INT71197

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Context Info
Confidence 0.20
First Reported 1997
Last Reported 2001
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.49
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Cyp27b1) oxidoreductase activity (Cyp27b1) aging (Cyp27b1)
cytoplasm (Cyp27b1)
Anatomy Link Frequency
liver 2
Cyp27b1 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 98.00 Very High Very High Very High
headache 1 62.32 Quite High
Disease Link Frequency Relevance Heat
Hepatotoxicity 6 97.12 Very High Very High Very High
Headache 1 62.32 Quite High
Gastrointestinal Disease 1 61.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoblot analysis of microsomal proteins showed that rutaecarpine-treatment increased the protein levels of CYP1A1 and CYP1A2 in the liver, whereas hepatic level of CYP3A-immunoreacted protein was not affected by rutaecarpine.
Positive_regulation (increased) of Gene_expression (levels) of CYP1A1 in liver
1) Confidence 0.20 Published 2001 Journal Life Sci. Section Abstract Doc Link 11787945 Disease Relevance 0.12 Pain Relevance 0.06
Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity.
Positive_regulation (Increased) of Gene_expression (expression) of Cyp1a1 associated with paracetamol and hepatotoxicity
2) Confidence 0.20 Published 1997 Journal Pharmacogenetics Section Title Doc Link 9295056 Disease Relevance 0.19 Pain Relevance 0.43
The co-segregation of elevated basal Cyp1a1 and CYP1a2 gene expression levels in animals selected for susceptibility to acetaminophen-induced hepatotoxicity suggested a common heritable basis for regulation of basal expression of both of these CYP1A isoforms.
Positive_regulation (elevated) of Gene_expression (expression) of Cyp1a1 associated with paracetamol and hepatotoxicity
3) Confidence 0.14 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.39

General Comments

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