INT70999

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 2.73
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Odc1) lyase activity (Odc1)
Anatomy Link Frequency
margin 4
liver 3
macrophages 2
brain 1
Odc1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 20 97.62 Very High Very High Very High
Intracerebroventricular 2 96.66 Very High Very High Very High
opiate 8 88.52 High High
peptic ulcer disease 3 76.72 Quite High
Inflammatory response 1 55.24 Quite High
narcan 2 32.00 Quite Low
opioid receptor 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Lymphatic System Cancer 2 100.00 Very High Very High Very High
Ulcers 13 99.68 Very High Very High Very High
Apoptosis 4 98.34 Very High Very High Very High
Peptic Ulcer 10 95.84 Very High Very High Very High
Sprains And Strains 2 78.20 Quite High
Disease 3 74.52 Quite High
Gastrointestinal Disease 2 71.88 Quite High
INFLAMMATION 1 54.88 Quite High
Infection 1 51.72 Quite High
Stomach Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin.
Positive_regulation (up-regulation) of Gene_expression (expression) of ODC in margin associated with lymphatic system cancer, ulcers and apoptosis
1) Confidence 0.43 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.25 Pain Relevance 0.07
Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin.
Positive_regulation (up-regulation) of Gene_expression (expression) of ornithine decarboxylase in margin associated with lymphatic system cancer, ulcers and apoptosis
2) Confidence 0.31 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.25 Pain Relevance 0.07
Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.
Positive_regulation (increases) of Gene_expression (produced) of ornithine decarboxylase in liver associated with intracerebroventricular and morphine
3) Confidence 0.29 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.53
Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.
Positive_regulation (increases) of in brain Gene_expression (produced) of ornithine decarboxylase in liver associated with intracerebroventricular and morphine
4) Confidence 0.10 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.53
When macrophages were cocultured with H. pylori, killing of bacteria was enhanced by transfection of ODC siRNA and prevented by addition of spermine.
Positive_regulation (transfection) of Gene_expression (transfection) of ODC in macrophages
5) Confidence 0.09 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.23 Pain Relevance 0.10

General Comments

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