INT71173

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 3.17
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
Anatomy Link Frequency
chondrocytes 2
neuronal 2
spleen 2
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2 100.00 Very High Very High Very High
Morphine 5 99.62 Very High Very High Very High
Analgesic 1 99.00 Very High Very High Very High
Inflammation 10 98.72 Very High Very High Very High
cINOD 6 92.96 High High
chemokine 2 91.72 High High
Pain 2 91.68 High High
aspirin 9 84.64 Quite High
adenocard 3 77.96 Quite High
Osteoarthritis 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 11 100.00 Very High Very High Very High
INFLAMMATION 13 98.72 Very High Very High Very High
Pain 2 91.68 High High
Stress 1 87.92 High High
Hypertension 2 80.88 Quite High
Rupture 2 79.68 Quite High
Pressure And Volume Under Development 2 79.52 Quite High
Infarction 1 78.72 Quite High
Atherosclerosis 4 75.00 Quite High
Osteoarthritis 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Western blot analysis of sensitive and resistant LDC clonal lines confirmed increases in cyclin D1, STAT6, Bcl-xL, and BAD, with decreased expression of caspase 1.
Negative_regulation (decreased) of Gene_expression (expression) of caspase 1
1) Confidence 0.36 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.10 Pain Relevance 0.07
The anti-inflammatory and analgesic effects of COX inhibition are reinforced through inhibition of caspase-1 regulated cytokine production, while nitric oxide donation provides multiorgan protection.
Negative_regulation (inhibition) of Gene_expression (production) of caspase-1 associated with inflammation, analgesic and cytokine
2) Confidence 0.34 Published 2006 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 16611049 Disease Relevance 0.73 Pain Relevance 0.66
Furthermore, we observed that resveratrol as well as ALLN inhibited IL-1beta-induced apoptosis, caspase-3 activation and PARP cleavage in human articular chondrocytes.
Negative_regulation (inhibited) of Gene_expression (apoptosis) of IL-1beta-induced in chondrocytes associated with apoptosis
3) Confidence 0.08 Published 2008 Journal Biochem. Pharmacol. Section Abstract Doc Link 18606398 Disease Relevance 0.87 Pain Relevance 0.29
Rather, ascorbic acid dose-dependently (0.1-100 microM) produced a significant reduction in IL-1beta-mediated production of 8-iso-prostaglandin F2alpha (8-iso-PGF2alpha), a reliable indicator of free radical formation, suggesting that the effects of ascorbic acid on COX-2-mediated PGE2 biosynthesis may be the result of the maintenance of the neuronal redox status since COX activity is known to be enhanced by oxidative stress.
Spec (suggesting) Negative_regulation (reduction) of Gene_expression (production) of IL-1beta-mediated in neuronal associated with stress
4) Confidence 0.06 Published 2006 Journal J. Neuroimmunol. Section Abstract Doc Link 16529823 Disease Relevance 0.28 Pain Relevance 0.21
Prostaglandin E2, known as an activator of the prostanoid receptors EP2 and EP4, which are positively coupled to adenylyl cyclase, also decreased the IL-1beta-induced eotaxin and MCP-1 production by 57+/-17 and 53+/-4%, respectively.
Negative_regulation (decreased) of Gene_expression (production) of IL-1beta-induced
5) Confidence 0.03 Published 2003 Journal Eur. Respir. J. Section Abstract Doc Link 12952251 Disease Relevance 0.19 Pain Relevance 0.22
Chronic exposure to morphine, but not ethanol, attenuates the expression of interleukin-1 beta converting enzyme in rat spleen.
Negative_regulation (attenuates) of Gene_expression (expression) of converting enzyme in spleen associated with morphine
6) Confidence 0.02 Published 1997 Journal Immunol. Lett. Section Title Doc Link 9293396 Disease Relevance 0 Pain Relevance 0.40

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