INT70971

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Context Info
Confidence 0.40
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.65
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SERPINE1) extracellular region (SERPINE1) plasma membrane (SERPINE1)
Anatomy Link Frequency
Adipose tissue 2
fibroblasts 2
SERPINE1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 3 99.38 Very High Very High Very High
Inflammation 61 97.80 Very High Very High Very High
cytokine 15 88.48 High High
Osteoarthritis 1 86.68 High High
Inflammatory marker 3 86.60 High High
alcohol 3 50.80 Quite High
Inflammatory mediators 2 35.12 Quite Low
Angina 7 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
aspirin 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Obesity 13 99.34 Very High Very High Very High
Hypertension 42 98.60 Very High Very High Very High
INFLAMMATION 79 97.80 Very High Very High Very High
Atherosclerosis 44 94.32 High High
Insulin Resistance 2 90.60 High High
Weight Loss 1 89.60 High High
Body Weight 1 88.56 High High
Acute Coronary Syndrome 6 81.32 Quite High
Targeted Disruption 1 78.72 Quite High
Metabolic Syndrome 4 75.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts.
Negative_regulation (reduce) of Positive_regulation (increasing) of PAI-1 in fibroblasts associated with cinod
1) Confidence 0.40 Published 1997 Journal Clin. Exp. Rheumatol. Section Title Doc Link 9272300 Disease Relevance 0.09 Pain Relevance 0.33
Hypertension is often associated with impaired fibrinolysis, usually expressed by increased levels of plasminogen activator inhibitor type 1 (PAI-1) and decreased activity of tissue plasminogen activator (t-PA).31 Combination therapy with amlodipine and atorvastatin improved the fibrinolytic balance more than either single agent in hypertensive hypercholesterolemic patients with insulin resistance.31
Negative_regulation (inhibitor) of Positive_regulation (increased) of PAI-1 associated with hypertension and insulin resistance
2) Confidence 0.11 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2686256 Disease Relevance 1.01 Pain Relevance 0.04
Adipose tissue present in excess also releases increased amounts of plasminogen activator inhibitor-1 (PAI-1), which imbalances the fibrinolytic system towards prothrombosis [98,99].
Negative_regulation (amounts) of Positive_regulation (increased) of PAI-1 in Adipose tissue associated with obesity
3) Confidence 0.10 Published 2003 Journal Thromb J Section Body Doc Link PMC179880 Disease Relevance 1.54 Pain Relevance 0.20

General Comments

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