INT71151

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 10
Total Number 11
Disease Relevance 6.65
Pain Relevance 6.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
nerve 3
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 33 100.00 Very High Very High Very High
Hsan 41 99.84 Very High Very High Very High
Locus ceruleus 9 99.70 Very High Very High Very High
Ventral tegmentum 6 99.28 Very High Very High Very High
opiate 5 98.52 Very High Very High Very High
withdrawal 6 97.72 Very High Very High Very High
Pain 1 95.16 Very High Very High Very High
Morphine 4 90.28 High High
antagonist 1 77.20 Quite High
addiction 1 62.36 Quite High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 176 100.00 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 41 99.84 Very High Very High Very High
Hypohidrosis 6 99.36 Very High Very High Very High
Pain 1 95.16 Very High Very High Very High
Cancer 70 94.72 High High
Carcinoid 2 94.44 High High
Small Cell Lung Cancer 2 93.96 High High
Lung Cancer 2 93.72 High High
Colon Cancer 2 90.88 High High
Apoptosis 4 88.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Point mutations affecting the NTRK1/TRKA gene, encoding one of the receptors for the nerve growth factor (NGF), have been detected in congenital insensitivity to pain with anhidrosis (CIPA), a human hereditary sensory neuropathy characterized by absence of reaction to noxious stimuli and anhidrosis.
Regulation (affecting) of NTRK1 in nerve associated with hypohidrosis, nerve growth factor and hsan
1) Confidence 0.62 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.52 Pain Relevance 0.57
In contrast to the substantial alterations observed in LC, there was no regulation of the neurotrophins or trk mRNAs within the VTA during chronic opiate treatment or withdrawal, with the exception of an increase in trkB mRNA at 6 hr of withdrawal.
Neg (no) Regulation (regulation) of trk associated with ventral tegmentum, locus ceruleus, opiate and withdrawal
2) Confidence 0.60 Published 1998 Journal J. Neurosci. Section Abstract Doc Link 9852605 Disease Relevance 0.06 Pain Relevance 1.60
Genetic defects in TRKA are responsible for a human disorder, congenital insensitivity to pain with anhidrosis (CIPA).
Regulation (responsible) of TRKA associated with hsan
3) Confidence 0.45 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.29 Pain Relevance 0.37
To define the defect of NTRK1 in CIPA patients, we have introduced one of the previously reported mutations (Gly571Arg) into both the NTRK1 and the TRK-T3 oncogene cDNAs.
Regulation (defect) of NTRK1 associated with hsan
4) Confidence 0.45 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.56 Pain Relevance 0.63
To define the defect of NTRK1 in CIPA patients, we have introduced one of the previously reported mutations (Gly571Arg) into both the NTRK1 and the TRK-T3 oncogene cDNAs.
Regulation (introduced) of TRK-T3 oncogene associated with hsan
5) Confidence 0.45 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.61 Pain Relevance 0.68
To define the defect of NTRK1 in CIPA patients, we have introduced one of the previously reported mutations (Gly571Arg) into both the NTRK1 and the TRK-T3 oncogene cDNAs.
Regulation (introduced) of NTRK1 associated with hsan
6) Confidence 0.45 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.61 Pain Relevance 0.68
These results will be useful for studies on the developmental and biological regulation of the TRKA gene and for further characterization of mutations in CIPA patients as well as elucidation of mechanisms responsible for rearrangement(s) observed in human tumors.
Regulation (regulation) of TRKA associated with cancer and hsan
7) Confidence 0.27 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.42 Pain Relevance 0.39
Human TRKA (NTRK1) encodes the receptor tyrosine kinases (RTKs) for nerve growth factor (NGF) and is the gene responsible for congenital insensitivity to pain with anhidrosis (CIPA), an autosomal recessive disorder characterized by a lack of pain sensation and anhidrosis.
Regulation (responsible) of TRKA in nerve associated with hypohidrosis, pain, nerve growth factor and hsan
8) Confidence 0.26 Published 2001 Journal Hum. Mol. Genet. Section Abstract Doc Link 11159935 Disease Relevance 0.62 Pain Relevance 0.73
Point mutations affecting the NTRK1/TRKA gene, encoding one of the receptors for the nerve growth factor (NGF), have been detected in congenital insensitivity to pain with anhidrosis (CIPA), a human hereditary sensory neuropathy characterized by absence of reaction to noxious stimuli and anhidrosis.
Regulation (affecting) of TRK in nerve associated with hypohidrosis, nerve growth factor and hsan
9) Confidence 0.26 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.53 Pain Relevance 0.57
In recent studies, we have shown that activation of doxycycline-inducible Notch1 in MTC cells significantly reduced MTC cellular growth and regulated calcitonin level in a dose-dependent fashion; furthermore, these changes were dependent on the amount of Notch1 protein [35].
Regulation (regulated) of MTC associated with thyroid neoplasm
10) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 1.77 Pain Relevance 0
Likewise, targeting angiogenesis in MTC with small-molecule VEGF inhibitors and multitarget kinase inhibitors is currently under investigation and has demonstrated promising results.
Regulation (targeting) of MTC associated with thyroid neoplasm
11) Confidence 0.05 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.66 Pain Relevance 0

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