INT70999

Context Info Confidence 0.43 First Reported 1997 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 5 Disease Relevance 2.73 Pain Relevance 1.30

cytosol (Odc1) lyase activity (Odc1)

Anatomy Link Frequency margin 4 liver 3 macrophages 2 brain 1 Odc1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Morphine 20 97.62 Intracerebroventricular 2 96.66 opiate 8 88.52 peptic ulcer disease 3 76.72 Inflammatory response 1 55.24 narcan 2 32.00 opioid receptor 2 25.00

Disease Link Frequency Relevance Heat Lymphatic System Cancer 2 100.00 Ulcers 13 99.68 Apoptosis 4 98.34 Peptic Ulcer 10 95.84 Sprains And Strains 2 78.20 Disease 3 74.52 Gastrointestinal Disease 2 71.88 INFLAMMATION 1 54.88 Infection 1 51.72 Stomach Cancer 1 5.00

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin.

Positive_regulation (up-regulation) of Gene_expression (expression) of ODC in margin associated with lymphatic system cancer, ulcers and apoptosis

1) Confidence 0.43 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.25 Pain Relevance 0.07

Cell apoptosis to cell proliferation ratio was strongly decreased and accompanied by significant up-regulation of ornithine decarboxylase (ODC) and B-cell lymphoma 2 (Bcl-2) protein expression at the ulcer margin.

Positive_regulation (up-regulation) of Gene_expression (expression) of ornithine decarboxylase in margin associated with lymphatic system cancer, ulcers and apoptosis

2) Confidence 0.31 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.25 Pain Relevance 0.07

Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.

Positive_regulation (increases) of Gene_expression (produced) of ornithine decarboxylase in liver associated with intracerebroventricular and morphine

3) Confidence 0.29 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.53

Intracerebroventricular (i.c.v.) injection of a single dose of morphine (2 microg) to 6-day-old rats markedly decreased basal brain and liver ornithine decarboxylase activity as well as the increases in hepatic ornithine decarboxylase activity produced by subcutaneously (s.c.) administered insulin, an important trophic hormone.

Positive_regulation (increases) of in brain Gene_expression (produced) of ornithine decarboxylase in liver associated with intracerebroventricular and morphine

4) Confidence 0.10 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9274973 Disease Relevance 0 Pain Relevance 0.53

When macrophages were cocultured with H. pylori, killing of bacteria was enhanced by transfection of ODC siRNA and prevented by addition of spermine.

Positive_regulation (transfection) of Gene_expression (transfection) of ODC in macrophages

5) Confidence 0.09 Published 2005 Journal J. Biol. Chem. Section Abstract Doc Link 15548540 Disease Relevance 0.23 Pain Relevance 0.10

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