INT71030

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Context Info
Confidence 0.48
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 39
Total Number 40
Disease Relevance 10.27
Pain Relevance 12.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mc1r) signal transduction (Mc1r) plasma membrane (Mc1r)
signal transducer activity (Mc1r)
Anatomy Link Frequency
melanocyte 6
pigmentation 4
papilla 2
hair 2
skin 2
Mc1r (Mus musculus)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 894 100.00 Very High Very High Very High
antagonist 42 100.00 Very High Very High Very High
TRP channel 4 99.80 Very High Very High Very High
agonist 49 99.76 Very High Very High Very High
sodium channel 1 99.40 Very High Very High Very High
Inflammation 64 98.04 Very High Very High Very High
qutenza 24 97.04 Very High Very High Very High
imagery 8 96.68 Very High Very High Very High
Lamotrigine 1 96.68 Very High Very High Very High
Neuropeptide 16 93.80 High High
Disease Link Frequency Relevance Heat
Skin Cancer 393 100.00 Very High Very High Very High
Freckles 164 99.76 Very High Very High Very High
INFLAMMATION 69 99.34 Very High Very High Very High
Infection 3 99.00 Very High Very High Very High
Alopecia 3 98.36 Very High Very High Very High
Apoptosis 38 95.32 Very High Very High Very High
Hypersensitivity 79 94.36 High High
Depression 3 92.44 High High
Diabetes Mellitus 34 92.28 High High
Anxiety Disorder 5 91.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Agouti, the ligand of Mc1r, is an inverse agonist that, when bound, reduces Mc1r activity (via lowered cAMP signaling) resulting in lighter pigmentation.
Mc1r Binding (bound) of in pigmentation associated with melanocortin 1 receptor and agonist
1) Confidence 0.48 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.84
Because the Mc1r and Agouti proteins interact physically, we tested for epistasis by performing gene interaction analyses (MapManager QTXb [20]).
Mc1r Binding (interact) of associated with melanocortin 1 receptor
2) Confidence 0.48 Published 2007 Journal PLoS Biol Section Body Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.28
Such pigment switching is controlled by the interaction of two genes: the melanocortin-1 receptor (Mc1r), which encodes a seven-transmembrane receptor expressed in melanocytes, and its ligand, agouti, whose protein product is secreted from nearby dermal papilla cells and acts to inhibit Mc1r signaling.
Mc1r Binding (interaction) of in papilla associated with melanocortin 1 receptor
3) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.48
Such pigment switching is controlled by the interaction of two genes: the melanocortin-1 receptor (Mc1r), which encodes a seven-transmembrane receptor expressed in melanocytes, and its ligand, agouti, whose protein product is secreted from nearby dermal papilla cells and acts to inhibit Mc1r signaling.
melanocortin-1 receptor Binding (interaction) of in papilla associated with melanocortin 1 receptor
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2806840 Disease Relevance 0 Pain Relevance 0.48
Thus, it is unclear why Mc1r has repeatedly been shown to be associated with melanism in nature and a key question is: are melanism-inducing mutations in Agouti not found because they occur less often, or are they simply more difficult to detect?
Mc1r Binding (associated) of associated with melanocortin 1 receptor and freckles
5) Confidence 0.47 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2713407 Disease Relevance 0.87 Pain Relevance 0.53
Recently, a novel high-affinity ligand for MC1R was identified in dogs, namely canine ?
MC1R Binding (ligand) of associated with melanocortin 1 receptor
6) Confidence 0.46 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0.16 Pain Relevance 0.42
Physiologic significance of alphaMSH-MC1R interaction in host defense against infection is discussed.
MC1R Binding (interaction) of associated with melanocortin 1 receptor and infection
7) Confidence 0.45 Published 2007 Journal J. Vet. Med. Sci. Section Abstract Doc Link 17917378 Disease Relevance 0.60 Pain Relevance 0.43
Studies using purified full-length agouti signaling protein has shown that it competes with (&agr;)-melanocyte stimulating hormone for binding to the melanocortin 1 receptor.
melanocortin 1 receptor Binding (binding) of in melanocyte associated with melanocortin 1 receptor
8) Confidence 0.45 Published 2001 Journal J. Cell. Sci. Section Abstract Doc Link 11181184 Disease Relevance 0 Pain Relevance 0.45
At this time, the agouti protein binds to the Mc1r, thereby excluding ?
Mc1r Binding (binds) of associated with melanocortin 1 receptor
9) Confidence 0.41 Published 2004 Journal Mol Cancer Section Body Doc Link PMC443512 Disease Relevance 0.34 Pain Relevance 0.19
Attractin is required for ASIP effects in the mouse, and was suggested to function to enhance ASIP–MC1R binding (Barsh, 2006).
MC1R Binding (binding) of associated with melanocortin 1 receptor
10) Confidence 0.40 Published 2009 Journal Pigment Cell & Melanoma Research Section Body Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.19
In humans, melanocortin 1 receptor variants are associated with red hair and fair skin, and work in progress from our laboratory suggests that certain melanocortin 1 receptor variants may preferentially be associated with hair color rather than skin type.
melanocortin 1 receptor Binding (associated) of in skin associated with melanocortin 1 receptor
11) Confidence 0.38 Published 1997 Journal J. Investig. Dermatol. Symp. Proc. Section Abstract Doc Link 9487023 Disease Relevance 0.16 Pain Relevance 0.45
Surprisingly, we found very little overlap between the Mc1r- and the Kit-dependent UVB-responsive genes (only five in common of a total of 267), suggesting that the biological processes engaged by Mc1r signaling in the response to UVB are distinct from the ability of pigment cells to protect against UV radiation by providing a simple physical barrier.
Mc1r Binding (engaged) of in pigment cells
12) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0 Pain Relevance 0
We used two-way analysis of variance (ANOVA) to characterize the interaction between genotype and UVB exposure and identified 120 and 147 genes that showed a significant interaction (p = 0.05) between UVB and Mc1r and between UVB and Kit, respectively.
Mc1r Binding (interaction) of in Kit
13) Confidence 0.37 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.07 Pain Relevance 0
We suggest an interaction between MC1R and TRP channel activation or signaling may occur but whether this may occur through direct or indirect activation needs to be examined.
MC1R Binding (interaction) of associated with trp channel and melanocortin 1 receptor
14) Confidence 0.37 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2938350 Disease Relevance 0.23 Pain Relevance 1.25
Two candidate genes, the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti), map to independent regions that together are responsible for most of the difference in pigmentation between subspecies.
Mc1r Binding (map) of in pigmentation associated with melanocortin 1 receptor and antagonist
15) Confidence 0.37 Published 2007 Journal PLoS Biol Section Abstract Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40
Two candidate genes, the melanocortin-1 receptor (Mc1r) and its antagonist, the Agouti signaling protein (Agouti), map to independent regions that together are responsible for most of the difference in pigmentation between subspecies.
melanocortin-1 receptor Binding (map) of in pigmentation associated with melanocortin 1 receptor and antagonist
16) Confidence 0.37 Published 2007 Journal PLoS Biol Section Abstract Doc Link PMC1945039 Disease Relevance 0 Pain Relevance 0.40
This work provides new insight into the cutaneous response to UV radiation and reveals mechanisms whereby interactions between UV radiation and MC1R signaling may predispose toward the pathogenesis of skin cancer.


MC1R Binding (interactions) of in skin associated with melanocortin 1 receptor and skin cancer
17) Confidence 0.36 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1774588 Disease Relevance 0.19 Pain Relevance 0.18
Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

Melanocortin-1 receptor (MC1R) and its ligands, ?

Melanocortin-1 receptor Binding (ligands) of in melanoblast associated with melanocortin 1 receptor
18) Confidence 0.35 Published 2009 Journal Pigment Cell & Melanoma Research Section Title Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.25
Agouti protein, mahogunin, and attractin in pheomelanogenesis and melanoblast-like alteration of melanocytes: a cAMP-independent pathway

Melanocortin-1 receptor (MC1R) and its ligands, ?

MC1R Binding (ligands) of in melanoblast associated with melanocortin 1 receptor
19) Confidence 0.35 Published 2009 Journal Pigment Cell & Melanoma Research Section Title Doc Link PMC2784899 Disease Relevance 0 Pain Relevance 0.25
Thyrotropin releasing hormone (TRH) selectively binds and activates the melanocortin 1 receptor.
melanocortin 1 receptor Binding (binds) of associated with melanocortin 1 receptor
20) Confidence 0.35 Published 1999 Journal Peptides Section Title Doc Link 10447100 Disease Relevance 0.17 Pain Relevance 0.10

General Comments

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