INT70996

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Context Info
Confidence 0.60
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 6.02
Pain Relevance 3.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Icam1) cell adhesion (Icam1) plasma membrane (Icam1)
Anatomy Link Frequency
plasma 2
endothelial cell 2
brain 2
duodenum 2
midbrain 2
Icam1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 13 100.00 Very High Very High Very High
rheumatoid arthritis 89 99.98 Very High Very High Very High
IPN 8 99.98 Very High Very High Very High
dexamethasone 16 99.80 Very High Very High Very High
Angina 22 99.12 Very High Very High Very High
midbrain 1 99.08 Very High Very High Very High
Inflammation 40 96.64 Very High Very High Very High
Thalamus 1 93.60 High High
Inflammatory response 1 87.92 High High
Central nervous system 31 76.60 Quite High
Disease Link Frequency Relevance Heat
Adhesions 25 100.00 Very High Very High Very High
Rheumatoid Arthritis 101 99.98 Very High Very High Very High
Inflammatory Pain 8 99.98 Very High Very High Very High
Stable Angina Pectoris 10 99.12 Very High Very High Very High
Cv General 3 Under Development 13 98.54 Very High Very High Very High
Myocardial Infarction 8 97.98 Very High Very High Very High
INFLAMMATION 47 96.64 Very High Very High Very High
Edema 4 94.00 High High
Cancer 7 91.96 High High
Necrosis 21 91.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Finally, the effect of the steroid on cytokine-induced ICAM-1 up-regulation was functionally related to its ability to suppress in vitro neutrophil trans-endothelial passage.
Positive_regulation (induced) of Positive_regulation (up-regulation) of ICAM-1 in neutrophil associated with cytokine
1) Confidence 0.60 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274931 Disease Relevance 0.40 Pain Relevance 0.54
The findings of the present study were that CIP induces increased ICAM-1 mRNA and protein expression at the BBB and that systemic proinflammatory mediators play no apparent role in the early response (1-6 h); however, brain region-specific increases in microglial activation suggest a potential for a central-mediated response.
Positive_regulation (induces) of Positive_regulation (increased) of ICAM-1 mRNA in brain associated with ipn
2) Confidence 0.50 Published 2006 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 16199477 Disease Relevance 0.70 Pain Relevance 0.80
Flurbiprofen caused a slight upregulation of ICAM-1 in the gastric mucosa and duodenum, whereas NO-flurbiprofen had no affect on expression.
Positive_regulation (caused) of Positive_regulation (upregulation) of ICAM-1 in duodenum
3) Confidence 0.46 Published 2005 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 16020654 Disease Relevance 0.35 Pain Relevance 0.07
Dexamethasone inhibits cytokine-induced intercellular adhesion molecule-1 up-regulation on endothelial cell lines.
Positive_regulation (up-regulation) of Positive_regulation (cytokine-induced) of intercellular adhesion molecule-1 in endothelial cell associated with dexamethasone, adhesions and cytokine
4) Confidence 0.38 Published 1997 Journal Eur. J. Pharmacol. Section Title Doc Link 9274931 Disease Relevance 0.48 Pain Relevance 0.42
Increased levels of ICAM-1 mRNA were detectable after midbrain irradiation with 2 Gy [16].
Positive_regulation (levels) of Positive_regulation (Increased) of ICAM-1 mRNA in midbrain associated with midbrain
5) Confidence 0.23 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.87 Pain Relevance 0.34
The frequency and persistent time of angina pectois, dosage of nitroglycerin used, changes of electrocardiogram (ECG) were observed, and the plasma levels of endothelin (ET), nitric oxide (NO), von Willebrand factor (vWF), soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were tested before and after the two-month therapeutic course.
Positive_regulation (tested) of Positive_regulation (levels) of intercellular adhesion molecule-1 in plasma
6) Confidence 0.19 Published 2009 Journal Zhongguo Zhong Xi Yi Jie He Za Zhi Section Body Doc Link 19338157 Disease Relevance 0.16 Pain Relevance 0
Serum levels ICAM-1 were similar among patients with AMI (424.1 +/- 15.2 ng/ml), UAP (403 +/- 12.3 ng/ml) and SAP (381.2 +/- 16.2 ng/ml); however, levels of ICAM-1 was significantly elevated in these groups as compared to the controls (244.3 +/- 11).
Positive_regulation (elevated) of Positive_regulation (elevated) of ICAM-1 associated with angina and myocardial infarction
7) Confidence 0.17 Published 2004 Journal Int. J. Cardiol. Section Abstract Doc Link 15262039 Disease Relevance 2.37 Pain Relevance 1.36
Compared with controls, patients with RA had significantly higher levels of, sICAM-1, MCP-1 and VWF, with a tendency also for sVCAM-1 to be higher (P = 0.059; Table 3).
Positive_regulation (had) of Positive_regulation (levels) of sICAM-1 associated with rheumatoid arthritis
8) Confidence 0.03 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945061 Disease Relevance 0.69 Pain Relevance 0.23

General Comments

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