INT71116

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 29
Total Number 32
Disease Relevance 4.94
Pain Relevance 6.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plau) signal transduction (Plau) extracellular space (Plau)
extracellular region (Plau) kinase activity (Plau)
Anatomy Link Frequency
nerve 1
epithelial cells 1
Plau (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 23 100.00 Very High Very High Very High
Eae 8 99.56 Very High Very High Very High
Morphine 15 99.06 Very High Very High Very High
cocaine 91 99.02 Very High Very High Very High
Sciatic nerve 37 97.12 Very High Very High Very High
Dopamine 6 97.00 Very High Very High Very High
Dismenorea 7 96.40 Very High Very High Very High
cva 6 92.64 High High
Peripheral nerve injury 3 92.00 High High
Nucleus accumbens 10 87.52 High High
Disease Link Frequency Relevance Heat
Adhesions 7 99.92 Very High Very High Very High
Injury 35 98.72 Very High Very High Very High
Endometriosis 2 96.40 Very High Very High Very High
Dysmenorrhea 6 95.32 Very High Very High Very High
Cancer 13 95.24 Very High Very High Very High
Pancreatitis 4 95.12 Very High Very High Very High
Nervous System Injury 4 94.76 High High
Apoptosis 9 92.80 High High
Hemorrhage 10 92.64 High High
Abruptio Placentae 6 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest that that increased uPA expression with repeated drug exposure produces conditions for enhanced acquisition of cocaine-induced CPP, indicating that cocaine-induced CPP and reinstatement may be dependent on active extracellular uPA.
Gene_expression (expression) of uPA associated with cocaine
1) Confidence 0.77 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.41
We show that overexpression of uPA in the Nac significantly augments cocaine-induced place preference.
Gene_expression (overexpression) of uPA associated with cocaine
2) Confidence 0.77 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.64
Cocaine and many other psychostimulants strongly induce urokinase-type plasminogen activator (uPA) expression in the mesolimbic dopaminergic pathway, which plays a major role in drug-mediated behavioral plasticity [Bahi A, Boyer F, Gumy C, Kafri T, Dreyer JL.
Gene_expression (expression) of uPA associated with cocaine
3) Confidence 0.77 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.24
Inhibition of this serine protease expression using doxycycline abolished the augmented acquisition produced by overexpression of uPA but not the expression of the cocaine-induced CPP.
Gene_expression (overexpression) of uPA associated with cocaine
4) Confidence 0.77 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.64
In this study, the role of mesolimbic dopamine (DA) pathways in the development of cocaine reward was examined by conditioned-place preference in rats with bilateral intra-accumbens injections of uPA-expressing lentiviral vectors.
Gene_expression (expressing) of uPA associated with dopamine and cocaine
5) Confidence 0.77 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.62
Cocaine and many other psychostimulants strongly induce urokinase-type plasminogen activator (uPA) expression in the mesolimbic dopaminergic pathway, which plays a major role in drug-mediated behavioral plasticity [Bahi A, Boyer F, Gumy C, Kafri T, Dreyer JL.
Gene_expression (expression) of urokinase associated with cocaine
6) Confidence 0.77 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.24
This study was undertaken to characterize the expression of both uPA and its receptor (uPAR) in the eutopic and heterotopic endometrial cells from women with adenomyosis by testing both types of epithelial cells for invasive ability.
Gene_expression (expression) of uPA in epithelial cells associated with dismenorea
7) Confidence 0.45 Published 2000 Journal Gynecol. Obstet. Invest. Section Abstract Doc Link 11093058 Disease Relevance 0.37 Pain Relevance 0.10
It is also reported that the highly expressed uPA in the epidermal of damaged tissue is regulated by FGF-2 which affects MAPK kinase kinase (MEKK-1) and MEKK-1's downstream NH2-terminal kinases (JNK), and extracellular signal-regulated (ERK) for controlling uPA activity [22–24].
Gene_expression (expressed) of uPA
8) Confidence 0.45 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0
The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner.
Gene_expression (expressions) of uPA
9) Confidence 0.45 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
RESULTS: The OA patients had significantly higher uPA activity and levels of uPA (median 80.01 ng/L), suPAR (median 7.54 ng/L), and PAI-1 (median 54.9 ng/mL) than the healthy control subjects (median 20.47 ng/L uPA, 2.34 ng/L suPAR, and 19.9 ng/mL PAI-1; (P < .05).
Gene_expression (levels) of uPA
10) Confidence 0.36 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.14 Pain Relevance 0
The uPA activity and levels of uPA, suPAR, and PAI-1 were significantly decreased after SH injections in TMJs of OA patients (P < .05), and there was no difference after saline injection.
Gene_expression (levels) of uPA
11) Confidence 0.36 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.12 Pain Relevance 0
Danshen activated the FGF-signaling pathway as evidenced by increased levels of FGF-2 and uPA.
Gene_expression (levels) of uPA
12) Confidence 0.35 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
As shown in Figure 3(a), representing the protein level results, administration of danshen and tanshinone IIA increased the level of FGF-2, MMP 9, and uPA but decreased the level of PAI-1.
Gene_expression (level) of uPA
13) Confidence 0.35 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0.07 Pain Relevance 0
RESULTS: The OA patients had significantly higher uPA activity and levels of uPA (median 80.01 ng/L), suPAR (median 7.54 ng/L), and PAI-1 (median 54.9 ng/mL) than the healthy control subjects (median 20.47 ng/L uPA, 2.34 ng/L suPAR, and 19.9 ng/mL PAI-1; (P < .05).
Gene_expression (levels) of uPA
14) Confidence 0.31 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.14 Pain Relevance 0
The uPA activity and levels of uPA, suPAR, and PAI-1 were significantly decreased after SH injections in TMJs of OA patients (P < .05), and there was no difference after saline injection.
Gene_expression (activity) of uPA
15) Confidence 0.31 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.12 Pain Relevance 0
RESULTS: The OA patients had significantly higher uPA activity and levels of uPA (median 80.01 ng/L), suPAR (median 7.54 ng/L), and PAI-1 (median 54.9 ng/mL) than the healthy control subjects (median 20.47 ng/L uPA, 2.34 ng/L suPAR, and 19.9 ng/mL PAI-1; (P < .05).
Gene_expression (activity) of uPA
16) Confidence 0.31 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.14 Pain Relevance 0
In contrast, tPA-overexpressing animals when administered amphetamine or morphine showed greater place preference compared with uPA-overexpressing animals.
Gene_expression (overexpressing) of uPA associated with morphine
17) Confidence 0.16 Published 2008 Journal Genes Brain Behav. Section Abstract Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.59
Furthermore, animals infected with lentiviruses expressing uPA show enhanced conditional place preference for cocaine compared with tPA-overexpressing animals.
Gene_expression (expressing) of uPA associated with cocaine
18) Confidence 0.16 Published 2008 Journal Genes Brain Behav. Section Abstract Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.58
METHODS: Using Northern blot analysis, in situ hybridization, and immunohistochemistry, the expression of uPA, its receptor (uPAR), plasminogen activator inhibitor 1 (PAI-1), and transforming growth factor beta 1 (TGF-beta 1) was studied in 14 patients undergoing pancreatic resection for CP.
Gene_expression (expression) of uPA
19) Confidence 0.10 Published 1997 Journal Gastroenterology Section Body Doc Link 9287983 Disease Relevance 0.10 Pain Relevance 0
RESULTS: Eight of 14 CP samples showed concomitant increased expression (P < 0.001) of uPA (5.2-fold), uPAR (5.9-fold), and TGF-beta 1 (8.8-fold) messenger RNA (mRNA) compared with normal controls.
Gene_expression (expression) of uPA
20) Confidence 0.09 Published 1997 Journal Gastroenterology Section Body Doc Link 9287983 Disease Relevance 0.08 Pain Relevance 0

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