INT71199

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.41
Pain Relevance 3.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
Anatomy Link Frequency
hepatocytes 2
Cyp1a2 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 45 100.00 Very High Very High Very High
agonist 5 86.88 High High
Antiemetics 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 17 97.12 Very High Very High Very High
Vomiting 1 79.36 Quite High
Targeted Disruption 2 70.56 Quite High
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The co-segregation of elevated basal Cyp1a1 and CYP1a2 gene expression levels in animals selected for susceptibility to acetaminophen-induced hepatotoxicity suggested a common heritable basis for regulation of basal expression of both of these CYP1A isoforms.
Positive_regulation (elevated) of Gene_expression (expression) of CYP1a2 associated with paracetamol and hepatotoxicity
1) Confidence 0.69 Published 1997 Journal Pharmacogenetics Section Abstract Doc Link 9295056 Disease Relevance 0.17 Pain Relevance 0.39
Increased basal expression of hepatic Cyp1a1 and Cyp1a2 genes in inbred mice selected for susceptibility to acetaminophen-induced hepatotoxicity.
Positive_regulation (Increased) of Gene_expression (expression) of Cyp1a2 associated with paracetamol and hepatotoxicity
2) Confidence 0.50 Published 1997 Journal Pharmacogenetics Section Title Doc Link 9295056 Disease Relevance 0.19 Pain Relevance 0.44
In contrast, meclizine suppresses hCAR transactivation and inhibits the phenobarbital-induced expression of the CAR target genes, cytochrome p450 monooxygenase (CYP)2B10, CYP3A11, and CYP1A2, in primary hepatocytes derived from mice expressing hCAR, but not mCAR.
Positive_regulation (induced) of Gene_expression (expression) of CYP1A2 in hepatocytes
3) Confidence 0.47 Published 2004 Journal Mol. Endocrinol. Section Abstract Doc Link 15272053 Disease Relevance 0.17 Pain Relevance 0.29
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Positive_regulation (observed) of Gene_expression (expression) of Cyp1a2 associated with paracetamol
4) Confidence 0.47 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.44 Pain Relevance 1.12
Lower basal Cyp1a2 mRNA levels and lower expression of Cyp1a2 and Cyp3a11 mRNAs after APAP dosing were also observed in females compared with males.
Positive_regulation (observed) of Gene_expression (expression) of Cyp1a2 associated with paracetamol
5) Confidence 0.41 Published 2006 Journal Toxicol. Sci. Section Abstract Doc Link 16611625 Disease Relevance 0.44 Pain Relevance 1.13

General Comments

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