INT71152

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 10.28
Pain Relevance 5.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (NTRK1) endosome (NTRK1) plasma membrane (NTRK1)
Anatomy Link Frequency
nerve 2
thyroid 1
neurons 1
osteoblasts 1
platelet 1
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 34 100.00 Very High Very High Very High
Hsan 38 99.82 Very High Very High Very High
Congenital analgesia 1 98.64 Very High Very High Very High
Action potential 1 97.28 Very High Very High Very High
Pain 9 97.00 Very High Very High Very High
Inflammation 4 95.08 Very High Very High Very High
nociceptor 11 91.52 High High
Facet joint 4 81.52 Quite High
Glutamate receptor 3 75.00 Quite High
Lasting pain 2 74.80 Quite High
Disease Link Frequency Relevance Heat
Thyroid Neoplasm 178 100.00 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 38 99.82 Very High Very High Very High
Apoptosis 21 99.64 Very High Very High Very High
Cancer 73 99.16 Very High Very High Very High
Herpes Simplex Virus 1 99.16 Very High Very High Very High
Uniparental Disomy 4 99.06 Very High Very High Very High
Congenital Pain Insensitivity 1 98.64 Very High Very High Very High
Disease 24 98.62 Very High Very High Very High
Cold Sores 4 98.28 Very High Very High Very High
Reprotox - General 1 12 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Deregulation of NTRK1 activity is associated with several human disorders.
Negative_regulation (Deregulation) of NTRK1
1) Confidence 0.59 Published 2006 Journal Cancer Lett. Section Abstract Doc Link 16242838 Disease Relevance 0.55 Pain Relevance 0.09
Genetic defects in TRKA are responsible for a human disorder, congenital insensitivity to pain with anhidrosis (CIPA).
Negative_regulation (defects) of TRKA associated with hsan
2) Confidence 0.43 Published 1997 Journal Jpn. J. Hum. Genet. Section Abstract Doc Link 9290260 Disease Relevance 0.29 Pain Relevance 0.36
Our results demonstrate clearly that the CIPA mutations cause the inactivation of the NTRK1 receptor, thus exerting a loss of function effect, and provide an experimental approach to distinguish functional mutations from genetic polymorphisms.
Negative_regulation (inactivation) of NTRK1 receptor associated with hsan
3) Confidence 0.43 Published 2000 Journal J. Cell. Physiol. Section Abstract Doc Link 10567924 Disease Relevance 0.53 Pain Relevance 0.60
The Gly571Arg mutation, associated with the autonomic and sensory disorder congenital insensitivity to pain with anhidrosis, causes the inactivation of the NTRK1/nerve growth factor receptor.
Negative_regulation (inactivation) of NTRK1 in nerve associated with nerve growth factor and hsan
4) Confidence 0.43 Published 2000 Journal J. Cell. Physiol. Section Title Doc Link 10567924 Disease Relevance 0.61 Pain Relevance 0.70
A paternal uniparental disomy for chromosome 1 is likely to be the cause of reduction to homozygosity of the TRKA gene mutation in this family.
Negative_regulation (reduction) of TRKA associated with uniparental disomy
5) Confidence 0.42 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11668614 Disease Relevance 0.96 Pain Relevance 0.57
In fact, receptor rearrangements or point mutations convert RET and NTRK1 in dominantly acting transforming genes leading to thyroid tumors, whereas inactivating mutations, associated with Hirschsprung's disease (HSCR) and congenital insensitivity to pain with anhidrosis (CIPA), impair RET and NTRK1 functions, respectively.
Negative_regulation (impair) of NTRK1 in thyroid associated with thyroid neoplasm, disease and hsan
6) Confidence 0.42 Published 2003 Journal J. Cell. Physiol. Section Abstract Doc Link 12652644 Disease Relevance 0.68 Pain Relevance 0.10
CEP-2563 dihydrochloride (CEP-2563) is a soluble lysinyl-beta-alanyl ester of CEP-751, a potent inhibitor of the trk family of receptor tyrosine kinases and the platelet-derived growth factor (PDGF) receptor tyrosine kinase.
Negative_regulation (inhibitor) of trk in platelet
7) Confidence 0.41 Published 2004 Journal Invest New Drugs Section Abstract Doc Link 15292715 Disease Relevance 0.35 Pain Relevance 0
All these data further support findings that TRKA defects can cause CIPA in various ethnic groups.
Negative_regulation (defects) of TRKA associated with hsan
8) Confidence 0.37 Published 2001 Journal Hum. Mutat. Section Abstract Doc Link 11668614 Disease Relevance 0.70 Pain Relevance 0.46
Humans deficient of trkA suffer from the rare disorder of congenital analgesia.
Negative_regulation (deficient) of trkA associated with congenital analgesia
9) Confidence 0.37 Published 1999 Journal Pain Section Abstract Doc Link 10491977 Disease Relevance 0.32 Pain Relevance 0.97
The other putative mutant D668Y might be a rare polymorphism or might impair the function of TRKA without compromising autophosphorylation.
Spec (might) Negative_regulation (impair) of TRKA
10) Confidence 0.36 Published 2001 Journal Hum. Mol. Genet. Section Abstract Doc Link 11159935 Disease Relevance 0.45 Pain Relevance 0.61
Zhangfei, a novel regulator of the human nerve growth factor receptor, trkA.
Negative_regulation (regulator) of trkA in nerve associated with nerve growth factor
11) Confidence 0.35 Published 2008 Journal J. Neurovirol. Section Title Doc Link 19016376 Disease Relevance 0.42 Pain Relevance 0.21
This indicates a possible therapeutic area for the antibodies that could block the NGF/TrkA system, in order to modulate the frequency and the duration of the action potential of nociceptive neurons during chronic inflammation.
Negative_regulation (block) of TrkA in neurons associated with nociception, action potential and inflammation
12) Confidence 0.28 Published 2009 Journal Eur Spine J Section Abstract Doc Link 19399531 Disease Relevance 0.61 Pain Relevance 0.51
Similarly, using microdissection and genotyping, Sheikh et al. studied 11 cases of MTC for allelic losses in a panel of known tumor suppressor genes in an attempt to elucidate the molecular basis for clinical outcome.
Negative_regulation (losses) of MTC associated with thyroid neoplasm and cancer
13) Confidence 0.09 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.94 Pain Relevance 0
More importantly, ectopic raf-1 expression led to significant MTC growth suppression both in vitro and in a mouse xenograft model of MTC [40–43].
Negative_regulation (suppression) of MTC associated with thyroid neoplasm
14) Confidence 0.09 Published 2009 Journal Journal of Oncology Section Body Doc Link PMC2798103 Disease Relevance 0.99 Pain Relevance 0
The indocarbazole compounds, CEP-701 and CEP-751, are potent inhibitor of this Trk receptor survival signaling and thus selectively induces apoptosis of prostate cancer cells in various in vitro and in vivo models.
Negative_regulation (inhibitor) of Trk receptor associated with apoptosis and reprotox - general 1
15) Confidence 0.05 Published 2002 Journal Cancer Res. Section Abstract Doc Link 11861369 Disease Relevance 1.00 Pain Relevance 0.07
Trk receptor inhibition induces apoptosis of proliferating but not quiescent human osteoblasts.
Negative_regulation (inhibition) of Trk receptor in osteoblasts associated with apoptosis
16) Confidence 0.05 Published 2002 Journal Cancer Res. Section Title Doc Link 11861369 Disease Relevance 0.89 Pain Relevance 0.09
K252a, a specific tyrosine kinase (Trk) inhibitor, completely suppresses BDNF- and NT-4/5-enhanced BDNF mRNA expression.
Negative_regulation (inhibitor) of Trk
17) Confidence 0.02 Published 2002 Journal Neuropharmacology Section Abstract Doc Link 12069900 Disease Relevance 0 Pain Relevance 0.13

General Comments

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