INT70954

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Context Info
Confidence 0.41
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 4.22
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Cd3e) signal transducer activity (Cd3e)
Anatomy Link Frequency
T cells 2
blood 1
lymphocytes 1
B cells 1
bone marrow 1
Cd3e (Mus musculus)
Pain Link Frequency Relevance Heat
Substantia nigra 49 97.04 Very High Very High Very High
cytokine 211 95.68 Very High Very High Very High
cINOD 4 90.64 High High
antagonist 52 90.48 High High
opioid receptor 4 90.04 High High
Cannabinoid 1 87.28 High High
Opioid 4 81.88 Quite High
Inflammation 160 81.28 Quite High
agonist 43 50.00 Quite Low
Potency 3 39.60 Quite Low
Disease Link Frequency Relevance Heat
Renal Failure 1 99.98 Very High Very High Very High
Sensorineural Hearing Loss 2 99.52 Very High Very High Very High
Stress 10 99.36 Very High Very High Very High
Occupational Lung Diseases 17 98.64 Very High Very High Very High
Infection 16 98.52 Very High Very High Very High
Epstein-barr Virus 31 98.48 Very High Very High Very High
Asthma 357 96.12 Very High Very High Very High
Death 64 94.96 High High
Deafness 2 94.64 High High
T-cell Lymphoma 21 93.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reversible sensorineural hearing loss after renal transplant immunosuppression with OKT3 (muromonab-CD3).
Negative_regulation (immunosuppression) of CD3 associated with renal failure and sensorineural hearing loss
1) Confidence 0.41 Published 1997 Journal Ann. Otol. Rhinol. Laryngol. Section Title Doc Link 9270425 Disease Relevance 0.47 Pain Relevance 0.09
RST of infected mice significantly suppressed splenic CD3(-)DX5+ cellularity and NK cytolytic activity.
Negative_regulation (suppressed) of CD3 associated with stress
2) Confidence 0.30 Published 2005 Journal Brain Behav. Immun. Section Abstract Doc Link 15664788 Disease Relevance 1.12 Pain Relevance 0.51
In contrast, exposure during late gestation was associated with decreases in CD3+ and CD4+ fractions and increases in CD19+ and NK cell fractions.
Negative_regulation (decreases) of CD3 in NK cell
3) Confidence 0.26 Published 2010 Journal Environ Health Section Body Doc Link PMC2927516 Disease Relevance 0.16 Pain Relevance 0
T cells were accompanied by concurrent decreases in absolute number of CD3+/CD69+, IgE+/B220+ B cells (Table 2, Figure 6).
Negative_regulation (decreases) of CD3 in B cells
4) Confidence 0.22 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2276601 Disease Relevance 0.28 Pain Relevance 0.05
This might lead to a shift in CD3+ and non CD3+ lymphocytes after allogeneic bone marrow transplantation compared to syngeneic bone marrow transplantation.
Negative_regulation (shift) of CD3 in bone marrow
5) Confidence 0.21 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2701999 Disease Relevance 0.40 Pain Relevance 0
However, our preliminary cytofluorimetric analysis seems to indicate that IL-10 production is decreased mainly in CD3+ lymphocytes [Franchi et al., unpublished results].
Negative_regulation (decreased) of CD3 in lymphocytes
6) Confidence 0.19 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2584092 Disease Relevance 0.14 Pain Relevance 0.13
In stable asthmatics systemic glucocorticoid treatment produces a small but significant decrease of 16% in blood CD3+CD4+ and a 12% increase in natural killer(NK)-cell frequency within 3 hours.
Negative_regulation (decrease) of CD3 in blood associated with occupational lung diseases
7) Confidence 0.08 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.35 Pain Relevance 0.10
One of these cases was negative for cytotoxic markers and was positive only for CD2 and CD3.
Negative_regulation (positive) of CD3
8) Confidence 0.06 Published 2008 Journal J Hematop Section Body Doc Link PMC2713479 Disease Relevance 1.00 Pain Relevance 0.03
Interestingly, the presence of CD3+ cells was consistently seen in all animals in the ?
Negative_regulation (presence) of CD3
9) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808388 Disease Relevance 0.16 Pain Relevance 0.25
Using the Pan T cell Isolation Kit (Miltenyi Biotec, Germany), highly purified human CD3+-T cells were isolated by depletion of CD3?
Negative_regulation (depletion) of CD3 in T cells
10) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809084 Disease Relevance 0.14 Pain Relevance 0.11
In order to explore indirect influence of MP on IL-17 production, which could be important for the observed difference in efficiency of MP in inhibition of IL-17 in purified T cells and LNC, CD3- cells were stimulated with LPS in the presence or absence of MP and production of a major IL-17-promoting cytokine – IL-6 was determined.
Negative_regulation (inhibition) of CD3 in T cells associated with cytokine
11) Confidence 0.01 Published 2008 Journal BMC Immunol Section Body Doc Link PMC2525626 Disease Relevance 0 Pain Relevance 0.05

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