disease 2 75.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-18 is a proinflammatory cytokine of the IL-1 family, recognized for its ability to promote IFN-gamma secretion.
Positive_regulation (promote) of Localization (secretion) of IFN-gamma associated with cytokine
1) Confidence 0.45 Published 2005 Journal Int. J. Cardiol. Section Abstract Doc Link 15676165 Disease Relevance 0.88 Pain Relevance 0.58
The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice splenocytes and thymocytes depended on the presence of the oncogene product, on the in vivo pretreatment with alcohol, or on the in vitro treatment with cocaine or morphine.
Positive_regulation (depended) of Localization (secretion) of IFN-gamma in thymocytes associated with morphine, cocaine and alcohol
2) Confidence 0.42 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.27 Pain Relevance 0.33
The objective of this paper was to learn if the in vitro secretion of IL-2 and IFN-gamma and the release of sIL-2R by Oncomice splenocytes and thymocytes depended on the presence of the oncogene product, on the in vivo pretreatment with alcohol, or on the in vitro treatment with cocaine or morphine.
Positive_regulation (depended) of Localization (release) of IFN-gamma in thymocytes associated with morphine, cocaine and alcohol
3) Confidence 0.42 Published 2001 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 11792018 Disease Relevance 0.26 Pain Relevance 0.33
However, numbers of IFN-gamma-secreting cells from the spleen were significantly augmented in the IFN-gammaR(-/-) mice, reflecting a failure of negative feedback circuits.
Positive_regulation (augmented) of Localization (ecreting ) of IFN-gamma in spleen
4) Confidence 0.32 Published 2001 Journal Exp. Neurol. Section Abstract Doc Link 11358460 Disease Relevance 1.07 Pain Relevance 0.74
Activation of melatonin receptors enhances the release of Th cell cytokines, such as gamma-interferon and interleukin-2, as well as novel opioid cytokines which cross-react immunologically with both interleukin-4 and dynorphin B.
Positive_regulation (enhances) of Localization (release) of gamma-interferon associated with dynorphin, opioid and cytokine
5) Confidence 0.10 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 9266542 Disease Relevance 0.31 Pain Relevance 0.35

General Comments

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