INT70925

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Context Info
Confidence 0.14
First Reported 1996
Last Reported 2003
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ifng, Il4) extracellular region (Ifng, Il4)
Anatomy Link Frequency
T-lymphocytes 1
Ifng (Mus musculus)
Il4 (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 100.00 Very High Very High Very High
Opioid 2 100.00 Very High Very High Very High
Dynorphin 1 99.80 Very High Very High Very High
Inflammation 1 94.48 High High
Kappa opioid receptor 1 76.32 Quite High
peptic ulcer disease 1 53.60 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 94.48 High High
Bacterial Infection 1 90.64 High High
Cancer 2 86.48 High High
Hematological Disease 2 84.32 Quite High
Gastritis 3 75.00 Quite High
Stress 1 61.44 Quite High
Stomach Cancer 2 58.20 Quite High
Disease 2 53.60 Quite High
Ulcers 1 53.28 Quite High
Immunodeficiency 1 45.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes were associated with a shift of the T-lymphocytes response from a predominant T helper type 1 (Th1) response dominated by IFN-gamma to a Th1/Th2 response with IFN-gamma and IL-4.
IFN-gamma Binding (response) of IL-4 in T-lymphocytes
1) Confidence 0.14 Published 2003 Journal Int. Immunopharmacol. Section Abstract Doc Link 12810355 Disease Relevance 0.55 Pain Relevance 0.14
Activation of melatonin receptors enhances the release of Th cell cytokines, such as gamma-interferon and interleukin-2, as well as novel opioid cytokines which cross-react immunologically with both interleukin-4 and dynorphin B.
gamma-interferon Binding (cross-react) of interleukin-4 associated with dynorphin, opioid and cytokine
2) Confidence 0.02 Published 1996 Journal Neuroimmunomodulation Section Abstract Doc Link 9266542 Disease Relevance 0.34 Pain Relevance 0.37

General Comments

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