INT70946

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Context Info
Confidence 0.34
First Reported 1996
Last Reported 1996
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 2.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Penk, Hpse) hydrolase activity, acting on glycosyl bonds (Hpse) cell adhesion (Hpse)
nucleus (Hpse) carbohydrate metabolic process (Hpse) lysosome (Hpse)
Penk (Rattus norvegicus)
Hpse (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 30 100.00 Very High Very High Very High
Opioid 4 98.76 Very High Very High Very High
antagonist 8 94.72 High High
narcan 6 88.48 High High
opioid receptor 2 87.44 High High
Intracerebroventricular 2 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These enkephalins, given intracerebroventricularly (i.c.v.) increased dose-dependently the activity of the HPA axis, measured indirectly through serum corticosterone levels.
enkephalin Positive_regulation (increased) of HPA associated with enkephalin
1) Confidence 0.34 Published 1996 Journal Folia Med Cracov Section Abstract Doc Link 9269123 Disease Relevance 0 Pain Relevance 1.13
These results indicate that both met- and leu-enkephalin increase the activity of the HPA axis in rats and both central opioid and adrenergic alpha-receptors are involved in this stimulation.
leu-enkephalin Positive_regulation (increase) of HPA associated with enkephalin and opioid
2) Confidence 0.29 Published 1996 Journal Folia Med Cracov Section Abstract Doc Link 9269123 Disease Relevance 0 Pain Relevance 1.52

General Comments

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