INT71174

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 0
Speculated 5
Reported most in Abstract
Documents 44
Total Number 49
Disease Relevance 30.30
Pain Relevance 9.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CASP1) peptidase activity (CASP1) signal transduction (CASP1)
intracellular (CASP1) cytoplasm (CASP1)
Anatomy Link Frequency
chondrocyte 2
spleen 2
acinar cells 2
plaques 2
macrophages 1
CASP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 98 100.00 Very High Very High Very High
addiction 17 100.00 Very High Very High Very High
Gabapentin 4 100.00 Very High Very High Very High
antagonist 87 99.92 Very High Very High Very High
Chronic pancreatitis 59 99.92 Very High Very High Very High
agonist 65 99.60 Very High Very High Very High
Morphine 19 99.32 Very High Very High Very High
Inflammation 192 98.96 Very High Very High Very High
Analgesic 10 98.72 Very High Very High Very High
fibrosis 79 96.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Apoptosis 186 100.00 Very High Very High Very High
Pancreatic Cancer 39 100.00 Very High Very High Very High
Adhesions 2 100.00 Very High Very High Very High
Death 94 99.92 Very High Very High Very High
Pancreatitis 74 99.92 Very High Very High Very High
Disease 136 99.88 Very High Very High Very High
Cancer 53 99.84 Very High Very High Very High
Hyperplasia 28 99.12 Very High Very High Very High
INFLAMMATION 221 98.96 Very High Very High Very High
Atherosclerotic Plaque 4 97.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We also investigated crucial steps in the apoptotic process, including Fas/Fas ligand (FasL) phenotype, intracellular expression of the interleukin-1beta-converting enzyme (ICE) p20, mitochondrial membrane potential (DeltaPsim), generation of mitochondrial reactive oxygen species, and glutathione (GSH) levels.
Gene_expression (expression) of ICE
1) Confidence 0.75 Published 2003 Journal Acta Anaesthesiol Scand Section Body Doc Link 12969109 Disease Relevance 0.16 Pain Relevance 0
In conclusion, the expression of caspase-1 is a frequent event in chronic pancreatitis and its distribution pattern may reflect two functions of this protease: on one hand its participation in the apoptotic pathway in atrophic acinar cells and, on the other hand, its role in proliferation and differentiation in proliferating duct cells.
Gene_expression (expression) of caspase-1 in duct associated with apoptosis and chronic pancreatitis
2) Confidence 0.74 Published 2001 Journal Pancreas Section Abstract Doc Link 11345139 Disease Relevance 0.83 Pain Relevance 0.41
Interestingly, we found expression of caspase-1 in three distinct morphologic compartments: (i) in atrophic acinar cells (31 of 35; 89%), (ii) proliferating cells of ductal origin (33 of 38; 87%), and (iii) in acinar cells redifferentiating to form tubular structures (26 of 31; 83%).
Gene_expression (expression) of caspase-1 in acinar cells
3) Confidence 0.74 Published 2001 Journal Pancreas Section Abstract Doc Link 11345139 Disease Relevance 0.79 Pain Relevance 0.37
We found a clear expression of caspase-1 in chronic pancreatitis, but not in normal pancreatic tissues.
Spec (clear) Gene_expression (expression) of caspase-1 associated with chronic pancreatitis
4) Confidence 0.74 Published 2001 Journal Pancreas Section Abstract Doc Link 11345139 Disease Relevance 0.75 Pain Relevance 0.32
No correlation was found between any of the examined clinicopathologic features and the caspase-1 expression in chronic pancreatitis.
Gene_expression (expression) of caspase-1 associated with chronic pancreatitis
5) Confidence 0.74 Published 2001 Journal Pancreas Section Abstract Doc Link 11345139 Disease Relevance 0.75 Pain Relevance 0.41
We investigated the expression of caspase-1 in 38 chronic pancreatitis tissues, six pancreatitis tissues from patients with pancreatic carcinoma and nine normal pancreatic tissues by immunohistochemistry.
Spec (investigated) Gene_expression (expression) of caspase-1 associated with pancreatic cancer, pancreatitis and chronic pancreatitis
6) Confidence 0.74 Published 2001 Journal Pancreas Section Abstract Doc Link 11345139 Disease Relevance 0.72 Pain Relevance 0.25
Overexpression of caspase-1 (interleukin-1beta converting enzyme) in chronic pancreatitis and its participation in apoptosis and proliferation.
Gene_expression (Overexpression) of caspase-1 associated with apoptosis and chronic pancreatitis
7) Confidence 0.74 Published 2001 Journal Pancreas Section Title Doc Link 11345139 Disease Relevance 0.67 Pain Relevance 0.25
These immunohistochemical findings were confirmed by Western blot analysis, which showed an expression of caspase-1 in 85% of the tissues.
Gene_expression (expression) of caspase-1
8) Confidence 0.74 Published 2001 Journal Pancreas Section Abstract Doc Link 11345139 Disease Relevance 0.76 Pain Relevance 0.40
as the principal consequence of CIAS1 mutations leading to the manifestation of the clinical disease, the CASP1 mutation appears to exert its pro-inflammatory effect by engaging RIP2, resulting in excessive activation of NF-?
Gene_expression (mutation) of CASP1 associated with inflammation and disease
9) Confidence 0.61 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 1.11 Pain Relevance 0.14
It has been proposed that these mutations have a gain of function effect, leading to spontaneous oligorimerization of NALP3 subunits around mutated NACHT domains and subsequent caspase-1 activation resulting in an excessive and inappropriate IL-1?
Gene_expression (activation) of caspase-1
10) Confidence 0.61 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727888 Disease Relevance 0.63 Pain Relevance 0
Gene expression analysis showed that the proapoptotic genes (ie, BAX, CASP1, FAS, FAS L, FOS, NFkB2, P53, PCNA) were significantly more expressed (P<0.001) in ACS plaques, whereas the antiapoptotic genes (ie, MDM2, TERT, XRCC1) were more transcribed (P<0.001) in stable angina plaques.
Gene_expression (expressed) of CASP1 in plaques
11) Confidence 0.57 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.14 Pain Relevance 0
METHODS AND RESULTS: We analyzed the expression of apoptotic genes such as BAX, CASP1, FAS, FAS L, FOS, MDM2, NFkB2, P53, PCNA, TERT, and XRCC1 in coronary plaques collected with directional coronary atherectomy from 15 patients with stable angina and 15 with acute coronary syndromes without ST elevation (ACS).
Spec (analyzed) Gene_expression (expression) of CASP1 in plaques
12) Confidence 0.57 Published 2004 Journal Circulation Section Body Doc Link 15364800 Disease Relevance 0.19 Pain Relevance 0
Using Affymetrix GeneChip (HG-U133A), we have selected a subset of 692 differentially expressed genes, several of which are-cullin 4A (CUL4A), ubiquitin carrier protein (E2-EPF), proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) (PSMB8), protein tyrosine phosphatase type IVA (PTP4A1), intercellular adhesion molecule 1 (ICAM1), prostaglandin-endoperoxide synthase 2 (PTGS2), and caspase 1 (CASP1).
Gene_expression (expressed) of caspase 1 associated with adhesions
13) Confidence 0.56 Published 2004 Journal Toxicon Section Abstract Doc Link 15501285 Disease Relevance 0.84 Pain Relevance 0.75
Using Affymetrix GeneChip (HG-U133A), we have selected a subset of 692 differentially expressed genes, several of which are-cullin 4A (CUL4A), ubiquitin carrier protein (E2-EPF), proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional protease 7) (PSMB8), protein tyrosine phosphatase type IVA (PTP4A1), intercellular adhesion molecule 1 (ICAM1), prostaglandin-endoperoxide synthase 2 (PTGS2), and caspase 1 (CASP1).
Gene_expression (expressed) of CASP1 associated with adhesions
14) Confidence 0.56 Published 2004 Journal Toxicon Section Abstract Doc Link 15501285 Disease Relevance 0.84 Pain Relevance 0.75
The anti-inflammatory and analgesic effects of COX inhibition are reinforced through inhibition of caspase-1 regulated cytokine production, while nitric oxide donation provides multiorgan protection.
Gene_expression (production) of caspase-1 associated with inflammation, analgesic and cytokine
15) Confidence 0.53 Published 2006 Journal Cardiovascular & hematological agents in medicinal chemistry Section Abstract Doc Link 16611049 Disease Relevance 0.73 Pain Relevance 0.66
The STAT proteins have been implicated in resistance to apoptosis, potentially via their ability to modulate caspase 1 (ICE), Bcl-xL, and cyclin D1 expression.
Gene_expression (expression) of caspase 1 associated with apoptosis
16) Confidence 0.48 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.13 Pain Relevance 0.05
Western blot analysis of sensitive and resistant LDC clonal lines confirmed increases in cyclin D1, STAT6, Bcl-xL, and BAD, with decreased expression of caspase 1.
Gene_expression (expression) of caspase 1
17) Confidence 0.48 Published 2005 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 16005468 Disease Relevance 1.09 Pain Relevance 0.07
Importantly, in degenerate IVDs there is a significant increase in IL-1RI-immunopositive chondrocyte-like cells by comparison with non-degenerate IVDs, indicating an increased responsiveness to IL-1; and there are increased numbers of chondrocyte-like cells expressing ICE, an enzyme required to convert the inactive pro-IL-1?
Gene_expression (expressing) of ICE in chondrocyte
18) Confidence 0.45 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.26 Pain Relevance 0.06
The overexpression of caspase-1 may lead to programmed cell death [25].
Gene_expression (overexpression) of caspase-1 associated with apoptosis
19) Confidence 0.42 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0.66 Pain Relevance 0
When coupled with an increase in IL-1 receptor and ICE with increasing degeneration, the net effect would be the initiation and perpetuation of an IL-1-mediated response.
Gene_expression (receptor) of ICE
20) Confidence 0.39 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175026 Disease Relevance 0.23 Pain Relevance 0.08

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