INT71031

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 2.96
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (ADRB1) plasma membrane (ADRB1) nucleus (ADRB1)
cytoplasm (ADRB1) signal transducer activity (ADRB1)
Anatomy Link Frequency
vasculature 1
lung 1
vas deferens 1
ADRB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 58 97.16 Very High Very High Very High
agonist 26 96.44 Very High Very High Very High
antagonist 10 87.92 High High
adenocard 6 85.88 High High
Calcium channel 2 83.88 Quite High
Inflammation 12 81.92 Quite High
dopamine receptor 1 72.88 Quite High
Clonidine 1 72.60 Quite High
rheumatoid arthritis 2 65.72 Quite High
Dismenorea 1 62.44 Quite High
Disease Link Frequency Relevance Heat
Malaria 246 98.72 Very High Very High Very High
Hypoxia 56 98.52 Very High Very High Very High
Toxicity 13 96.36 Very High Very High Very High
Obesity 2 95.20 Very High Very High Very High
Asthma 6 94.20 High High
Disease 34 91.16 High High
Pulmonary Disease 2 85.16 High High
Parasitemia 54 83.84 Quite High
INFLAMMATION 15 81.92 Quite High
Increased Venous Pressure Under Development 10 77.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The ADRB3 shares 40 to 50% amino acid sequence identity with ADRB1 and ADRB2.
Gene_expression (shares) of ADRB1
1) Confidence 0.55 Published 2007 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC1892055 Disease Relevance 0.45 Pain Relevance 0.23
0.032 and P<0.001 respectively), (ii) ADRB index dichotomized at 300 units (<300 vs ?
Gene_expression (index) of ADRB
2) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.14 Pain Relevance 0
Determination of the standardized ADRB index
Gene_expression (index) of ADRB
3) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0 Pain Relevance 0
The third model (Table 3), using the same cut-off ADRB value of 250 as for Ndiop, was the best (AIC?
Gene_expression (value) of ADRB
4) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.15 Pain Relevance 0
Association between ADRB index and susceptibility to clinical malaria at a meso-endemic site
Gene_expression (index) of ADRB associated with malaria
5) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.25 Pain Relevance 0
Association between ADRB index and susceptibility to clinical malaria at a holo-endemic site
Gene_expression (index) of ADRB associated with malaria
6) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.16 Pain Relevance 0
As for Ndiop, a bivariate analysis showed that the variables significantly associated with the number of clinical attacks were (i) the continuous and dichotomized ADRB index (continuous rate ratio [RR]?
Gene_expression (index) of ADRB
7) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.16 Pain Relevance 0
The data presented here suggest that age-related decreases in the sensitivity to adrenaline and phentolamine (when measured by displacing adrenaline concentration-effect curves) in the whole vas deferens are probably due to a variation in the proportion of alpha(1)-adrenoceptor subtypes in the epididymal portion of the rat vas deferens.
Gene_expression (proportion) of adrenoceptor in vas deferens
8) Confidence 0.07 Published 1997 Journal J Auton Pharmacol Section Abstract Doc Link 9278774 Disease Relevance 0.08 Pain Relevance 0.16
Respirable As-ODNs (RASONs), as compared to systemically administered As-ODNs, offer the potential to selectively downregulate the AR-1 expression in the lung at much smaller doses and also minimize the risk of systemic side effects and toxicity.
Gene_expression (expression) of AR-1 in lung associated with toxicity
9) Confidence 0.05 Published 2008 Journal Gene Regulation and Systems Biology Section Body Doc Link PMC2733095 Disease Relevance 1.12 Pain Relevance 0.29
2-adrenoceptor responsiveness in the pulmonary vasculature during hypoxia [26].
Gene_expression (responsiveness) of adrenoceptor in vasculature associated with hypoxia
10) Confidence 0.03 Published 2001 Journal Crit Care Section Body Doc Link PMC31580 Disease Relevance 0.46 Pain Relevance 0.33

General Comments

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