INT71101

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Context Info
Confidence 0.50
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.53
Pain Relevance 1.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Grip2) plasma membrane (Grip2) cytoskeleton (Grip2)
cytoplasm (Grip2)
Anatomy Link Frequency
cerebral cortex 2
forebrain 2
Grip2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 48 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
Lasting pain 2 99.98 Very High Very High Very High
nMDA receptor 1 99.80 Very High Very High Very High
Pain 5 99.20 Very High Very High Very High
tetrodotoxin 1 99.08 Very High Very High Very High
excitatory amino acid 2 99.04 Very High Very High Very High
cerebral cortex 1 98.58 Very High Very High Very High
GABAergic 17 84.48 Quite High
Glutamate receptor 5 81.28 Quite High
Disease Link Frequency Relevance Heat
Pain 5 99.98 Very High Very High Very High
Stress 1 98.12 Very High Very High Very High
Headache 2 89.84 High High
Peripheral Arterial Disease 1 83.76 Quite High
Anxiety Disorder 10 5.00 Very Low Very Low Very Low
Schizophrenia 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Paranoid Disorders 1 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low
Gliosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation of presynaptic AMPA receptors by the endogenous agonist L-glutamate, or by (R,S)-AMPA, dose-dependently enhanced the Ca(2+)-dependent, tetrodotoxin-insensitive, electrically-stimulated release of [3H]D-aspartate from rat forebrain slices.
Positive_regulation (enhanced) of Positive_regulation (Stimulation) of AMPA in forebrain associated with tetrodotoxin, glutamate and agonist
1) Confidence 0.50 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9286615 Disease Relevance 0 Pain Relevance 0.34
Previous studies have demonstrated that there is an increase in oxidative stress in the cerebral cortex of rats after repeated painful stimulation and that long-lasting pain increases the production of superoxide ion (O(2) (-)), nitric oxide and peroxynitrite due to the activation of AMPA and NMDA receptors.
Positive_regulation (increases) of Positive_regulation (activation) of AMPA in cerebral cortex associated with stress, pain, nmda receptor, lasting pain and cerebral cortex
2) Confidence 0.07 Published 2010 Journal Mol. Cell. Biochem. Section Abstract Doc Link 20058053 Disease Relevance 0.53 Pain Relevance 0.54
As a caveat, it may be important to note that our conclusion that glutamate disruption fails to penetrate core ‘liking’ reactions to sensory pleasure is specific to ionotropic glutamate signals, and in particular to those requiring AMPA receptor activation.
Positive_regulation (requiring) of Positive_regulation (activation) of AMPA receptor associated with glutamate
3) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2887893 Disease Relevance 0 Pain Relevance 0.38

General Comments

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