INT71117

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 11
Disease Relevance 0.22
Pain Relevance 2.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plau) signal transduction (Plau) extracellular space (Plau)
extracellular region (Plau) kinase activity (Plau)
Plau (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 73 99.16 Very High Very High Very High
Morphine 9 99.06 Very High Very High Very High
Sciatic nerve 27 97.52 Very High Very High Very High
Dopamine 5 92.08 High High
Nucleus accumbens 7 85.60 High High
Eae 1 79.68 Quite High
Ventral tegmentum 5 78.64 Quite High
addiction 1 67.68 Quite High
Osteoarthritis 2 50.00 Quite Low
Chronic pancreatitis 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 2 81.92 Quite High
Osteoarthritis 2 71.84 Quite High
Temporomandibular Joint Syndrome 1 71.00 Quite High
Injury 18 26.76 Quite Low
Wound Healing 6 14.00 Low Low
Metastasis 6 5.00 Very Low Very Low Very Low
Apoptosis 6 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 6 5.00 Very Low Very Low Very Low
Brain Hemorrhage 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inhibition of this serine protease expression using doxycycline abolished the augmented acquisition produced by overexpression of uPA but not the expression of the cocaine-induced CPP.
Positive_regulation (overexpression) of Gene_expression (overexpression) of uPA associated with cocaine
1) Confidence 0.69 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.64
We show that overexpression of uPA in the Nac significantly augments cocaine-induced place preference.
Positive_regulation (overexpression) of Gene_expression (overexpression) of uPA associated with cocaine
2) Confidence 0.69 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.64
Our results suggest that that increased uPA expression with repeated drug exposure produces conditions for enhanced acquisition of cocaine-induced CPP, indicating that cocaine-induced CPP and reinstatement may be dependent on active extracellular uPA.
Positive_regulation (increased) of Gene_expression (expression) of uPA associated with cocaine
3) Confidence 0.69 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.41
Cocaine and many other psychostimulants strongly induce urokinase-type plasminogen activator (uPA) expression in the mesolimbic dopaminergic pathway, which plays a major role in drug-mediated behavioral plasticity [Bahi A, Boyer F, Gumy C, Kafri T, Dreyer JL.
Positive_regulation (induce) of Gene_expression (expression) of urokinase associated with cocaine
4) Confidence 0.50 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.24
Cocaine and many other psychostimulants strongly induce urokinase-type plasminogen activator (uPA) expression in the mesolimbic dopaminergic pathway, which plays a major role in drug-mediated behavioral plasticity [Bahi A, Boyer F, Gumy C, Kafri T, Dreyer JL.
Positive_regulation (induce) of Gene_expression (expression) of uPA associated with cocaine
5) Confidence 0.50 Published 2008 Journal Behav. Brain Res. Section Abstract Doc Link 18436315 Disease Relevance 0 Pain Relevance 0.24
The results showed that danshen increased the expressions of uPA, cyclin D1, E and ERK, JNK, and P38 MAP kinases via the FGF-2 signaling pathway in a dose-dependent manner.
Positive_regulation (increased) of Gene_expression (expressions) of uPA
6) Confidence 0.40 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
Danshen activated the FGF-signaling pathway as evidenced by increased levels of FGF-2 and uPA.
Positive_regulation (levels) of Gene_expression (levels) of uPA
7) Confidence 0.27 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
Danshen activated the FGF-signaling pathway as evidenced by increased levels of FGF-2 and uPA.
Positive_regulation (increased) of Gene_expression (levels) of uPA
8) Confidence 0.27 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2997511 Disease Relevance 0 Pain Relevance 0.05
RESULTS: The OA patients had significantly higher uPA activity and levels of uPA (median 80.01 ng/L), suPAR (median 7.54 ng/L), and PAI-1 (median 54.9 ng/mL) than the healthy control subjects (median 20.47 ng/L uPA, 2.34 ng/L suPAR, and 19.9 ng/mL PAI-1; (P < .05).
Positive_regulation (higher) of Gene_expression (activity) of uPA
9) Confidence 0.23 Published 2010 Journal Oral Surg Oral Med Oral Pathol Oral Radiol Endod Section Body Doc Link 20185343 Disease Relevance 0.14 Pain Relevance 0
In contrast, tPA-overexpressing animals when administered amphetamine or morphine showed greater place preference compared with uPA-overexpressing animals.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of uPA associated with morphine
10) Confidence 0.10 Published 2008 Journal Genes Brain Behav. Section Abstract Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.59
RESULTS: Eight of 14 CP samples showed concomitant increased expression (P < 0.001) of uPA (5.2-fold), uPAR (5.9-fold), and TGF-beta 1 (8.8-fold) messenger RNA (mRNA) compared with normal controls.
Positive_regulation (increased) of Gene_expression (expression) of uPA
11) Confidence 0.07 Published 1997 Journal Gastroenterology Section Body Doc Link 9287983 Disease Relevance 0.08 Pain Relevance 0

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