INT71188

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Context Info
Confidence 0.44
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.58
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Anatomy Link Frequency
plasma 2
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 8 98.80 Very High Very High Very High
Antihistamine 10 96.08 Very High Very High Very High
Potency 1 72.64 Quite High
Inflammation 8 50.00 Quite Low
Migraine 1 43.00 Quite Low
Onset of action 3 17.92 Low Low
Bile 11 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
pruritus 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Arrhythmogenic Right Ventricular Dysplasia 1 95.08 Very High Very High Very High
Sprains And Strains 1 86.24 High High
Targeted Disruption 15 77.44 Quite High
Hepatotoxicity 3 75.00 Quite High
Conjunctiva Disease 23 59.24 Quite High
Severe Combined Immunodeficiency 6 57.08 Quite High
INFLAMMATION 16 50.00 Quite Low
Vomiting 1 43.52 Quite Low
Headache 1 43.00 Quite Low
Hypersensitivity 34 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Patients should be cautioned about the drug interaction of Wu-chu-yu-tang and CYP1A2 substrates.
CYP1A2 Binding (interaction) of
1) Confidence 0.44 Published 2002 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 12184732 Disease Relevance 0 Pain Relevance 0
A statistically significant association (log-likelihood ratio = 25.0) between a locus on chromosome 9, which colocalized with the murine Cyp1a2 locus, and the plasma paraxanthine/caffeine ratio was identified.
Cyp1a2 Binding (colocalized) of in plasma
2) Confidence 0.37 Published 1999 Journal Drug Metab. Dispos. Section Abstract Doc Link 10570017 Disease Relevance 0.09 Pain Relevance 0.09
In vivo caffeine 3-demethylation, which is associated with CYP1A2 activity, co-segregated with acetaminophen susceptibility and showed a significant positive correlation (r = 0.626, p < 0.005) with CYP1A2 mRNA expression in animals from both the susceptible and nonsusceptible groups.
CYP1A2 Binding (associated) of associated with paracetamol
3) Confidence 0.36 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.20 Pain Relevance 0.51
The binding of 3-MC to the aryl hydrocarbon receptor (AHR) forms a AHR/3-MC complex, which upregulates CYP1A1, CYP1A2, and CYP1B1 expression by binding, together with the AHR nuclear translocator (ARNT), to the XREs of these genes [30].
CYP1A2 Binding (binding) of
4) Confidence 0.22 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.13 Pain Relevance 0.04
Of particular concern are the arrhythmogenic changes in the QTc interval when an antihistamine, such as terfenadine, is administered orally along with either ketoconazole or erythromycin.24 Even though azelastine is more than 90% metabolized by CYP3A4 and CYP2D6, and to a lesser extent by CYP1A2,19 such drug interactions are unlikely to be due to the low plasma concentration of azelastine and N-desmethylazelastine after topical administration.


CYP1A2 Binding (interactions) of in plasma associated with antihistamine and arrhythmogenic right ventricular dysplasia
5) Confidence 0.13 Published 2010 Journal Clinical Ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2938280 Disease Relevance 0.15 Pain Relevance 0.05

General Comments

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