INT71176

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Context Info
Confidence 0.21
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 4.93
Pain Relevance 1.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (ICAM1, ITGB2) plasma membrane (ICAM1, ITGB2) extracellular space (ICAM1)
cell-cell signaling (ITGB2)
Anatomy Link Frequency
monocyte 2
epithelial cells 2
endothelial cells 1
ICAM1 (Homo sapiens)
ITGB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 20 82.12 Quite High
Angina 14 78.00 Quite High
psoriasis 144 74.20 Quite High
cytokine 20 56.00 Quite High
Arthritis 18 51.40 Quite High
Adalimumab 4 45.40 Quite Low
rheumatoid arthritis 14 41.76 Quite Low
Inflammation 95 36.44 Quite Low
Etanercept 74 35.88 Quite Low
Inflammatory response 14 28.12 Quite Low
Disease Link Frequency Relevance Heat
Adhesions 196 100.00 Very High Very High Very High
Nicotine Addiction 366 98.80 Very High Very High Very High
Myocardial Infarction 12 84.40 Quite High
Cv General 3 Under Development 12 78.00 Quite High
Psoriasis 184 74.20 Quite High
Increased Venous Pressure Under Development 32 73.12 Quite High
Disease 76 62.92 Quite High
Seronegative Spondarthritis 16 51.40 Quite High
Rheumatoid Arthritis 14 41.76 Quite Low
INFLAMMATION 109 36.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This indicates that smoking may lead to increased monocyte-HUVEC adhesion by influencing an endothelial Mac-1 ligand, with ICAM-1 the prime candidate, or that smoking may induce conformational, or other, alterations to Mac-1, leading to increased affinity for ICAM-1.
ICAM-1 Binding (ligand) of Mac-1 in monocyte associated with nicotine addiction and adhesions
1) Confidence 0.21 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2669563 Disease Relevance 1.18 Pain Relevance 0.08
This indicates that smoking may lead to increased monocyte-HUVEC adhesion by influencing an endothelial Mac-1 ligand, with ICAM-1 the prime candidate, or that smoking may induce conformational, or other, alterations to Mac-1, leading to increased affinity for ICAM-1.
ICAM-1 Binding (ligand) of Mac-1 in monocyte associated with nicotine addiction and adhesions
2) Confidence 0.21 Published 2003 Journal Tob Induc Dis Section Body Doc Link PMC2671531 Disease Relevance 1.18 Pain Relevance 0.08
The LFA-1 integrin binds to the cognate ligand, the intercellular adhesion molecule (ICAM)-1, expressed on the surface of the endothelial and epithelial cells as well as on antigen-presenting cells.
ICAM Binding (binds) of LFA-1 in epithelial cells associated with adhesions
3) Confidence 0.12 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.68 Pain Relevance 0.22
Intercellular adhesion molecule-1 (ICAM-1) is a major ligand for 2 members of the CD18 family of leukocyte integrin adhesion molecules and mediates adhesion between leukocytes and stimulated endothelial cells.
adhesion molecule-1 Binding (ligand) of CD18 in endothelial cells associated with adhesions
4) Confidence 0.07 Published 1997 Journal Jpn. Circ. J. Section Abstract Doc Link 9293403 Disease Relevance 1.20 Pain Relevance 0.47
The LFA-1 integrin binds to the cognate ligand, the intercellular adhesion molecule (ICAM)-1, expressed on the surface of the endothelial and epithelial cells as well as on antigen-presenting cells.
intercellular adhesion molecule Binding (binds) of LFA-1 in epithelial cells associated with adhesions
5) Confidence 0.04 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727880 Disease Relevance 0.68 Pain Relevance 0.22

General Comments

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