INT7114

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Context Info
Confidence 0.62
First Reported 1983
Last Reported 2011
Negated 52
Speculated 44
Reported most in Body
Documents 1192
Total Number 1237
Disease Relevance 290.76
Pain Relevance 755.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
synapses 66
spinal 51
hippocampus 40
spike 37
neurons 34
Ltp (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 44744 100.00 Very High Very High Very High
depression 9947 100.00 Very High Very High Very High
nMDA receptor 9761 100.00 Very High Very High Very High
Anterior cingulate cortex 8506 100.00 Very High Very High Very High
amygdala 7621 100.00 Very High Very High Very High
Pain 5345 100.00 Very High Very High Very High
c fibre 3692 100.00 Very High Very High Very High
agonist 1859 100.00 Very High Very High Very High
qutenza 1325 100.00 Very High Very High Very High
gABA 730 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 10029 100.00 Very High Very High Very High
Pain 7312 100.00 Very High Very High Very High
Anxiety Disorder 6545 100.00 Very High Very High Very High
Targeted Disruption 4722 100.00 Very High Very High Very High
Convulsion 710 100.00 Very High Very High Very High
Stress 2641 99.98 Very High Very High Very High
Li-fraumeni Syndrome 2523 99.98 Very High Very High Very High
Anaerobic Bacterial Infections 502 99.98 Very High Very High Very High
Amputation 160 99.98 Very High Very High Very High
Opiate Addiction 78 99.98 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The HFS paradigm has been chosen since theta burst stimulation did not produce consistent and reliable induction of LA-LTP.


Positive_regulation (induction) of LTP associated with long-term potentiation and amygdala
1) Confidence 0.62 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.35
Low-dose Xe in saline 0.9% blocked the induction of LTP.
Positive_regulation (induction) of LTP
2) Confidence 0.60 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17179253 Disease Relevance 0 Pain Relevance 0
High-dose Xe equilibrated in MC(R) 20% showed no additional effect when compared with the solvent, which blocked the induction of LTP.
Positive_regulation (induction) of LTP
3) Confidence 0.60 Published 2007 Journal Anesth. Analg. Section Body Doc Link 17179253 Disease Relevance 0 Pain Relevance 0
Comparison of the variance rates of C-fiber induced LTP of the field potential among the 3 groups showed that the variance rate of EA group was significantly lower than that of model group (P<0.01).
Positive_regulation (induced) of LTP
4) Confidence 0.60 Published 2009 Journal Zhen Ci Yan Jiu Section Body Doc Link 20128292 Disease Relevance 0.11 Pain Relevance 0
Thus, our study suggests that the MAPK signaling pathway is involved in the induction of cingulate LTP and plays a critical role in physiological conditions.



Positive_regulation (induction) of LTP associated with long-term potentiation
5) Confidence 0.59 Published 2007 Journal Mol Pain Section Abstract Doc Link PMC2245920 Disease Relevance 0.05 Pain Relevance 0.51
The induction of LTP was also blocked by 50 ?
Positive_regulation (induction) of LTP associated with long-term potentiation
6) Confidence 0.59 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.54
CONCLUSION: Kappa opioid receptor activation decreases synaptic transmission and inhibits the induction of LTP in the BLA of the mouse.
Positive_regulation (induction) of LTP in BLA
7) Confidence 0.57 Published 2009 Journal Eur J Pain Section Body Doc Link 18439862 Disease Relevance 0 Pain Relevance 0
The effect on synaptic transmission and on LTP was completely reversed or prevented by application of nor-BNI, which itself had no effect on synaptic transmission or the induction of LTP.
Positive_regulation (induction) of LTP
8) Confidence 0.57 Published 2009 Journal Eur J Pain Section Body Doc Link 18439862 Disease Relevance 0 Pain Relevance 0
U50,488H decreased synaptic transmission (baseline: 100+/-0.5%; U50,488H: 86.3+/-2.4%; n=6) and blocked the induction of LTP (U50,488H: 100+/-4.1%; HFS: 102.6+/-7%; n=6).
Positive_regulation (induction) of LTP
9) Confidence 0.57 Published 2009 Journal Eur J Pain Section Body Doc Link 18439862 Disease Relevance 0 Pain Relevance 0
Recent findings suggest that while ACC LTP in brain slice preparations is postsynaptically induced and expressed, injury triggered synaptic potentiation in the ACC contains both presynaptic enhancement of glutamate release and postsynaptic potentiation of AMPA receptor-mediated responses.
Positive_regulation (induced) of LTP in ACC associated with glutamate, injury, long-term potentiation and anterior cingulate cortex
10) Confidence 0.54 Published 2009 Journal Mol. Neurobiol. Section Abstract Doc Link 19821080 Disease Relevance 0.44 Pain Relevance 0.97
While the induction of LTP in general requires activation of postsynaptic glutamate receptors, the expression of LTP can be mediated by postsynaptic mechanisms and/or presynaptic enhancement of glutamate release.
Positive_regulation (induction) of LTP associated with glutamate, glutamate receptor and long-term potentiation
11) Confidence 0.54 Published 2009 Journal Mol. Neurobiol. Section Abstract Doc Link 19821080 Disease Relevance 0.40 Pain Relevance 0.83
Whereas basal transmission in the LA in horizontal slices is dependent on AMPA and kainate receptors [32]–[34], we could demonstrate that LTP induction in horizontal slices depends on NMDA receptors for both used inputs [32].
Positive_regulation (induction) of LTP associated with nmda receptor, long-term potentiation and amygdala
12) Confidence 0.54 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020947 Disease Relevance 0 Pain Relevance 0.96
The 129S6/SvEvTac mice have difficulties to induce and maintain LTP in the hippocampus.
Positive_regulation (induce) of LTP in hippocampus associated with hippocampus
13) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2409357 Disease Relevance 0.69 Pain Relevance 0.20
DBA/2, on the other hand, has a normal induction of LTP but their ability to maintain the LTP is impaired.
Positive_regulation (induction) of LTP
14) Confidence 0.54 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2409357 Disease Relevance 0.37 Pain Relevance 0.30
In the ACC, bath application of a NMDA receptor antagonist AP-5 completely abolished the induction of LTP induced by different induction protocols in the pyramidal cells [16], indicting that the induction of ACC LTP is completely dependent of postsynaptic activation of NMDA receptors.


Positive_regulation (induction) of LTP in pyramidal cells associated with nmda receptor antagonist, nmda receptor, pyramidal cell, long-term potentiation and anterior cingulate cortex
15) Confidence 0.51 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 0 Pain Relevance 1.21
Finally, in the prefrontal cortical (PFC) neurons including the ACC, LTP is induced by the pairing, spike-timing and theta burst protocols [16] as well as peripheral injury [17,6].
Positive_regulation (induced) of LTP in neurons associated with injury, long-term potentiation and anterior cingulate cortex
16) Confidence 0.51 Published 2009 Journal Mol Brain Section Body Doc Link PMC2644299 Disease Relevance 1.06 Pain Relevance 1.28
These results suggest that the activation of MAPK including ERK, JNK and p38, is critical for the induction of LTP in the ACC.


Positive_regulation (induction) of LTP associated with long-term potentiation and anterior cingulate cortex
17) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.39
Among them, activation of AC1 and CaMKIV have been reported to be essential for the induction of LTP in the ACC [4,9].
Positive_regulation (induction) of LTP associated with long-term potentiation and anterior cingulate cortex
18) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.57
We induced LTP by pairing 80 presynaptic pulses at 2 Hz with postsynaptic depolarization (holding at + 30 mV) [3,24].
Positive_regulation (induced) of LTP associated with long-term potentiation
19) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.61
M), in the intracellular solution had no effect on cingulate LTP induced by the pairing protocol (5 ?
Positive_regulation (induced) of LTP associated with long-term potentiation
20) Confidence 0.51 Published 2007 Journal Mol Pain Section Body Doc Link PMC2245920 Disease Relevance 0 Pain Relevance 0.53

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