INT71155

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Context Info
Confidence 0.15
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 7
Disease Relevance 3.76
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PLEK) extracellular region (PLEK) cytoplasm (PLEK)
Anatomy Mention Frequency
platelet 7
PLEK (Homo sapiens)
fga (Xenopus laevis)
Pain Term Frequency Confidence Heat
antagonist 3 99.92 Very High Very High Very High
ischemia 9 99.52 Very High Very High Very High
depression 1 98.04 Very High Very High Very High
Angina 16 97.76 Very High Very High Very High
aspirin 6 96.08 Very High Very High Very High
Clonidine 4 85.88 High High
agonist 4 75.00 Quite High
Catecholamine 2 72.04 Quite High
Percutaneous transluminal coronary angioplasty 5 37.44 Quite Low
beta blocker 7 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Cv Unclassified Under Development 7 99.52 Very High Very High Very High
Depression 1 98.04 Very High Very High Very High
Cv General 3 Under Development 16 97.76 Very High Very High Very High
Syndrome 7 96.96 Very High Very High Very High
Myocardial Infarction 19 95.40 Very High Very High Very High
Coronary Artery Disease 21 95.00 High High
Genetic Predisposition To Disease 1 93.72 High High
Atherosclerotic Plaque 2 91.08 High High
Acute Coronary Syndrome 6 90.60 High High
Thrombosis 3 89.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Therefore, we conclude that strenuous, acute exercise enhances platelet activation, possibly by altering the performance of platelet alpha2-adrenergic receptors, facilitating the ability of ADP-activated fibrinogen receptors, and enhancing fibrinogen binding to platelet fibrinogen receptors.
platelet Binding (binding) of fibrinogen in platelet
1) Confidence 0.15 Published 1999 Journal Arterioscler. Thromb. Vasc. Biol. Section Abstract Doc Link 10364090 Disease Relevance 0 Pain Relevance 0.42
Glycoprotein (GP) IIb/IIIa inhibitors block the final common pathway of platelet aggregation by preventing fibrinogen from binding to the GP IIb/IIIa platelet receptor.
platelet Binding (binding) of fibrinogen in platelet
2) Confidence 0.06 Published 2000 Journal J. Thromb. Thrombolysis Section Abstract Doc Link 10947917 Disease Relevance 0.92 Pain Relevance 0.38
Modulation of platelet-neutrophil interaction with pharmacological inhibition of fibrinogen binding to platelet GPIIb/IIIa receptor.
platelet Binding (binding) of fibrinogen in platelet
3) Confidence 0.04 Published 1999 Journal Thromb. Haemost. Section Title Doc Link 10064007 Disease Relevance 0.27 Pain Relevance 0.15
We studied the ischemia-induced alterations in fibrinogen binding to activated platelet GP IIb/IIIa receptors and CD 62p expression.
platelet Binding (binding) of fibrinogen in platelet associated with ischemia
4) Confidence 0.04 Published 1999 Journal Thromb. Res. Section Abstract Doc Link 9950258 Disease Relevance 0.86 Pain Relevance 0.24
Recently, antagonists to platelet glycoprotein IIb/IIIa (GPIIb/IIIa), a platelet surface integrin whose activation and subsequent binding to fibrinogen is the final common step in the formation of platelet aggregates, have been utilised to treat unstable angina and myocardial infarction.
platelet Binding (binding) of fibrinogen in platelet associated with angina, antagonist and myocardial infarction
5) Confidence 0.02 Published 1997 Journal Expert Opin Investig Drugs Section Abstract Doc Link 15991900 Disease Relevance 0.52 Pain Relevance 0.33
The final common pathway to platelet aggregation is the activation of the platelet glycoprotein (GP) IIb-IIIa receptor, which allows the cross-linking of adjacent platelets by the adhesive plasma proteins fibrinogen and von Willebrand's factor.
platelet Binding (cross-linking) of fibrinogen in platelet
6) Confidence 0.02 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9291240 Disease Relevance 0.81 Pain Relevance 0.16
The glycoprotein IIb/IIIa (GPIIb/IIIa) is a platelet membrane receptor for fibrinogen and von Willebrand factor.
platelet Binding (receptor) of fibrinogen in platelet
7) Confidence 0.01 Published 2007 Journal Thromb J Section Body Doc Link PMC2200636 Disease Relevance 0.37 Pain Relevance 0

General Comments

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