INT71047

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 4
Speculated 1
Reported most in Abstract
Documents 122
Total Number 124
Disease Relevance 68.78
Pain Relevance 22.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
body 6
endometrium 4
spinal cord 3
nodules 3
stroma 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 18 99.98 Very High Very High Very High
endometriosis 936 99.54 Very High Very High Very High
Osteoarthritis 494 99.54 Very High Very High Very High
rheumatoid arthritis 684 99.48 Very High Very High Very High
Buprenorphine 19 99.40 Very High Very High Very High
methadone 16 99.24 Very High Very High Very High
cINOD 394 99.22 Very High Very High Very High
Dorsal horn 7 99.20 Very High Very High Very High
Inflammation 437 98.60 Very High Very High Very High
Pain 117 98.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Endometriosis 1118 100.00 Very High Very High Very High
Osteopetrosis 144 100.00 Very High Very High Very High
Cancer 1335 99.84 Very High Very High Very High
Reprotox - General 3 595 99.80 Very High Very High Very High
Breast Cancer 1706 99.78 Very High Very High Very High
Frailty 508 99.54 Very High Very High Very High
Endometriosis (extended) 272 99.54 Very High Very High Very High
Rheumatoid Arthritis 684 99.48 Very High Very High Very High
Acidosis 2 99.44 Very High Very High Very High
Targeted Disruption 89 99.42 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Previous studies in our laboratories suggested a strong association between aromatase (CYP19) gene expression and the expression of cyclooxygenase (COX) genes.
Gene_expression (expression) of aromatase
1) Confidence 0.78 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.41 Pain Relevance 0.19
Additionally, nonsteroidal anti-inflammatory drugs (NSAIDs) and COX selective inhibitors can suppress CYP19 gene expression and decrease aromatase activity.
Gene_expression (expression) of CYP19 associated with inflammation and cinod
2) Confidence 0.78 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.47 Pain Relevance 0.20
Thus, these results suggest that the siRNAs and novel sulfonanilides targeting aromatase expression may be valuable tools for selective regulation of aromatase in breast cancer.
Gene_expression (expression) of aromatase associated with breast cancer
3) Confidence 0.78 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.38 Pain Relevance 0
Aromatase expression and enzyme activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue.
Gene_expression (expression) of Aromatase associated with cancer and breast cancer
4) Confidence 0.78 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.33 Pain Relevance 0.13
Previous studies in our laboratories suggested a strong association between aromatase (CYP19) gene expression and the expression of cyclooxygenase (COX) genes.
Gene_expression (expression) of CYP19
5) Confidence 0.78 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.41 Pain Relevance 0.19
Complex regulation of aromatase expression in human tissues involves alternative promoter sites that provide tissue-specific control.
Gene_expression (expression) of aromatase
6) Confidence 0.78 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.35 Pain Relevance 0.15
The determined inhibition constants of methadone and BUP for E(3) formation by a cDNA-expressed CYP19 preparation were similar to those for placental microsomes.
Gene_expression (expressed) of CYP19 associated with methadone and buprenorphine
7) Confidence 0.78 Published 2006 Journal Biochem. Pharmacol. Section Abstract Doc Link 16455059 Disease Relevance 0 Pain Relevance 1.08
Previous studies in our laboratories suggested a strong association between aromatase (CYP19) gene expression and the expression of cyclooxygenase (COX) genes.
Gene_expression (expression) of aromatase
8) Confidence 0.78 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.39 Pain Relevance 0.21
Our hypothesis is that higher levels of COX expression result in higher levels of prostaglandin E2 (PGE2), which in turn increases CYP19 expression through increases in intracellular cyclic AMP levels.
Gene_expression (expression) of CYP19
9) Confidence 0.78 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.47 Pain Relevance 0.31
Real time PCR analysis of aromatase gene expression showed a significant decrease in mRNA levels in treated cells when compared to vehicle control.
Gene_expression (expression) of aromatase gene
10) Confidence 0.78 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.50 Pain Relevance 0.33
Previous studies in our laboratories suggested a strong association between aromatase (CYP19) gene expression and the expression of cyclooxygenase (COX) genes.
Gene_expression (expression) of CYP19
11) Confidence 0.78 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.39 Pain Relevance 0.21
Regulation of aromatase expression in human tissues is quite complex, involving alternative promoter sites that provide tissue-specific control.
Gene_expression (expression) of aromatase
12) Confidence 0.78 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.38 Pain Relevance 0.11
Aromatase expression and enzyme activity in breast cancer patients is greater in or near the tumor tissue compared with the normal breast tissue.
Gene_expression (expression) of Aromatase associated with cancer and breast cancer
13) Confidence 0.78 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.27 Pain Relevance 0
The effects of NSAIDs (ibuprofen, piroxicam, and indomethacin), a COX-1 selective inhibitor (SC-560), and COX-2 selective inhibitors (celecoxib, niflumic acid, nimesulide, NS-398, and SC-58125) on aromatase activity and CYP19 expression were investigated in breast cancer cell culture systems.
Gene_expression (expression) of CYP19 associated with breast cancer and cinod
14) Confidence 0.78 Published 2005 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 15964185 Disease Relevance 0.48 Pain Relevance 0.36
Kinetic analysis of a cDNA-expressed CYP19 for the metabolism of methadone to EDDP was identical to that by placental microsomes.
Gene_expression (expressed) of CYP19 associated with methadone
15) Confidence 0.77 Published 2004 Journal Biochem. Pharmacol. Section Abstract Doc Link 15242824 Disease Relevance 0 Pain Relevance 0.62
These data mainly collected in quail, a useful model in neuroendocrinology, demonstrate that numerous neurons in the superficial laminae of the spinal cord express aromatase (estrogen-synthase).
Gene_expression (express) of aromatase in spinal cord associated with spinal cord
16) Confidence 0.77 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16914420 Disease Relevance 0.41 Pain Relevance 0.33
The expression of aromatase in the spinal cord in other species and in other central nociception-related areas is also briefly discussed.
Gene_expression (expression) of aromatase in spinal cord associated with nociception and spinal cord
17) Confidence 0.77 Published 2006 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 16914420 Disease Relevance 0.72 Pain Relevance 0.61
Aromatase overexpression has recently been detected in endometriotic tissue.
Gene_expression (overexpression) of Aromatase associated with endometriosis
18) Confidence 0.77 Published 2005 Journal Eur. J. Obstet. Gynecol. Reprod. Biol. Section Abstract Doc Link 16157442 Disease Relevance 0.59 Pain Relevance 0.25
Recently, aromatase overexpression has been detected in endometriotic tissue.
Gene_expression (overexpression) of aromatase associated with endometriosis
19) Confidence 0.77 Published 2003 Journal Zentralbl Gynakol Section Abstract Doc Link 14505258 Disease Relevance 0.59 Pain Relevance 0.25
Expression of aromatase cytochrome P450 protein and messenger ribonucleic acid in human endometriotic and adenomyotic tissues but not in normal endometrium.
Gene_expression (Expression) of aromatase in endometrium associated with endometriosis and dismenorea
20) Confidence 0.76 Published 1997 Journal Biol. Reprod. Section Title Doc Link 9282984 Disease Relevance 0.85 Pain Relevance 0.46

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