INT7093

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Context Info
Confidence 0.58
First Reported 1984
Last Reported 2010
Negated 2
Speculated 0
Reported most in Abstract
Documents 146
Total Number 146
Disease Relevance 37.30
Pain Relevance 48.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2B6) endoplasmic reticulum (CYP2B6)
Anatomy Link Frequency
liver 10
1A2 6
plasma 5
hepatocytes 2
blood 2
CYP2B6 (Homo sapiens)
Pain Link Frequency Relevance Heat
methadone 111 100.00 Very High Very High Very High
sSRI 83 99.98 Very High Very High Very High
Central nervous system 15 99.92 Very High Very High Very High
Potency 8 99.92 Very High Very High Very High
cINOD 28 99.88 Very High Very High Very High
fluoxetine 134 99.86 Very High Very High Very High
qutenza 36 99.82 Very High Very High Very High
anesthesia 28 99.80 Very High Very High Very High
antidepressant 46 99.60 Very High Very High Very High
Migraine 16 99.52 Very High Very High Very High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 7 99.98 Very High Very High Very High
Necrosis 20 99.88 Very High Very High Very High
Cirrhosis 13 99.78 Very High Very High Very High
INFLAMMATION 172 99.76 Very High Very High Very High
Headache 31 99.52 Very High Very High Very High
Infection 80 99.48 Very High Very High Very High
Death 47 99.44 Very High Very High Very High
Bacterial Respiratory Disease 6 99.40 Very High Very High Very High
Xerostomia 5 99.32 Very High Very High Very High
Nicotine Addiction 31 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P450 inhibition in this system appears to model that in vivo.
Negative_regulation (inhibition) of P450
1) Confidence 0.58 Published 2008 Journal Drug Metab. Dispos. Section Abstract Doc Link 18381489 Disease Relevance 0 Pain Relevance 0.07
We observed a 76% inhibition with SKF 525A, a P-450 inhibitor.
Negative_regulation (inhibitor) of P-450
2) Confidence 0.57 Published 1997 Journal Carcinogenesis Section Abstract Doc Link 9163687 Disease Relevance 0.25 Pain Relevance 0.44
Orphenadrine, a specific inhibitor to CYP2B6, and ketoconazole, a specific inhibitor to CYP3A4, inhibited the N-demethylation of ketamine in human liver microsomes.
Negative_regulation (inhibitor) of CYP2B6 in liver associated with ketamine
3) Confidence 0.57 Published 2002 Journal Drug Metab. Dispos. Section Abstract Doc Link 12065445 Disease Relevance 0 Pain Relevance 0.52
Selective inhibitors of P450s 1A, 2B6, 2C9/10, 2D6 and 3A4 did not affect halothane oxidation.
Negative_regulation (inhibitors) of P450 associated with halothane
4) Confidence 0.57 Published 1997 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9103523 Disease Relevance 0.22 Pain Relevance 0.41
BACKGROUND: Macrolide antibiotics such as clarithromycin are potent inhibitors of the cytochrome P450 (CYP)3A4 isozyme and have the potential to attenuate the metabolism and increase blood concentrations of drugs metabolized by this pathway.
Negative_regulation (inhibitors) of P450 in blood
5) Confidence 0.57 Published 2002 Journal Clin Ther Section Abstract Doc Link 12017403 Disease Relevance 0 Pain Relevance 0.20
In addition to EROD inhibition, Te-phenyl-L-tellurocysteine was the strongest inhibitor of several human cytochrome P450 isoenzymes followed by Se-phenyl-L-selenocysteine, while S-phenyl-L-cysteine was the weakest inhibitor.
Negative_regulation (inhibitor) of P450
6) Confidence 0.57 Published 2002 Journal Chem. Res. Toxicol. Section Abstract Doc Link 12482244 Disease Relevance 0 Pain Relevance 0.06
The authors hypothesized that fluoxetine, a known inhibitor of multiple P450 isoenzymes including 3A4, 2C9, and 2D6, would affect estrone metabolism, altering the 2-hydroxyestrone:16-alpha-hydroxyestrone (2OHE1:16OHE1) ratio.
Negative_regulation (inhibitor) of P450 associated with fluoxetine
7) Confidence 0.57 Published 2003 Journal Ther Drug Monit Section Abstract Doc Link 12548158 Disease Relevance 0 Pain Relevance 0.34
The selective serotonin reuptake inhibitor antidepressant fluoxetine inhibits alprazolam metabolism in vivo by inhibition of the cytochrome P450 3A4 enzyme.
Negative_regulation (inhibition) of P450 associated with antidepressant, ssri and fluoxetine
8) Confidence 0.57 Published 2003 Journal J Clin Psychopharmacol Section Abstract Doc Link 12920410 Disease Relevance 0 Pain Relevance 0.44
The antifungal properties of the azoles stem from their propensity to inhibit fungal cytochrome P-450 enzymes.
Negative_regulation (inhibit) of P-450 in stem associated with fungal infection
9) Confidence 0.57 Published 2003 Journal Drugs Today Section Abstract Doc Link 14668935 Disease Relevance 0.26 Pain Relevance 0.11
Finally, methadone appears to be a mixed-type inhibitor and not a suicide inhibitor of cytochrome P450 3A family.
Negative_regulation (inhibitor) of P450 associated with suicidal behaviour and methadone
10) Confidence 0.57 Published 1997 Journal Toxicology Section Abstract Doc Link 9020195 Disease Relevance 0.10 Pain Relevance 0.80
Methadone metabolism was 60-72% inhibited either by three mechanism-based inhibitors of P450 3A4 (gestodene, TAO, and erythralosamine) or by four reversible inhibitors of P450 3A (ketoconazole, dihydroergotamine, quercetin, and diazepam with an apparent Ki of 50 microM) and by two nonspecific inhibitors (metyrapone and SKF-525A).
Negative_regulation (inhibitors) of P450 associated with methadone
11) Confidence 0.57 Published 1996 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8839037 Disease Relevance 0 Pain Relevance 0.57
Methadone metabolism was 60-72% inhibited either by three mechanism-based inhibitors of P450 3A4 (gestodene, TAO, and erythralosamine) or by four reversible inhibitors of P450 3A (ketoconazole, dihydroergotamine, quercetin, and diazepam with an apparent Ki of 50 microM) and by two nonspecific inhibitors (metyrapone and SKF-525A).
Negative_regulation (inhibitors) of P450 associated with methadone
12) Confidence 0.57 Published 1996 Journal Chem. Res. Toxicol. Section Abstract Doc Link 8839037 Disease Relevance 0 Pain Relevance 0.52
Among other compounds discussed here are dexamethasone, nonsteroidal anti-inflammatory drugs, and inhibitors of cytochrome P450 enzymes, for example, ketoconazole.
Negative_regulation (inhibitors) of P450 associated with inflammation, cinod and dexamethasone
13) Confidence 0.57 Published 2004 Journal Exp. Cell Res. Section Abstract Doc Link 15265684 Disease Relevance 0.31 Pain Relevance 0.15
As fluoxetine is a potent inhibitor of cytochrome P450 (CYP) 2D6, these results also provide indirect evidence for an involvement of CYP2D6 in the metabolism of haloperidol.
Negative_regulation (inhibitor) of P450 associated with fluoxetine
14) Confidence 0.57 Published 1997 Journal Pharmacol. Res. Section Abstract Doc Link 9264051 Disease Relevance 0.06 Pain Relevance 0.47
Many of these drugs are potent inhibitors of the cytochrome P-450 enzymes (CYPs) of the liver.
Negative_regulation (inhibitors) of P-450 in liver
15) Confidence 0.57 Published 1997 Journal Mayo Clin. Proc. Section Abstract Doc Link 9294531 Disease Relevance 0.09 Pain Relevance 0.51
Nefazodone is a weak inhibitor of cytochrome P450 (CYP) 2D6 and does not inhibit CYP1A2.
Negative_regulation (inhibitor) of P450
16) Confidence 0.57 Published 1997 Journal Clin Pharmacokinet Section Abstract Doc Link 9342502 Disease Relevance 0 Pain Relevance 0.10
Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency.
Negative_regulation (deficiency) of P-450 associated with death and fluoxetine
17) Confidence 0.57 Published 2000 Journal J Child Adolesc Psychopharmacol Section Title Doc Link 10755579 Disease Relevance 1.08 Pain Relevance 0.53
Relative to other SSRIs, fluvoxamine is a weak inhibitor of cytochrome P450 (CYP) 2D6, a moderate inhibitor of CYP2C19 and CYP3A4 and a potent inhibitor of CYP1A2.
Negative_regulation (inhibitor) of P450 associated with ssri
18) Confidence 0.57 Published 2000 Journal Drugs Section Abstract Doc Link 11085201 Disease Relevance 0.31 Pain Relevance 0.25
Inhibitors of cytochrome P-450 isoenzymes 3A4 and 2C19 should be used cautiously in patients taking cilostazol, and this drug is contraindicated in patients with congestive heart failure.
Negative_regulation (Inhibitors) of P-450 in heart associated with heart rate under development
19) Confidence 0.57 Published 2001 Journal Am J Health Syst Pharm Section Abstract Doc Link 11286146 Disease Relevance 1.50 Pain Relevance 0.74
On the other hand, inhibition of CYPs involved in carcinogen activation and scavenging reactive species formed from carcinogens by CYP-mediated reactions can be beneficial properties of various flavonoids.
Negative_regulation (inhibition) of CYPs
20) Confidence 0.57 Published 2002 Journal Chem. Biol. Interact. Section Abstract Doc Link 11803026 Disease Relevance 0.36 Pain Relevance 0.10

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