INT71115

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.70
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 20
Total Number 20
Disease Relevance 15.32
Pain Relevance 1.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpine1) extracellular region (Serpine1)
Anatomy Link Frequency
blood 4
plasma 2
brain 2
platelet 2
endometrium 2
Serpine1 (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 63 98.48 Very High Very High Very High
COX-2 inhibitor 2 98.34 Very High Very High Very High
Arthritis 108 98.32 Very High Very High Very High
cytokine 57 96.68 Very High Very High Very High
Inflammation 114 96.32 Very High Very High Very High
Glutamate 3 96.00 Very High Very High Very High
Neurotransmitter 1 94.20 High High
Central nervous system 28 93.24 High High
agonist 88 92.28 High High
cva 3 92.24 High High
Disease Link Frequency Relevance Heat
Hypothermia 322 99.98 Very High Very High Very High
Stroke 81 99.70 Very High Very High Very High
Endotoxemia 147 99.56 Very High Very High Very High
Malignant Neoplastic Disease 3 99.16 Very High Very High Very High
Thrombosis 239 98.76 Very High Very High Very High
Breast Cancer 36 98.72 Very High Very High Very High
Increased Venous Pressure Under Development 8 98.64 Very High Very High Very High
Injury 18 98.60 Very High Very High Very High
Internal Fibrosis 2 98.48 Very High Very High Very High
Arthritis 112 98.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, we have reported that PAI-1 gene expression was markedly enhanced locally in cardiovascular cells immediately after injecting (i.p.) mice with kainate, an analog of glutamate, which is the principal excitatory neurotransmitter in the central nervous system.
Positive_regulation (enhanced) of Gene_expression (expression) of PAI-1 gene in central nervous system associated with neurotransmitter, glutamate and central nervous system
1) Confidence 0.70 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 15850565 Disease Relevance 0.10 Pain Relevance 0.14
Stroke significantly increased expression of tPA and PAI-1 in the ischemic hemisphere compared to non-ischemic brain (Fig. 4a, 4b).
Positive_regulation (increased) of Gene_expression (expression) of PAI in brain associated with stroke
2) Confidence 0.69 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.75 Pain Relevance 0
For the first time, we now provide evidence that the expression of PAI-1 is increased in the systemic circulation and thrombus formation in endotoxemia is enhanced by moderate systemic hypothermia.
Positive_regulation (increased) of Gene_expression (expression) of PAI associated with hypothermia, endotoxemia and thrombosis
3) Confidence 0.58 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.96 Pain Relevance 0
PAI-1 expression of IHC was slightly increased at 5-day.
Positive_regulation (increased) of Gene_expression (expression) of PAI-1
4) Confidence 0.47 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 0.51 Pain Relevance 0.19
Elevated PAI-1 expression inhibits tPA activity and reduces injury from stroke [72], [73].
Positive_regulation (Elevated) of Gene_expression (expression) of PAI associated with stroke and injury
5) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.94 Pain Relevance 0.12
Our in vitro studies which mimic ischemic conditions show increased tPA and PAI-1 expression in OGD astrocytes, and that MSC-astrocyte co-culture concomitantly decreased the PAI-1 expression and increased tPA activity in astrocytes.
Positive_regulation (increased) of Gene_expression (expression) of PAI in astrocytes
6) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2815778 Disease Relevance 0.94 Pain Relevance 0.08
Endotoxemia resulted in a marked increase in the expression of P-selectin and PAI-1 within the microvascular endothelium.
Positive_regulation (increase) of Gene_expression (expression) of PAI in endothelium associated with endotoxemia
7) Confidence 0.42 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.46 Pain Relevance 0
We carried out experiments to investigate whether the COX-2 inhibitor celecoxib at a dose of either 200 mg bid or 400 mg bid could significantly affect endogenous uPA, PAI-1 or PGE2 production in women at increased risk for breast cancer.
Positive_regulation (endogenous) of Gene_expression (production) of PAI-1 associated with breast cancer and cox-2 inhibitor
8) Confidence 0.42 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 0.17 Pain Relevance 0.05
The acceleration of thrombus formation observed in endotoxemic and hypothermic animals may, therefore, at least in part, be due to the increase in endothelial PAI-1 expression and plasma concentration.
Positive_regulation (increase) of Gene_expression (expression) of PAI in plasma associated with thrombosis
9) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.98 Pain Relevance 0
Because hypothermia in general is known to slow down physiological processes, it is possible that hypothermia causes an increase in endothelial PAI-1 expression, while secretion into systemic blood circulation is decelerated or even impaired.
Positive_regulation (causes) of Gene_expression (expression) of PAI in blood associated with hypothermia
10) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.96 Pain Relevance 0
Because hypothermia in general is known to slow down physiological processes, it is possible that hypothermia causes an increase in endothelial PAI-1 expression, while secretion into systemic blood circulation is decelerated or even impaired.
Positive_regulation (increase) of Gene_expression (expression) of PAI in blood associated with hypothermia
11) Confidence 0.39 Published 2006 Journal Crit Care Section Body Doc Link PMC1751084 Disease Relevance 0.96 Pain Relevance 0
Systemic hypothermia increases PAI-1 expression and accelerates microvascular thrombus formation in endotoxemic mice

Introduction

Positive_regulation (increases) of Gene_expression (expression) of PAI associated with hypothermia and thrombosis
12) Confidence 0.39 Published 2006 Journal Crit Care Section Title Doc Link PMC1751084 Disease Relevance 0.95 Pain Relevance 0.03
Of interest, hypothermia did not affect endothelial receptor expression and platelet reactivity, but increased endothelial PAI-1 expression and, in particular, soluble PAI-1 antigen (sPAI-Ag) plasma levels.


Neg (not) Positive_regulation (increased) of Gene_expression (expression) of PAI in platelet associated with hypothermia
13) Confidence 0.39 Published 2006 Journal Crit Care Section Abstract Doc Link PMC1751084 Disease Relevance 0.94 Pain Relevance 0.04
When PAI-1 expression was restored, invasion and associated angiogenesis were also restored, suggesting that host-produced PAI-1 is essential for cancer cell invasion and angiogenesis [10].
Positive_regulation (restored) of Gene_expression (expression) of PAI-1 associated with cancer
14) Confidence 0.39 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2580770 Disease Relevance 1.51 Pain Relevance 0
induce PAI-1 expression, and inhibition of these compounds resulted in decreased PAI-1 and sclerosis in experimental models of chronic kidney disease (18-20).
Positive_regulation (induce) of Gene_expression (expression) of PAI-1 in kidney associated with chronic renal failure and sclerosis
15) Confidence 0.31 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2799997 Disease Relevance 1.11 Pain Relevance 0.38
Although older subjects were more severely ill, we observed lower circulating PAI-1 levels among older subjects in our study.
Positive_regulation (circulating) of Gene_expression (levels) of PAI-1
16) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2973976 Disease Relevance 0.83 Pain Relevance 0.14
Atorvastatin increased Smad3 phosphorylation associated to elevated PAI-1 expression, collagen deposition and SMA staining, indicating that the TGF-?
Positive_regulation (elevated) of Gene_expression (expression) of PAI-1
17) Confidence 0.13 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2597201 Disease Relevance 0.56 Pain Relevance 0.03
PAI-1 mRNA expression was increased (6.5-fold; P < 0.001) in all CP samples.
Positive_regulation (increased) of Gene_expression (expression) of PAI-1 mRNA
18) Confidence 0.10 Published 1997 Journal Gastroenterology Section Body Doc Link 9287983 Disease Relevance 0.08 Pain Relevance 0
CONCLUSIONS: The slow levonorgestrel-release intrauterine device use results in high expression of fibrinolytic inhibitors (PAI-1/2) and upregulated u-PAR expression in the endometrium.
Positive_regulation (results) of Gene_expression (expression) of PAI-1 in endometrium
19) Confidence 0.07 Published 2007 Journal J. Thromb. Haemost. Section Body Doc Link 17010149 Disease Relevance 0 Pain Relevance 0
In addition, adenoviral gene transfer of a urokinase plasminogen inhibitor was also able to inhibit angiogenesis in a CIA model [118].


Positive_regulation (transfer) of Gene_expression (transfer) of plasminogen inhibitor associated with arthritis
20) Confidence 0.01 Published 2008 Journal Mod Rheumatol Section Body Doc Link PMC2275302 Disease Relevance 1.62 Pain Relevance 0.77

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox