INT712

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Context Info
Confidence 0.70
First Reported 1977
Last Reported 2011
Negated 11
Speculated 6
Reported most in Abstract
Documents 160
Total Number 168
Disease Relevance 175.25
Pain Relevance 19.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (LDHA) small molecule metabolic process (LDHA) oxidoreductase activity (LDHA)
cytoplasm (LDHA)
Anatomy Link Frequency
liver 10
blood 6
lymph nodes 5
plasma 4
platelet 4
LDHA (Homo sapiens)
Pain Link Frequency Relevance Heat
abdominal pain 57 99.90 Very High Very High Very High
Angina 45 99.88 Very High Very High Very High
Fibrositis 77 99.78 Very High Very High Very High
backache 6 99.76 Very High Very High Very High
Pain 231 99.24 Very High Very High Very High
headache 102 98.86 Very High Very High Very High
cva 106 98.46 Very High Very High Very High
Inflammation 431 98.32 Very High Very High Very High
Calcitonin gene-related peptide 24 98.08 Very High Very High Very High
imagery 164 97.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 1166 100.00 Very High Very High Very High
Metastasis 400 100.00 Very High Very High Very High
Chronic Hepatitis 248 100.00 Very High Very High Very High
Breast Cancer 146 100.00 Very High Very High Very High
Recurrence 122 100.00 Very High Very High Very High
Injury 81 100.00 Very High Very High Very High
Myalgia 18 100.00 Very High Very High Very High
Arrhythmias 2 Under Development 14 100.00 Very High Very High Very High
Disorders Of Creatine Metabolism 8 100.00 Very High Very High Very High
Anaemia 149 99.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
After 60 minutes of exposure, ioxaglate at the higher concentration (150 mg iodine per milliliter) significantly increased the LDH signal (ie, the percentage of LDH released), to 20%.
Positive_regulation (increased) of LDH
1) Confidence 0.70 Published 2001 Journal Acad Radiol Section Body Doc Link 11227644 Disease Relevance 0.22 Pain Relevance 0
Two patients, one 76-year-old-man and one 79-year-old-woman with cardiovascular disease and one 36-year-old-man with Factor-V-Leiden deficiency (activated protein C-resistance) had abdominal pain and elevation of LDH levels.
Positive_regulation (elevation) of LDH associated with abdominal pain and cardiovascular disease
2) Confidence 0.70 Published 1998 Journal Ned Tijdschr Geneeskd Section Abstract Doc Link 10028329 Disease Relevance 0.45 Pain Relevance 0.18
Serum LDH was elevated.
Positive_regulation (elevated) of LDH
3) Confidence 0.70 Published 1992 Journal Nihon Kyobu Shikkan Gakkai Zasshi Section Abstract Doc Link 1405109 Disease Relevance 1.04 Pain Relevance 0.10
Marked increases in LDH activity were noted in the blister fluid of IPPSFs treated with 5.0 mg/ml of L.
Positive_regulation (increases) of LDH associated with blister
4) Confidence 0.70 Published 1992 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 1412463 Disease Relevance 0.49 Pain Relevance 0.06
He was admitted in June, 1994, for continuous back pain and marked elevation of serum lactate dehydrogenase.
Positive_regulation (elevation) of serum lactate dehydrogenase associated with backache
5) Confidence 0.69 Published 1995 Journal Gan To Kagaku Ryoho Section Abstract Doc Link 8607624 Disease Relevance 1.06 Pain Relevance 0.10
This conflicts with previous data where increased glass fiber concentration decreased chemiluminescence and increased LDH in rat alveolar macrophages but major length-dependent effects were evident.
Positive_regulation (increased) of LDH in alveolar macrophages
6) Confidence 0.69 Published 2006 Journal Part Fibre Toxicol Section Body Doc Link PMC1459188 Disease Relevance 0 Pain Relevance 0
In addition, LDH and CK activities were elevated to a greater extent in the vitamin C and NAC group.
Positive_regulation (elevated) of LDH
7) Confidence 0.67 Published 2001 Journal Free Radic. Biol. Med. Section Abstract Doc Link 11557312 Disease Relevance 1.27 Pain Relevance 0.26
It is concluded that, pleural biopsy is the most effective diagnostic method for the tuberculous pleurisy and in the patient with elevated pleural LDH level, pleural thickening seems more.
Positive_regulation (elevated) of LDH in thickening associated with pleural tuberculosis
8) Confidence 0.67 Published 2004 Journal Tuberk Toraks Section Abstract Doc Link 15241697 Disease Relevance 0.42 Pain Relevance 0.08
During a 90-min perfusion period, no elevation of either GOT, GPT, or LDH was found.
Neg (no) Positive_regulation (elevation) of LDH
9) Confidence 0.67 Published 2001 Journal Drug Metab. Dispos. Section Abstract Doc Link 11353741 Disease Relevance 0.39 Pain Relevance 0.26
Laboratory studies showed markedly elevated liver enzymes, elevated lactate dehydrogenase, anemia, thrombocytopenia, and acute renal failure.
Positive_regulation (elevated) of lactate dehydrogenase in liver associated with acute renal failure, anaemia and thrombocytopenia
10) Confidence 0.67 Published 2003 Journal Am. J. Med. Sci. Section Abstract Doc Link 14671503 Disease Relevance 1.34 Pain Relevance 0.09
All patients experience significant anemia, severe thrombocytopenia, increased lactate dehydrogenase, elevated serum creatinine, and oliguria.
Positive_regulation (increased) of lactate dehydrogenase associated with anaemia, oliguria and thrombocytopenia
11) Confidence 0.67 Published 1994 Journal Am. J. Hematol. Section Abstract Doc Link 7977300 Disease Relevance 1.72 Pain Relevance 0.09
Non-functioning adrenal carcinoma was suspected from the laboratory data of elevated lactate dehydrogenase level and total amount of urinary excretion of 17-ketosteroid.
Positive_regulation (elevated) of lactate dehydrogenase associated with adrenal cancer
12) Confidence 0.67 Published 1988 Journal Hinyokika Kiyo Section Abstract Doc Link 3245526 Disease Relevance 0.80 Pain Relevance 0.10
Anemia and elevation of lactate dehydrogenase were uniformly present during acute evaluation.
Positive_regulation (elevation) of lactate dehydrogenase associated with anaemia
13) Confidence 0.67 Published 1990 Journal Surg Gynecol Obstet Section Abstract Doc Link 2300864 Disease Relevance 0.73 Pain Relevance 0.22
Results of ALT and AST were minimally elevated in 1 and 4 patients respectively with the highest value being an ALT of 86 in patient #6 (data not shown in table) while LDH was elevated in 10 patients.
Positive_regulation (elevated) of LDH
14) Confidence 0.66 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1885437 Disease Relevance 1.61 Pain Relevance 0.30
During a 90-min perfusion period, no elevation of either GOT, GPT, or LDH was found.
Neg (no) Positive_regulation (elevation) of LDH
15) Confidence 0.66 Published 2001 Journal Drug Metab. Dispos. Section Abstract Doc Link 11259317 Disease Relevance 0.39 Pain Relevance 0.26
On initial urinalysis, both patients showed no hematuria, but the plasma lactate dehydrogenase level was markedly elevated with little or no rise in plasma transaminases.
Positive_regulation (elevated) of plasma lactate dehydrogenase in plasma associated with hematuria
16) Confidence 0.65 Published 2004 Journal Hypertens. Res. Section Abstract Doc Link 15302990 Disease Relevance 0.68 Pain Relevance 0.14
An elevated creatinine-kinase and lactate-dehydrogenase were found.
Positive_regulation (elevated) of lactate-dehydrogenase
17) Confidence 0.63 Published 1993 Journal Schweiz. Rundsch. Med. Prax. Section Abstract Doc Link 8265941 Disease Relevance 0.59 Pain Relevance 0.08
Our results can, however, be biased by the fact that an increase of LDH is also seen with intake of azathioprine, a drug that was given to all patients in this study.
Positive_regulation (increase) of LDH
18) Confidence 0.59 Published 2010 Journal Respir Res Section Body Doc Link PMC2907324 Disease Relevance 0.98 Pain Relevance 0.05
Mild anemia, leukocytosis, positive CRP and a high level of LDH were noted.
Positive_regulation (level) of LDH associated with anaemia and leukocytosis
19) Confidence 0.58 Published 1991 Journal Rinsho Ketsueki Section Abstract Doc Link 2020115 Disease Relevance 1.16 Pain Relevance 0.08
When examining the children diagnosed with leukemia (the most common diagnosis) (N = 13), 12 (92%) had low hemoglobin, 11 (85%) had an abnormal white blood cell differential, 10 (77%) had decreased platelets, 10 (77%) had fever, 9 (69%) had an elevated LDH, 6 (46%) had hepatomegaly, 8 (62%) had splenomegaly, 6 (46%) had a decreased white blood cell count, 4 (31%) fatigue, 4 (31%) weight loss, 4 (31%) headache and 4 (31%) had an elevated white blood cell count.
Positive_regulation (elevated) of LDH in white blood cell associated with leukemia, weight loss, splenomegaly, fatigue, hepatomegaly, headache and fever
20) Confidence 0.58 Published 2007 Journal BMC Infect Dis Section Body Doc Link PMC1885437 Disease Relevance 1.62 Pain Relevance 0.25

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