INT71048

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Context Info
Confidence 0.72
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 8.74
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYP19A1) small molecule metabolic process (CYP19A1) endoplasmic reticulum (CYP19A1)
cytoplasm (CYP19A1)
Anatomy Link Frequency
endometrium 2
CYP19A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 91 99.22 Very High Very High Very High
Dismenorea 22 97.72 Very High Very High Very High
endometriosis 102 97.42 Very High Very High Very High
COX-2 inhibitor 113 82.80 Quite High
aspirin 37 80.52 Quite High
cytokine 32 64.32 Quite High
Inflammation 56 50.00 Quite Low
COX2 4 50.00 Quite Low
Paracetamol 15 20.24 Low Low
Calcium channel 1 16.24 Low Low
Disease Link Frequency Relevance Heat
Breast Cancer 75 99.70 Very High Very High Very High
Endometriosis 159 99.64 Very High Very High Very High
Reprotox - General 1 6 97.16 Very High Very High Very High
Metastasis 7 95.88 Very High Very High Very High
Adhesions 17 95.36 Very High Very High Very High
Gynecological Disease 4 95.20 Very High Very High Very High
INFLAMMATION 66 93.04 High High
Malignant Neoplastic Disease 7 91.08 High High
Apoptosis 159 90.56 High High
Lymphatic System Cancer 4 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Real-time PCR analysis demonstrates that the sulfonanilide analogs decrease aromatase gene transcription in breast cells.
Transcription (transcription) of aromatase gene
1) Confidence 0.72 Published 2007 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 17616393 Disease Relevance 0.30 Pain Relevance 0
To determine whether local estrogen production takes place in endometriotic or adenomyotic tissues, in eutopic endometrium from patients with endometriosis or adenomyosis, and in normal endometrium, tissue specimens were examined by immunohistochemistry, catalytic activity, and mRNA expression for aromatase cytochrome P450 (P450arom).
Transcription (expression) of P450arom in endometrium associated with endometriosis and dismenorea
2) Confidence 0.70 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9282984 Disease Relevance 0.88 Pain Relevance 0.48
However, neither P450arom protein activity nor mRNA was detected in endometrial specimens obtained from normal menstruating women with cervical carcinoma in situ but without any other gynecological disease.
Transcription (detected) of P450arom associated with gynecological disease and reprotox - general 1
3) Confidence 0.70 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9282984 Disease Relevance 0.91 Pain Relevance 0.48
To determine whether local estrogen production takes place in endometriotic or adenomyotic tissues, in eutopic endometrium from patients with endometriosis or adenomyosis, and in normal endometrium, tissue specimens were examined by immunohistochemistry, catalytic activity, and mRNA expression for aromatase cytochrome P450 (P450arom).
Transcription (expression) of aromatase in endometrium associated with endometriosis and dismenorea
4) Confidence 0.70 Published 1997 Journal Biol. Reprod. Section Abstract Doc Link 9282984 Disease Relevance 0.87 Pain Relevance 0.48
It has recently been discovered that up-regulation of COX-2 and correlative production of prostaglandin E2 (PGE2) effectively and specifically induces the promoter II region of the cytochrome P-450 gene (CYP-19) which is transcribed and translated into aromatase, the chief enzyme in the biosynthesis of estrogen 47, 48.
Transcription (transcribed) of CYP-19
5) Confidence 0.46 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1893117 Disease Relevance 0.79 Pain Relevance 0
It has recently been discovered that up-regulation of COX-2 and correlative production of prostaglandin E2 (PGE2) effectively and specifically induces the promoter II region of the cytochrome P-450 gene (CYP-19) which is transcribed and translated into aromatase, the chief enzyme in the biosynthesis of estrogen 47, 48.
Transcription (transcribed) of aromatase
6) Confidence 0.44 Published 2007 Journal International Journal of Biological Sciences Section Body Doc Link PMC1893117 Disease Relevance 0.79 Pain Relevance 0
Both NSAIDs and COX-selective inhibitors suppress aromatase mRNA expression and enzyme activity in breast cancer cells.
Transcription (expression) of aromatase associated with breast cancer and cinod
7) Confidence 0.13 Published 2006 Journal Minerva Endocrinol. Section Abstract Doc Link 16498361 Disease Relevance 0.68 Pain Relevance 0.29
Of particular relevance to breast cancer, PGs can increase estrogen biosynthesis via upregulation of aromatase transcription (discussed below).
Transcription (transcription) of aromatase associated with breast cancer
8) Confidence 0.10 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2206709 Disease Relevance 1.09 Pain Relevance 0
Indeed, the expression of uncontrolled aromatase mRNA in endometriotic lesions [36] suggests that a local estrogenic milieu is important in the development of endometriosis.
Transcription (expression) of aromatase associated with endometriosis
9) Confidence 0.07 Published 2003 Journal Reprod Biol Endocrinol Section Body Doc Link PMC305339 Disease Relevance 1.00 Pain Relevance 0.19
Research conducted across several vertebrate classes has shown that atrazine exposure can inhibit androgen production and increase estrogens by increasing aromatase transcription (Crain et al. 1997; Fan et al. 2007; Sanderson et al. 2002).
Transcription (transcription) of aromatase
10) Confidence 0.06 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592273 Disease Relevance 0.28 Pain Relevance 0
Moreover, prostaglandins were able to increase cell proliferation of hormonal-dependent breast cancer by increasing transcription of CYP19 aromatase implicated in estrogen biosynthesis [87].
Transcription (transcription) of CYP19 aromatase associated with breast cancer
11) Confidence 0.03 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.15 Pain Relevance 0.33

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