INT71109

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Context Info
Confidence 0.01
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.27

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pigmentation (MC1R) plasma membrane (MC1R) signal transducer activity (MC1R)
Anatomy Link Frequency
TM4 1
INSRR (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 15 100.00 Very High Very High Very High
Potency 12 80.36 Quite High
agonist 9 80.04 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These experiments appear to have identified some of the critical receptor residues involved in the ligand-receptor interactions between these melanocortins and the hMC1R.
receptor Binding (interactions) of MC1R
1) Confidence 0.01 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9287296 Disease Relevance 0 Pain Relevance 0.39
These experiments appear to have identified some of the critical receptor residues involved in the ligand-receptor interactions between these melanocortins and the hMC1R.
receptor Binding (interactions) of MC1R
2) Confidence 0.01 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9287296 Disease Relevance 0 Pain Relevance 0.40
In addition, results from the individual mutation of aromatic receptor residues Phe175, Phe196, and Phe257, and simultaneous mutation of multiple TM4, -5, and -6 tyrosine and phenylalanine residues suggests that aromatic-aromatic ligand-receptor interactions also participate in binding these melanocortins to the MC1R.
receptor Binding (binding) of MC1R in TM4 associated with melanocortin 1 receptor
3) Confidence 0.01 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9287296 Disease Relevance 0 Pain Relevance 0.48

General Comments

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