INT71110

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Context Info
Confidence 0.10
First Reported 1997
Last Reported 1997
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.57

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cell-cell signaling (NDP) signal transducer activity (MC1R) pigmentation (MC1R)
cell proliferation (NDP) extracellular space (NDP) signal transduction (NDP)
MC1R (Homo sapiens)
NDP (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 5 100.00 Very High Very High Very High
Potency 4 96.36 Very High Very High Very High
agonist 3 80.72 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test a previously constructed three-dimensional model of the molecular interaction between the long-acting, superpotent alpha-MSH analog [Nle4,D-Phe7]MSH (NDP-MSH) and the human MC1R we examined the effects of site-directed receptor mutagenesis on the binding affinity and potency of NDP-MSH.
MC1R Spec (examined) Binding (interaction) of NDP-MSH associated with melanocortin 1 receptor and potency
1) Confidence 0.10 Published 1997 Journal J. Biol. Chem. Section Abstract Doc Link 9287296 Disease Relevance 0 Pain Relevance 0.57

General Comments

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