INT71194

Context Info Confidence 0.15 First Reported 1997 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 0.99 Pain Relevance 0.84

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1) cytoplasm (Cyp27b1)

Cyp27b1 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 14 93.44 Potency 1 55.12 palliative 1 32.96 Bile 11 5.00 diclofenac 2 5.00 agonist 2 5.00 adenocard 1 5.00 Morphine 1 5.00

Disease Link Frequency Relevance Heat Skin Cancer 9 99.68 Hepatotoxicity 6 94.36 Severe Combined Immunodeficiency 6 86.00 Targeted Disruption 15 5.00 Hepatitis C Virus Infection 9 5.00 Hepatitis B Virus Infection 8 5.00 Infection 6 5.00 Hepatitis 4 5.00 Viremia 3 5.00 Liver Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Further examination of both CYP1A isoforms revealed that hepatic CYP1A1 and CYP1A2 mRNA and protein levels were significantly elevated in animals from the susceptible group.

Transcription (levels) of CYP1A1

1) Confidence 0.15 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.20 Pain Relevance 0.51

This was supported by the correlated expression of both CYP1A mRNAs within individual mice (r = 0.644, p < 0.02).

Transcription (expression) of CYP1A

2) Confidence 0.15 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.30

RNA for vitamin D-activating enzymes vitamin D-25-hydroxylase (25OHase, CYP27A1) and 25-hydroxyvitamin D-lalpha-hydroxylase (lalphaOHase, CYP27B1) was detected in all melanoma cell lines analyzed, additionally we show splicing variants of lalphaOHase in SK-Mel-28 cells.

Transcription (detected) of CYP27B1 associated with skin cancer

3) Confidence 0.09 Published 2007 Journal Cancer Biol. Ther. Section Abstract Doc Link 17172823 Disease Relevance 0.54 Pain Relevance 0

The administration of 3-MC enhanced CYP1A1 and CYP1A2 mRNA levels by 10.0-fold and 6.4-fold, respectively, but had no effect on the other four CYPs.

Transcription (levels) of CYP1A1

4) Confidence 0.01 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.09 Pain Relevance 0.03

General Comments

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