INT71194

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Context Info
Confidence 0.15
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 93.44 High High
Potency 1 55.12 Quite High
palliative 1 32.96 Quite Low
Bile 11 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Skin Cancer 9 99.68 Very High Very High Very High
Hepatotoxicity 6 94.36 High High
Severe Combined Immunodeficiency 6 86.00 High High
Targeted Disruption 15 5.00 Very Low Very Low Very Low
Hepatitis C Virus Infection 9 5.00 Very Low Very Low Very Low
Hepatitis B Virus Infection 8 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Hepatitis 4 5.00 Very Low Very Low Very Low
Viremia 3 5.00 Very Low Very Low Very Low
Liver Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further examination of both CYP1A isoforms revealed that hepatic CYP1A1 and CYP1A2 mRNA and protein levels were significantly elevated in animals from the susceptible group.
Transcription (levels) of CYP1A1
1) Confidence 0.15 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.20 Pain Relevance 0.51
This was supported by the correlated expression of both CYP1A mRNAs within individual mice (r = 0.644, p < 0.02).
Transcription (expression) of CYP1A
2) Confidence 0.15 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.30
RNA for vitamin D-activating enzymes vitamin D-25-hydroxylase (25OHase, CYP27A1) and 25-hydroxyvitamin D-lalpha-hydroxylase (lalphaOHase, CYP27B1) was detected in all melanoma cell lines analyzed, additionally we show splicing variants of lalphaOHase in SK-Mel-28 cells.
Transcription (detected) of CYP27B1 associated with skin cancer
3) Confidence 0.09 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172823 Disease Relevance 0.54 Pain Relevance 0
The administration of 3-MC enhanced CYP1A1 and CYP1A2 mRNA levels by 10.0-fold and 6.4-fold, respectively, but had no effect on the other four CYPs.
Transcription (levels) of CYP1A1
4) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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