INT70919

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Context Info
Confidence 0.36
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 19
Total Number 20
Disease Relevance 6.58
Pain Relevance 3.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
T lymphocytes 3
macrophages 2
placenta 2
embryos 1
T-helper cell 1
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 615 100.00 Very High Very High Very High
Inflammation 329 99.84 Very High Very High Very High
Dynorphin 2 99.80 Very High Very High Very High
Opioid 9 99.66 Very High Very High Very High
Crohn's disease 10 93.56 High High
Kappa opioid receptor 4 76.32 Quite High
opioid receptor 1 75.00 Quite High
Inflammatory response 39 54.40 Quite High
agonist 7 50.00 Quite Low
dexamethasone 12 36.00 Quite Low
Disease Link Frequency Relevance Heat
INFLAMMATION 368 99.84 Very High Very High Very High
Encephalitis 2 98.92 Very High Very High Very High
Adhesions 11 97.40 Very High Very High Very High
Infection 551 96.76 Very High Very High Very High
Cold Sores 428 96.36 Very High Very High Very High
Thymoma 2 95.68 Very High Very High Very High
Cancer 68 93.88 High High
Inflammatory Bowel Disease 18 93.88 High High
Disease 117 93.56 High High
Apoptosis 108 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
B- and T lymphocytes and macrophages were eliminated from bone marrow cells, which were cultured at 37°C for 7 days in 5% FCS-containing RPMI medium complemented with GM-CSF and IL-4 (200 U/ml each), 2 mM glutamine, 1% non-essential amino acids, 50 µM ?
IL-4 Binding (complemented) of in macrophages
1) Confidence 0.36 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.06 Pain Relevance 0
SM-MHCCre mice were backcrossed to Balb/c for nine generations and then intercrossed with IL-4R??
IL-4 Binding (intercrossed) of
2) Confidence 0.36 Published 2007 Journal PLoS Pathogens Section Body Doc Link PMC1769405 Disease Relevance 0.33 Pain Relevance 0.08
For our maternal transmission model, we conclude that the data do not support the postulate that IL-4 and 13 cross the placenta under these experimental conditions.
IL-4 Binding (cross) of in placenta
3) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.29 Pain Relevance 0.07
It is possible that even if transplacental passage of IL-4 or 13 occurred, phosphorylated STAT-6 may have already degraded by the time the embryos were harvested, leading to a false negative.
IL-4 Binding (passage) of in embryos
4) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0.16 Pain Relevance 0.04
fetuses injected with IL-4, respectively.
IL-4 Binding (injected) of
5) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0
From this data, it can be concluded that sufficient functional IL-4 did not cross the placenta.
IL-4 Neg (not) Binding (cross) of in placenta
6) Confidence 0.36 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2645503 Disease Relevance 0 Pain Relevance 0
can bind to the IL-4 promoter, and retroviral overexpression of C/EBP?
IL-4 Binding (bind) of
7) Confidence 0.32 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.10 Pain Relevance 0.10
The nuclear factor of activated T cells (NFAT) family of transcription factors has a critical role in T cell effector functions, and NFAT DNA-binding sites have been identified in many different cytokine genes, for example those of IL-2, IL-4, and IFN-?
IL-4 Binding (binding) of in NFAT associated with cytokine
8) Confidence 0.25 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0.14 Pain Relevance 0.21
is a proinflammatory cytokine that activates macrophages during inflammation, while IL-4 is associated with the resolution of inflammation.
IL-4 Binding (associated) of in macrophages associated with inflammation and cytokine
9) Confidence 0.18 Published 2010 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2840610 Disease Relevance 1.27 Pain Relevance 0.42
On the whole, it seems that the effect of Bv8 on the Th2 cytokines IL-4 and on IL-10 may not only be due to direct interactions with T lymphocytes, but may also be mediated by other cell types such as macrophages [19].
Th2 cytokines IL-4 Binding (interactions) of in T lymphocytes associated with cytokine
10) Confidence 0.17 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.13 Pain Relevance 0.15
, IL-4 and IL-5 in BAL fluid were determined using a Bioplex protein array system (Biorad) with matched antibody pairs for murine TNF-?
IL-4 Binding (fluid) of
11) Confidence 0.17 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.10 Pain Relevance 0.10
B- and T lymphocytes and macrophages were eliminated from bone marrow cells, which were cultured at 37°C for 7 days in 5% FCS-containing RPMI medium complemented with GM-CSF and IL-4 (200 U/ml each), 2 mM glutamine, 1% non-essential amino acids, 50 µM ?
IL-4 Binding (complemented) of in T lymphocytes
12) Confidence 0.12 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2883599 Disease Relevance 0.06 Pain Relevance 0
SOCS5 has been shown to inhibit IL-4 signaling by interacting with the IL-4 receptor and inhibiting JAK1 binding to the receptor [15].
IL-4 Binding (interacting) of
13) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174965 Disease Relevance 0 Pain Relevance 0.15
However, pre-treatment with IL-4 has in a Theiler's murine encephalomyelitis virus model showed inhibition of NF-?
IL-4 Binding (treatment) of associated with encephalitis
14) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.76 Pain Relevance 0.04
IL-4 is the ligand of two receptors: A high-affinity heterodimer of IL-4R?
IL-4 Binding (ligand) of
15) Confidence 0.09 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.20 Pain Relevance 0.18
It is known from the studies in different cell models that IL-4 is able to counteract many of the IL-1?
IL-4 Binding (counteract) of
16) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.71 Pain Relevance 0.45
The biological effects of IL-13 may be achieved through binding to the IL-4 receptor ?
IL-4 Binding (binding) of
17) Confidence 0.09 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2838227 Disease Relevance 0.58 Pain Relevance 0.48
Activation of melatonin receptors enhances the release of Th cell cytokines, such as gamma-interferon and interleukin-2, as well as novel opioid cytokines which cross-react immunologically with both interleukin-4 and dynorphin B.
interleukin-4 Binding (cross-react) of associated with dynorphin, opioid and cytokine
18) Confidence 0.08 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 9266542 Disease Relevance 0.34 Pain Relevance 0.36
These effects are mediated mainly by T-helper cell-derived opioid cytokines with an apparent molecular mass of 15 kDa and 67 kDa that are recognized both by anti-interleukin-4 and anti-dynorphin B antibodies.
anti-interleukin-4 Binding (recognized) of in T-helper cell associated with dynorphin, opioid and cytokine
19) Confidence 0.05 Published 1998 Journal Ann. N. Y. Acad. Sci. Section Abstract Doc Link 9629267 Disease Relevance 0.39 Pain Relevance 0.75
and IL-1 interact synergistically with IL-4 and IL-13 to augment VCAM-1 expression as well as intercellular adhesion molecule-1 (ICAM-1, CD54) expression.94 Recent data suggest that TNF-?
IL-4 Binding (interact) of associated with adhesions
20) Confidence 0.04 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2846745 Disease Relevance 0.96 Pain Relevance 0

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