INT71161

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Context Info
Confidence 0.26
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 3.59
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ITGB3) plasma membrane (ITGB3)
Anatomy Link Frequency
platelet 3
tube 1
leucocyte 1
ITGB3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Delta-9-tetrahydrocannabinol 18 99.70 Very High Very High Very High
Angina 2 99.48 Very High Very High Very High
Cannabinoid receptor 8 98.44 Very High Very High Very High
Cannabinoid 2 91.36 High High
Lasting pain 2 79.56 Quite High
Onset of action 1 58.88 Quite High
Arthritis 121 50.00 Quite Low
abdominal pain 1 31.64 Quite Low
Inflammation 14 26.32 Quite Low
rheumatoid arthritis 85 18.08 Low Low
Disease Link Frequency Relevance Heat
Cv General 3 Under Development 8 99.84 Very High Very High Very High
Apoptosis 16 99.16 Very High Very High Very High
Cancer 192 97.40 Very High Very High Very High
Adhesions 11 95.00 High High
Myocardial Infarction 3 94.28 High High
Glioma 3 89.76 High High
Hemorrhage 9 89.52 High High
Disease 38 88.12 High High
Thromboangitis Obliterans 2 84.16 Quite High
Thrombosis Related Under Development 2 79.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
3 (CD51/CD61, integrin expressed on endothelial cells, fibroblasts, osteoclasts, etc., clone LM609; Chemicon), anti-E-selectin (CD62E, endothelial leucocyte adhesion molecule 1, clone 1.2B6), anti-ICAM-1 (CD54, intercellular adhesion molecule [ICAM]-1, clone 6.5B5), anti-VCAM-1 (CD106, vascular cell adhesion molecule [VCAM]-1, clone 1.4C3), the rabbit polyclonal anti-L-citrulline antibody (citrullinated peptides; Biogenesis, Poole, UK), and Mab-12A (detecting major histocompatibility complex [MHC] class II–human cartilage [HC] gp39 peptide complexes; NV Organon, Oss, The Netherlands) [18,21].
Gene_expression (expressed) of CD61 in leucocyte associated with adhesions
1) Confidence 0.26 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1174942 Disease Relevance 0.28 Pain Relevance 0
THC increased the expression of glycoprotein IIb-IIIa and P selectin on human platelets in a concentration-dependent manner.
Gene_expression (expression) of glycoprotein IIb-IIIa in platelets associated with delta-9-tetrahydrocannabinol
2) Confidence 0.21 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385362 Disease Relevance 0.49 Pain Relevance 0.62
The effects of THC (final concentrations 10(-7) to 10(-5) M) on the expression of activated platelet fibrinogen receptor (glycoprotein IIb-IIIa) and P selectin were characterized by flow cytometry.
Gene_expression (expression) of glycoprotein IIb-IIIa in platelet associated with delta-9-tetrahydrocannabinol
3) Confidence 0.16 Published 2004 Journal Anesth. Analg. Section Abstract Doc Link 15385362 Disease Relevance 0.57 Pain Relevance 0.60
Higher doses of eptifibatide were therefore selected for the Platelet GP IIb-IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy (PURSUIT) trial, which enrolled patients with unstable angina or non-Q-wave myocardial infarction.
Gene_expression (selected) of Platelet GP IIb-IIIa in Platelet associated with angina, myocardial infarction and cv general 3 under development
4) Confidence 0.11 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9291241 Disease Relevance 0.65 Pain Relevance 0.22
They were found CD45 negative (Fig. 3) and also CD61, CD62, CD71 and CD235a negative.
Neg (negative) Gene_expression (negative) of CD61
5) Confidence 0.04 Published 2010 Journal Clin Exp Metastasis Section Body Doc Link PMC2910884 Disease Relevance 0.81 Pain Relevance 0
Expression of antisense to integrin subunit beta 3 inhibits microvascular EC capillary tube formation in fibrin, with the extent of down-regulation correlating with the extent of tube formation inhibition [121].


Gene_expression (Expression) of integrin subunit beta 3 in tube
6) Confidence 0.03 Published 2004 Journal J Transl Med Section Body Doc Link PMC455695 Disease Relevance 0.79 Pain Relevance 0

General Comments

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