INT71195

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Context Info
Confidence 0.53
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.41
Pain Relevance 3.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 45 99.00 Very High Very High Very High
Potency 1 55.12 Quite High
Bile 11 5.00 Very Low Very Low Very Low
diclofenac 2 5.00 Very Low Very Low Very Low
agonist 2 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 14 99.54 Very High Very High Very High
Hepatotoxicity 17 92.64 High High
Severe Combined Immunodeficiency 6 86.00 High High
Targeted Disruption 17 66.16 Quite High
Hepatitis C Virus Infection 9 5.00 Very Low Very Low Very Low
Hepatitis B Virus Infection 8 5.00 Very Low Very Low Very Low
Infection 6 5.00 Very Low Very Low Very Low
Hepatitis 4 5.00 Very Low Very Low Very Low
Toxicity 3 5.00 Very Low Very Low Very Low
Viremia 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Microsomal methoxyresorufin O-demethylation, acetanilide 4-hydroxylation, and CYP1A2 immunoreactive protein levels were significantly higher in C3H/HeJ relative to APN mice, as were hepatic CYP1A2 mRNA levels.
Transcription (levels) of CYP1A2 associated with sprains and strains
1) Confidence 0.53 Published 1997 Journal Fundam Appl Toxicol Section Abstract Doc Link 9441719 Disease Relevance 1.12 Pain Relevance 0.07
In vivo caffeine 3-demethylation, which is associated with CYP1A2 activity, co-segregated with acetaminophen susceptibility and showed a significant positive correlation (r = 0.626, p < 0.005) with CYP1A2 mRNA expression in animals from both the susceptible and nonsusceptible groups.
Transcription (expression) of CYP1A2 associated with paracetamol
2) Confidence 0.53 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.16 Pain Relevance 0.45
Further examination of both CYP1A isoforms revealed that hepatic CYP1A1 and CYP1A2 mRNA and protein levels were significantly elevated in animals from the susceptible group.
Transcription (levels) of CYP1A2
3) Confidence 0.53 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.20 Pain Relevance 0.51
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Transcription (expression) of Cyp1a2 associated with paracetamol
4) Confidence 0.50 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.43 Pain Relevance 1.10
The administration of 3-MC enhanced CYP1A1 and CYP1A2 mRNA levels by 10.0-fold and 6.4-fold, respectively, but had no effect on the other four CYPs.
Transcription (levels) of CYP1A2
5) Confidence 0.44 Published 2009 Journal PPAR Research Section Body Doc Link PMC2768028 Disease Relevance 0.09 Pain Relevance 0.03
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Transcription (levels) of Cyp1a2 associated with paracetamol
6) Confidence 0.43 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.42 Pain Relevance 1.09

General Comments

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