INT71220

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Context Info
Confidence 0.38
First Reported 1997
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 10.23
Pain Relevance 5.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
cortex 2
spinal cord 1
nerve 1
pulmonary artery 1
dorsal horn 1
Casp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 31 100.00 Very High Very High Very High
Neuritis 5 99.76 Very High Very High Very High
Hippocampus 8 99.16 Very High Very High Very High
Thermal hyperalgesia 2 99.14 Very High Very High Very High
Dopamine 6 99.12 Very High Very High Very High
antagonist 42 98.72 Very High Very High Very High
Morphine 17 98.52 Very High Very High Very High
Inflammation 40 97.96 Very High Very High Very High
Spinal cord 15 96.72 Very High Very High Very High
Dorsal horn 7 95.88 Very High Very High Very High
Disease Link Frequency Relevance Heat
Necrosis 6 100.00 Very High Very High Very High
Cancer 3 100.00 Very High Very High Very High
Brain Injury 33 99.92 Very High Very High Very High
Hypoxia 2 99.82 Very High Very High Very High
Apoptosis 41 99.80 Very High Very High Very High
Experimental Autoimmune Neuritis 5 99.76 Very High Very High Very High
Injury 30 99.72 Very High Very High Very High
Hyperalgesia 5 99.14 Very High Very High Very High
Increased Venous Pressure Under Development 9 99.08 Very High Very High Very High
Disease Progression 1 98.88 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These observations suggest that the apoptosis of gastric mucosal cells could be involved in IND-induced gastropathy, that cytochrome c is released from mitochondria into the cytosol during the early phase of IND-mediated apoptosis, and that subsequent activation of caspase-3-like protease, but not caspase-1-like protease, is required for the execution of apoptosis.
Positive_regulation (activation) of caspase-1-like associated with apoptosis
1) Confidence 0.38 Published 2000 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 10806417 Disease Relevance 0.84 Pain Relevance 0
Caspase-1 mRNA content also was increased after trauma, but to a lesser extent in cortex.
Positive_regulation (increased) of Caspase-1 mRNA in cortex associated with injury
2) Confidence 0.34 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295387 Disease Relevance 0.90 Pain Relevance 0.29
These data suggest a critical role for the cytokine IL-1beta and caspase 1 rapidly released by activated microglia in enhancing nociceptive transmission in spinal cord inflammation.
Positive_regulation (role) of caspase 1 in spinal cord associated with nociception, inflammation, spinal cord and cytokine
3) Confidence 0.32 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.67 Pain Relevance 0.65
In EAN, IL-18 and caspase-1 mRNA levels in the nerve roots increased during the stage of active disease progression.
Positive_regulation (increased) of caspase-1 mRNA in nerve associated with neuritis and disease progression
4) Confidence 0.26 Published 2001 Journal J. Neuroimmunol. Section Abstract Doc Link 11240039 Disease Relevance 1.41 Pain Relevance 0.70
Increased caspase-3-like, but not caspase-1-like, enzymatic activity was found in cytosolic extracts from injured cortex.
Neg (not) Positive_regulation (Increased) of caspase-1-like in cortex
5) Confidence 0.24 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295387 Disease Relevance 0.90 Pain Relevance 0.34
The effector phase of morphine-induced apoptosis appears to proceed through the accumulation of Bax and activation of ICE-1.
Positive_regulation (activation) of ICE-1 associated with apoptosis and morphine
6) Confidence 0.19 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9469450 Disease Relevance 0.63 Pain Relevance 1.26
LPS superfusion also induced rapid secretion of active caspase 1 and apoptosis-associated speck-like protein containing a caspase recruitment domain from the isolated dorsal horn.
Positive_regulation (induced) of caspase 1 in dorsal horn associated with dorsal horn and apoptosis
7) Confidence 0.15 Published 2006 Journal J. Neurochem. Section Abstract Doc Link 16942597 Disease Relevance 0.65 Pain Relevance 0.54
All three agents induced vasorelaxation in pulmonary artery rings precontracted with phenylephrine, but only tadalafil significantly attenuated hypoxia-induced vasoconstriction and significantly attenuated hypoxia-induced upregulation of tumor necrosis factor alfa and interleukin-1 beta messenger RNA.
Positive_regulation (upregulation) of interleukin-1 beta messenger RNA in pulmonary artery associated with necrosis, cancer, hypoxia and increased venous pressure under development
8) Confidence 0.10 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012445 Disease Relevance 1.25 Pain Relevance 0
Furthermore, the levels of TNF-alpha receptor R1 (TNF-R1, p55), bcl-2, soluble Fas (sFas), and the activities of caspase-1 and caspase-3 were also elevated in the nigrostriatal DA regions in PD.
Positive_regulation (elevated) of caspase-1 associated with dopamine and disease
9) Confidence 0.08 Published 2000 Journal J. Neural Transm. Suppl. Section Abstract Doc Link 11205147 Disease Relevance 1.12 Pain Relevance 0.61
IL-1beta-induced NO levels and thermal hyperalgesia in rats, likely via either inhibiting the IL-1beta-mediated p38 MAPK activation and subsequent iNOS induction, or direct attenuation of the central iNOS activity, which therefore reduces the central sensitization of inflammatory pain.
Spec (likely) Positive_regulation (activation) of IL-1beta-mediated associated with central sensitization, ipn and thermal hyperalgesia
10) Confidence 0.04 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.68 Pain Relevance 0.93
The secretion of mature and bioactive IL-1ß and IL-18 depends on the activity of the enzyme caspase-1, a limiting step in the biosynthesis of these pro-inflammatory cytokines.
Positive_regulation (depends) of caspase-1 associated with inflammation and cytokine
11) Confidence 0.04 Published 2008 Journal Intensive Care Med Section Body Doc Link PMC2228383 Disease Relevance 0.86 Pain Relevance 0.46
CONCLUSION: M299V is an activating mutation in NLRP3 resulting in elevated spontaneous caspase 1 activity and IL-1beta levels.
Positive_regulation (elevated) of caspase 1
12) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506209 Disease Relevance 0 Pain Relevance 0
The samples obtained from the patients displayed increased caspase 1 activity and elevated IL-1beta levels at basal conditions as compared with healthy control subjects.
Positive_regulation (increased) of caspase 1
13) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506209 Disease Relevance 0 Pain Relevance 0
The samples obtained from the patients displayed increased caspase 1 activity and elevated IL-1beta levels at basal conditions as compared with healthy control subjects.
Positive_regulation (elevated) of caspase 1
14) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Body Doc Link 20506209 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: The NALP3 inflammasome is a multiprotein complex that triggers caspase 1-mediated interleukin-1beta (IL-1beta) release.
Positive_regulation (triggers) of caspase 1
15) Confidence 0.04 Published 2010 Journal Arthritis Rheum. Section Abstract Doc Link 20506209 Disease Relevance 0.17 Pain Relevance 0
P2X7 receptor-mediated changes in intracellular potassium concentrations lead to the activation of caspase-1 and the rapid maturation and release of the proinflammatory cytokine, interleukin-1?
Positive_regulation (activation) of caspase-1 associated with cytokine
16) Confidence 0.04 Published 2008 Journal Purinergic Signal Section Body Doc Link PMC2721772 Disease Relevance 0.16 Pain Relevance 0.05

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