INT71150

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Context Info
Confidence 0.46
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 13.67
Pain Relevance 14.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF) signal transduction (NGF) extracellular space (NGF)
extracellular region (NGF)
Anatomy Link Frequency
nerve 5
sensory neurons 2
Nociceptor 2
jaw 1
glial cell 1
NGF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 280 100.00 Very High Very High Very High
substance P 61 100.00 Very High Very High Very High
Neuropeptide 20 100.00 Very High Very High Very High
diabetic neuropathy 10 100.00 Very High Very High Very High
Catecholamine 17 99.98 Very High Very High Very High
Pain 251 99.60 Very High Very High Very High
nociceptor 43 99.54 Very High Very High Very High
antagonist 30 99.04 Very High Very High Very High
Lasting pain 51 98.08 Very High Very High Very High
Potency 2 96.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 48 100.00 Very High Very High Very High
Diabetic Neuropathy 9 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 6 99.76 Very High Very High Very High
Infection 3 99.60 Very High Very High Very High
Neuroma 6 99.10 Very High Very High Very High
Stress 71 98.84 Very High Very High Very High
Nociception 36 98.32 Very High Very High Very High
Endometriosis 448 98.08 Very High Very High Very High
Pain 302 98.08 Very High Very High Very High
Rheumatoid Arthritis 64 97.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thirty-seven different TRKA mutations, identified in patients in various countries, including nine frameshift, seven nonsense, seven splice, and 14 missense mutations, are distributed in an extracellular domain involved in NGF binding, as well as in the intracellular signal-transduction domain.
NGF Binding (binding) of associated with nerve growth factor
1) Confidence 0.46 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11748840 Disease Relevance 1.12 Pain Relevance 0.81
Nerve growth factor for the treatment of diabetic neuropathy: what went wrong, what went right, and what does the future hold?
Nerve growth factor Binding (went) of in Nerve associated with nerve growth factor and diabetic neuropathy
2) Confidence 0.37 Published 2002 Journal Int. Rev. Neurobiol. Section Title Doc Link 12198818 Disease Relevance 0.59 Pain Relevance 0.52
A phase II trial of nerve growth factor for sensory neuropathy associated with HIV infection.
nerve growth factor Binding (associated) of in nerve associated with pain, nerve growth factor, acquired immune deficiency syndrome or hiv infection, neuropathic pain and infection
3) Confidence 0.37 Published 2000 Journal Neurology Section Title Doc Link 10720278 Disease Relevance 0.40 Pain Relevance 0.20
Postnatally, the subpopulation of non-peptidergic nociceptors lose their ability to respond to NGF, start to express receptor element for and begin to respond to glial cell line-derived neurotrophic factor (GDNF).
NGF Binding (respond) of in glial cell associated with nerve growth factor and nociceptor
4) Confidence 0.36 Published 1999 Journal Pain Section Abstract Doc Link 10491977 Disease Relevance 0.41 Pain Relevance 1.16
As for unprocessed hproNGF, the binding of the R100 variants to p75NTR receptor shows only a limited impairment, showing that the impact of the R100 mutation on p75NTR receptor binding is greater in the context of mature, processed hNGF.
NGF Binding (binding) of
5) Confidence 0.36 Published 2010 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19945432 Disease Relevance 0.46 Pain Relevance 0.08
NGF, BDNF, Trk-A and Trk-B protein expression in the nondegenerate and degenerate human IVD
NGF Binding (degenerate) of associated with nerve growth factor
6) Confidence 0.36 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575613 Disease Relevance 0.13 Pain Relevance 0.25
Among these, nerve growth factor (NGF) and neurotrophin-3 (NT-3) are particularly important for sensory neurons.
NGF Binding (important) of in sensory neurons associated with nerve growth factor
7) Confidence 0.36 Published 1999 Journal J. Biomed. Sci. Section Abstract Doc Link 10087438 Disease Relevance 0.13 Pain Relevance 0.21
Among these, nerve growth factor (NGF) and neurotrophin-3 (NT-3) are particularly important for sensory neurons.
nerve growth factor Binding (important) of in sensory neurons associated with nerve growth factor
8) Confidence 0.36 Published 1999 Journal J. Biomed. Sci. Section Abstract Doc Link 10087438 Disease Relevance 0.13 Pain Relevance 0.21
Nociceptor mechanical threshold was assessed before and every 30 min for 3h after injection of human NGF (25 microg/ml, 10 microl, n=12), and in subsequent experiments NGF with TrkA (n=12) or P75 (n=11) receptor antibodies.
NGF Binding (injection) of in Nociceptor associated with nerve growth factor and nociceptor
9) Confidence 0.36 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.27 Pain Relevance 1.21
Furthermore, NGF sensitizes nerves [40], such that increased NGF expression in RA and OA may increase sensory nerve activity in the subchondral bone.
NGF Binding (sensitizes) of in sensory nerve associated with nerve growth factor and rheumatoid arthritis
10) Confidence 0.35 Published 2010 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2936950 Disease Relevance 0.82 Pain Relevance 0.62
Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor.
nerve growth factor Binding (receptor) of in nerve associated with nerve growth factor
11) Confidence 0.35 Published 1997 Journal Jpn. J. Hum. Genet. Section Title Doc Link 9290260 Disease Relevance 0.25 Pain Relevance 0.41
TRKA mutations are distributed in an extracellular domain involved in NGF binding, as well as in the intracellular signal-transduction domain.
NGF Binding (binding) of associated with nerve growth factor
12) Confidence 0.35 Published 2002 Journal Clin. Auton. Res. Section Abstract Doc Link 12102460 Disease Relevance 1.22 Pain Relevance 1.12
Immunhistochemistry of 10 traumatic human peripheral nerve neuromas and 5 normal digital nerves revealed a high immunoreactivity for the nerve growth factor (NGF) receptors p75 and trkA and the glial cell line-derived neurotrophic factor (GDNF) receptor GFRalpha-1.
NGF Binding (immunoreactivity) of in peripheral nerve associated with nerve growth factor and neuroma
13) Confidence 0.34 Published 2002 Journal Muscle Nerve Section Abstract Doc Link 11932982 Disease Relevance 0.33 Pain Relevance 0.05
Interactions of nerve growth factor (NGF) and its receptor tropomyosin-related kinase (trkA) appear to be critical for maintaining HSV latency.
nerve growth factor Binding (Interactions) of in nerve associated with cold sores and nerve growth factor
14) Confidence 0.33 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.40 Pain Relevance 0.22
Interactions of nerve growth factor (NGF) and its receptor tropomyosin-related kinase (trkA) appear to be critical for maintaining HSV latency.
NGF Binding (Interactions) of in nerve associated with cold sores and nerve growth factor
15) Confidence 0.33 Published 2008 Journal J. Neurovirol. Section Abstract Doc Link 19016376 Disease Relevance 0.40 Pain Relevance 0.23
Nociceptor mechanical threshold was assessed before and every 30 min for 3h after injection of human NGF (25 microg/ml, 10 microl, n=12), and in subsequent experiments NGF with TrkA (n=12) or P75 (n=11) receptor antibodies.
NGF Binding (injection) of in Nociceptor associated with nerve growth factor and nociceptor
16) Confidence 0.31 Published 2010 Journal Pain Section Abstract Doc Link 20064691 Disease Relevance 0.27 Pain Relevance 1.15
We describe an engineered mutein of hNGF, hNGF-61, that is selectively recognized, against endogenous NGF, by a specific antibody. hNGF-61 mutein has an identical potency and bioactivity profile as hNGF, in vitro and in vivo.
hNGF Binding (recognized) of associated with nerve growth factor and potency
17) Confidence 0.24 Published 2009 Journal Current Alzheimer research Section Abstract Doc Link 19355851 Disease Relevance 0.43 Pain Relevance 0.70
Besides the classical stress-related neurohormones—the players of the HPA axis and catecholamines—NGF and the neuropeptide SP are now recognized as pivotal mediators of the stress responses [131, 159–161].
NGF Binding (recognized) of associated with stress, nerve growth factor, catecholamine, neuropeptide and substance p
18) Confidence 0.24 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 1.53 Pain Relevance 1.26
Only a few small molecule NGF antagonists are available, but ALE0540, which inhibits the binding of NGF to TrkA and p75, and PD90780, which inhibits NGF binding to p75, have been proposed to have efficacy in chronic pain models [154,155].
NGF Binding (binding) of associated with nerve growth factor, lasting pain and antagonist
19) Confidence 0.20 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.10 Pain Relevance 1.38
Only a few small molecule NGF antagonists are available, but ALE0540, which inhibits the binding of NGF to TrkA and p75, and PD90780, which inhibits NGF binding to p75, have been proposed to have efficacy in chronic pain models [154,155].
NGF Binding (binding) of associated with nerve growth factor, lasting pain and antagonist
20) Confidence 0.19 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.10 Pain Relevance 1.42

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