INT711

Context Info Confidence 0.70 First Reported 1975 Last Reported 2010 Negated 4 Speculated 3 Reported most in Abstract Documents 83 Total Number 86 Disease Relevance 76.87 Pain Relevance 13.18

Golgi apparatus (PIK3C2A) plasma membrane (PIK3C2A) nucleus (PIK3C2A) cytoplasm (PIK3C2A)

Anatomy Link Frequency muscle 6 plasma 4 liver 4 blood 2 skin 2 PIK3C2A (Homo sapiens)

Pain Link Frequency Relevance Heat Pain 95 99.96 headache 27 98.84 corticosteroid 15 98.84 lidocaine 18 98.68 cva 12 97.92 neuralgia 4 97.92 Angina 35 97.62 Duloxetine 250 97.56 anesthesia 15 97.54 antagonist 4 97.08

Disease Link Frequency Relevance Heat Disorders Of Creatine Metabolism 124 100.00 Pain 55 99.96 Thrombosis 3 99.96 Left Ventricular Dysfunction 1 99.96 Hypertension 14 99.92 Muscle Disease 42 99.90 Muscle Weakness 14 99.90 Arthralgia 4 99.90 Acute Coronary Syndrome 11 99.88 Ulcers 5 99.88

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The only sign consistent with a possible myocardial involvement was a slight increase in serum CPK.

Positive_regulation (increase) of CPK

1) Confidence 0.70 Published 1993 Journal G Ital Cardiol Section Abstract Doc Link 8405820 Disease Relevance 0.68 Pain Relevance 0.13

A significant rise in serum creatine phosphokinase (CPK) level was noted at the 6th hour (p < 0.01), on the 1st day (p < 0.001) and on the 2nd day (p < 0.05) after aortography.

Positive_regulation (rise) of CPK associated with disorders of creatine metabolism

2) Confidence 0.67 Published 1980 Journal Anesth Analg (Paris) Section Abstract Doc Link 7469057 Disease Relevance 0.31 Pain Relevance 0

The patients with history of previous myocardial infarction, pathological Q waves on electrocardiogram or documented elevation of CPK were excluded.

Positive_regulation (elevation) of CPK associated with myocardial infarction

3) Confidence 0.67 Published 1992 Journal G Ital Cardiol Section Abstract Doc Link 1426810 Disease Relevance 0.46 Pain Relevance 0.26

Chest x-ray film showed infiltration of the right upper lung field and blood exam demonstrated marked increase in CPK and renal dysfunction.

Positive_regulation (increase) of CPK in lung associated with renal disease

4) Confidence 0.67 Published 2007 Journal Nihon Kokyuki Gakkai Zasshi Section Abstract Doc Link 17554986 Disease Relevance 1.14 Pain Relevance 0.09

After the patient experienced muscle pain in his thighs and shoulders after exercise on February 11, 1991, the serum creatine phosphokinase (CPK) level progressively increased up to 2,329 U/l.

Positive_regulation (increased) of CPK in thighs associated with pain, disorders of creatine metabolism and myalgia

5) Confidence 0.67 Published 1992 Journal Hinyokika Kiyo Section Abstract Doc Link 1481777 Disease Relevance 0.86 Pain Relevance 0.10

Side effects were observed in 6 patients--in 4 of them a minor increase of ALAT, AsPAT or CPK activities (less than 3 times above norm were observed) without any symptoms and with a spontaneous normalization with no need to stop treatment, and in 2 of them abdominal pains not causing drug treatment cessation.

Positive_regulation (increase) of CPK associated with abdominal pain

6) Confidence 0.67 Published 1991 Journal Kardiol Pol Section Abstract Doc Link 1942761 Disease Relevance 0.65 Pain Relevance 0.09

The patient's father was found to have undiagnosed muscle pain and an elevated CPK level.

Positive_regulation (elevated) of CPK in muscle associated with pain and myalgia

7) Confidence 0.67 Published 1991 Journal Anaesthesist Section Abstract Doc Link 1867372 Disease Relevance 1.74 Pain Relevance 0.26

No complications were seen during anaesthesia and the following immediate postoperative period. 10 hrs after surgery an episode of pyrexia lasting about 20 h and an elevation of blood creatine phosphokinase (CPK) has been noted.

Positive_regulation (elevation) of CPK in blood associated with disorders of creatine metabolism and fever

8) Confidence 0.67 Published 1985 Journal Anaesthesist Section Abstract Doc Link 3993899 Disease Relevance 0.43 Pain Relevance 0.25

Increases in CPK were observed in the S group (4.8% of patients) and in the L group (11.9%).

Positive_regulation (Increases) of CPK

9) Confidence 0.67 Published 1991 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 1904357 Disease Relevance 0.92 Pain Relevance 0.39

We report our results observed in 14 patients aged 48 to 75 years admitted to the coronary care unit with a diagnosis of acute coronary insufficiency defined as typical persistent anginal pain resistant to glyceryl trinitrate associated with specific ECG changes (without pathological Q waves or increased serum CPK concentrations).

Neg (without) Positive_regulation (increased) of CPK associated with cv unclassified under development and cva

10) Confidence 0.67 Published 1985 Journal Arch Mal Coeur Vaiss Section Abstract Doc Link 3935083 Disease Relevance 0.82 Pain Relevance 0.12

Increased activity of a muscular enzymes creatine kinase (CPK) could be detected in 27 patients and increased activity of lactic acid dehydrogenase (LDH) in 9 patients.

Positive_regulation (Increased) of CPK

11) Confidence 0.67 Published 1992 Journal Przegl Epidemiol Section Abstract Doc Link 1296244 Disease Relevance 0.82 Pain Relevance 0.20

Serum levels of aldose, CPK, ASAT and ALAT were increased but ordinary light microscopy revealed no histological signs of muscle disease in a quadriceps biopsy.

Positive_regulation (increased) of CPK in quadriceps associated with muscle disease

12) Confidence 0.67 Published 1975 Journal Acta Med Scand Section Abstract Doc Link 1166819 Disease Relevance 0.74 Pain Relevance 0.09

One recent study demonstrated that red yeast rice and lifestyle modification can decrease LDL levels without increasing creatinine phosphokinase (CPK) or pain levels.

Neg (without) Positive_regulation (increasing) of CPK associated with pain

13) Confidence 0.67 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2823761 Disease Relevance 0.54 Pain Relevance 0.14

The two patients presented 13 and 19 months after allogeneic transplantation with characteristic features of muscular hypotrophy, proximal muscle weakness, pain, elevated creatine phosphokinase (CPK), aldolase and SGPT.

Positive_regulation (elevated) of CPK in muscle associated with pain, disorders of creatine metabolism and muscle weakness

14) Confidence 0.67 Published 2002 Journal Bone Marrow Transplant. Section Abstract Doc Link 12379897 Disease Relevance 1.29 Pain Relevance 0.10

Serum creatine phosphokinase (CPK) was markedly increased in all cases.

Positive_regulation (increased) of CPK associated with disorders of creatine metabolism

15) Confidence 0.67 Published 1979 Journal Neurology Section Abstract Doc Link 572938 Disease Relevance 0.84 Pain Relevance 0.10

Using multivariate analysis, negative prognostic factors were higher age (p < 0.001), advanced Killip class at admission (p < 0.001) and elevated peak CPK levels (p < 0.001).

Positive_regulation (elevated) of CPK

16) Confidence 0.67 Published 1997 Journal Schweiz Med Wochenschr Section Abstract Doc Link 9333939 Disease Relevance 0.87 Pain Relevance 0.19

She complained numbness and ardor on her hand with motor nerve disturbance and plasma CPK level was elevated.

Positive_regulation (elevated) of CPK in plasma associated with hypesthesia

17) Confidence 0.67 Published 1997 Journal Masui Section Abstract Doc Link 9028095 Disease Relevance 0.68 Pain Relevance 0.11

CPK was elevated in nine patients (up to 30,000); in six patients CPK was not determined.

Positive_regulation (elevated) of CPK

18) Confidence 0.67 Published 1995 Journal Langenbecks Arch Chir Section Abstract Doc Link 8558998 Disease Relevance 0.66 Pain Relevance 0.14

ECG revealed myocardial infarction-like ST-elevation in II, III, aVF, V4, V5, and V6 but coronary angiography revealed no abnormal findings in the right and left coronary arteries, and no elevation of SGOT, LDH or CPK was found.

Neg (no) Positive_regulation (elevation) of CPK associated with myocardial infarction

19) Confidence 0.67 Published 1993 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 8331849 Disease Relevance 0.75 Pain Relevance 0.09

CPK was mildly elevated in only 3 patients.

Positive_regulation (elevated) of CPK

20) Confidence 0.67 Published 1993 Journal Arq Neuropsiquiatr Section Abstract Doc Link 8274073 Disease Relevance 1.93 Pain Relevance 0.16

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