INT70987

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Context Info
Confidence 0.37
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 19
Disease Relevance 12.14
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (RAC1) cell motility (RAC1) cell adhesion (RAC1)
plasma membrane (RAC1) enzyme binding (RAC1) GTPase activity (RAC1)
Anatomy Link Frequency
eye 1
levator palpebrae superioris 1
autonomic 1
RAC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Botox 339 100.00 Very High Very High Very High
anesthesia 17 99.92 Very High Very High Very High
Snapping jaw 5 99.72 Very High Very High Very High
headache 1 98.84 Very High Very High Very High
Migraine 5 98.24 Very High Very High Very High
cytokine 108 96.32 Very High Very High Very High
Multiple sclerosis 2 93.24 High High
Pain 45 92.28 High High
Inflammation 150 91.96 High High
ischemia 11 81.12 Quite High
Disease Link Frequency Relevance Heat
Dislocations 6 99.96 Very High Very High Very High
Autonomic Nervous System Disease 1 99.96 Very High Very High Very High
Temporomandibular Joint Syndrome 5 99.72 Very High Very High Very High
Adhesions 72 99.68 Very High Very High Very High
Atherosclerosis 71 99.68 Very High Very High Very High
Voice Disorders 7 99.48 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 67 99.44 Very High Very High Very High
Diplopia 32 99.16 Very High Very High Very High
Coagulation Disorder 9 99.12 Very High Very High Very High
Tremor 1 99.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, botulinum toxin has been shown to impact autonomic disorders by acting at acceptors on glands and smooth muscle, and consequently it has been used in the management of a number of other conditions including hypersecretory disorders, pain syndromes, detrusor sphinchter dyssenergia or overactivity and gastointestinal smooth muscle/sphincter spasm; it may also reduce pain in patients for whom it is used to treat these and other primary conditions.
botulinum toxin Binding (impact) of in autonomic associated with pain, autonomic nervous system disease, syndrome, muscular spasm and overactive bladder
1) Confidence 0.37 Published 2009 Journal Curr. Pharm. Des. Section Abstract Doc Link 19925419 Disease Relevance 1.33 Pain Relevance 0.18
B, a regulator of several genes implicated in atherogenesis, such as genes coding for intracellular adhesion molecule-1 (ICAM-1) and vascular cellular adhesion molecule-1 (VCAM-1) and cytokines. ?
rac Binding (coding) of associated with atherosclerosis, adhesions and cytokine
2) Confidence 0.36 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2747395 Disease Relevance 1.64 Pain Relevance 0.29
One recovered following an injection of botulinum toxin to the medial rectus of her affected eye 11 months after the onset of diplopia.
botulinum toxin Binding (injection) of in eye associated with diplopia
3) Confidence 0.30 Published 2007 Journal Cephalalgia Section Abstract Doc Link 17381560 Disease Relevance 1.13 Pain Relevance 0.50
Definition and therapy with botulinum toxin].
botulinum toxin Binding (Definition) of
4) Confidence 0.28 Published 1997 Journal Nervenarzt Section Title Doc Link 9273466 Disease Relevance 1.15 Pain Relevance 0.46
We have established Raichu-FLIM [37], whereby upon GTP binding, Rac1/Cdc42/RhoA exhibits a higher affinity towards the corresponding RhoGTPase-interacting domain, bringing the two different fluorescent proteins of the biosensor into close proximity and enabling FRET between GFP and mRFP1.
Rac1 Binding (binding) of
5) Confidence 0.27 Published 2009 Journal Target Oncol Section Body Doc Link PMC2778706 Disease Relevance 0.13 Pain Relevance 0.06
Botulinum toxin type A in an appropriate vehicle and applied directly to the axillae may prove to be an effective treatment.27
Botulinum toxin Binding (applied) of associated with botox
6) Confidence 0.23 Published 2008 Journal Eplasty Section Body Doc Link PMC2344132 Disease Relevance 0.51 Pain Relevance 0.15
Contraindications to botulinum toxin type A which include bleeding disorders, myasthenia gravis and concurrent use of aminoglycosides.

?

botulinum toxin Binding (Contraindications) of associated with coagulation disorder, myasthenia gravis and botox
7) Confidence 0.21 Published 2008 Journal Trials Section Body Doc Link PMC2611962 Disease Relevance 1.43 Pain Relevance 0.18
Nonetheless, given its long safety track record and high usage in millions of patients, knowledge of any potential adverse effects associated with botulinum toxin is essential for any practitioner who performs such injections.
botulinum toxin Binding (associated) of
8) Confidence 0.19 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.17 Pain Relevance 0.03
This suggested that PGE2 secretion plays an important role in Rac1 stimulation, which was further supported by the 2.4-fold activity of Rac1 in the lysates prepared from cells plated in the presence of PGE2 alone for 30?
Rac1 Binding (activity) of
9) Confidence 0.19 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0 Pain Relevance 0
Patient reported outcomes with botulinum toxin
botulinum toxin Binding (outcomes) of
10) Confidence 0.15 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.62 Pain Relevance 0.05
Transient ptosis is the most frequently reported complication and has been reported in the literature in approximately 5% of patients.40,44 Ptosis of the eyelid results from migration of the botulinum toxin to the levator palpebrae superioris muscle.
botulinum toxin Binding (migration) of in levator palpebrae superioris associated with ocular toxicity (including many sub-types)
11) Confidence 0.15 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.75 Pain Relevance 0
However, the most common nonsurgical cosmetic procedure performed in the treatment of rhytides is injection with botulinum toxin.
botulinum toxin Binding (injection) of
12) Confidence 0.15 Published 2010 Journal Patient Prefer Adherence Section Abstract Doc Link PMC2943226 Disease Relevance 0.17 Pain Relevance 0
Concomitant administration of botulinum toxin and aminoglycosides or other agents interfering with neuromuscular transmission (eg, curare-like nondepolarizing blockers, lincosamides, polymyxins, quinidine, magnesium sulfate, anticholinesterases, succinylcholine chloride) should be performed with caution as the effect of the toxin may be potentiated, resulting in excessive neuromuscular weakness.43

Pregnancy and lactation

botulinum toxin Binding (administration) of
13) Confidence 0.15 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.97 Pain Relevance 0
After meeting various exclusion and inclusion criteria, these patients were selected to receive botulinum toxin type A (BoNT/A) treatment, followed by a 6 week physical therapy regimen.
botulinum toxin Binding (type) of associated with botox
14) Confidence 0.15 Published 2009 Journal J Orthop Surg Res Section Body Doc Link PMC2743655 Disease Relevance 0.45 Pain Relevance 0.13
Caution should be exercised when botulinum toxin is administered to a nursing woman because it is not known whether this drug is excreted in human milk.43

Ptosis and asymmetry

botulinum toxin Binding (administered) of associated with ocular toxicity (including many sub-types)
15) Confidence 0.13 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2943226 Disease Relevance 0.89 Pain Relevance 0
The Rho branch constitutes a second major branch, with RhoA, Rac1 and Cdc42 the most studied members.
Rac1 Binding (branch) of
16) Confidence 0.13 Published 2007 Journal Immun Ageing Section Body Doc Link PMC1845171 Disease Relevance 0.17 Pain Relevance 0.06
link between apocynin and Rac1 inhibition suggests that apocynin may be a
Rac1 Binding (link) of
17) Confidence 0.11 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2593395 Disease Relevance 0.63 Pain Relevance 0.04
Rac1 directly binds and phosphorylates the transcription factor STAT3 [32].
Rac1 Binding (binds) of
18) Confidence 0.05 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0 Pain Relevance 0
DOCK180 binds and activates Rac1 [31].
Rac1 Binding (binds) of
19) Confidence 0.05 Published 2008 Journal BMC Syst Biol Section Body Doc Link PMC2254585 Disease Relevance 0 Pain Relevance 0

General Comments

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