INT70994

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Context Info
Confidence 0.51
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 3.49
Pain Relevance 3.12

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
monocyte 3
joints 2
endothelial cell 2
endothelium 2
macrophage 1
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 16 100.00 Very High Very High Very High
dexamethasone 21 99.98 Very High Very High Very High
nMDA receptor 8 99.80 Very High Very High Very High
Inflammation 57 98.64 Very High Very High Very High
cINOD 5 96.32 Very High Very High Very High
Angina 2 90.60 High High
substance P 16 85.36 High High
ischemia 2 81.60 Quite High
c fibre 2 68.56 Quite High
nMDA receptor antagonist 2 66.96 Quite High
Disease Link Frequency Relevance Heat
Adhesions 20 100.00 Very High Very High Very High
INFLAMMATION 62 98.64 Very High Very High Very High
Death 2 93.72 High High
Necrosis 4 93.08 High High
Cancer 4 92.72 High High
Arrhythmias 2 Under Development 1 91.56 High High
Cv General 3 Under Development 2 90.60 High High
Myocardial Infarction 1 89.56 High High
Stroke 1 88.64 High High
Reperfusion Injury 2 80.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Incubation of EA.hy926 cells with 1 microM dexamethasone prior to addition of TNF-alpha consistently reduced ICAM-1 induction by approximately 40%.
Negative_regulation (reduced) of Positive_regulation (induction) of ICAM-1 associated with dexamethasone
1) Confidence 0.51 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.44 Pain Relevance 0.37
Inhibition of ICAM-1 up-regulation may, at least in part, mediate the potent anti-migratory action displayed by this class of anti-inflammatory drugs.
Negative_regulation (Inhibition) of Positive_regulation (up-regulation) of ICAM-1 associated with inflammation and cinod
2) Confidence 0.51 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.43 Pain Relevance 0.53
Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines.
Negative_regulation (inhibits) of Positive_regulation (up-regulation) of intercellular adhesion molecule-1 in endothelial cell associated with dexamethasone, adhesions and cytokine
3) Confidence 0.44 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9274931 Disease Relevance 0.48 Pain Relevance 0.42
The ability of the kappa-agonist, PD117302, to inhibit both the inflammation and upregulation of ICAM-1 in arthritic joints emphasizes the potential of kappa-agonists as antiarthritic agents.


Negative_regulation (inhibit) of Positive_regulation (upregulation) of ICAM-1 in joints
4) Confidence 0.43 Published 1998 Journal J. Rheumatol. Section Body Doc Link 9517771 Disease Relevance 0 Pain Relevance 0
Immunohistochemical and Western blot analyses of ventricular tissue demonstrated that NMDA receptor blockade abolished MgD-related increase of endothelium adhesion molecule CD54 (weeks 1 and 2; p < 0.05), and of monocyte/macrophage surface protein CD11b expression (week 3; p < 0.05).
Negative_regulation (abolished) of Positive_regulation (increase) of CD54 in monocyte associated with nmda receptor and adhesions
5) Confidence 0.30 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15169828 Disease Relevance 0.23 Pain Relevance 0.65
In contrast, a positive staining for ICAM-1 and P-selectin was significantly attenuated by the treatment with Hypericum (Figure 5d and 5f respectively).
Negative_regulation (attenuated) of Positive_regulation (staining) of ICAM-1
6) Confidence 0.23 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3000377 Disease Relevance 0.38 Pain Relevance 0.17
Immunohistochemical and Western blot analyses of ventricular tissue demonstrated that NMDA receptor blockade abolished MgD-related increase of endothelium adhesion molecule CD54 (weeks 1 and 2; p < 0.05), and of monocyte/macrophage surface protein CD11b expression (week 3; p < 0.05).
Negative_regulation (abolished) of in macrophage Positive_regulation (increase) of CD54 in monocyte associated with nmda receptor and adhesions
7) Confidence 0.10 Published 2004 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15169828 Disease Relevance 0.23 Pain Relevance 0.65
The amount of endothelium-derived soluble forms of vascular-1 and intercellular-1 adhesion molecules increases after cardiopulmonary bypass suggesting endothelial dysfunction.
Negative_regulation (derived) of Positive_regulation (increases) of intercellular-1 in endothelium associated with adhesions
8) Confidence 0.07 Published 2009 Journal Medicina (Kaunas) Section Abstract Doc Link 19605962 Disease Relevance 1.32 Pain Relevance 0.33

General Comments

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