INT71221

Context Info Confidence 0.55 First Reported 1997 Last Reported 1997 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 1.81 Pain Relevance 1.05

cell proliferation (Prkar1b) signal transduction (Prkar1b) cytoplasm (Prkar1b)

Anatomy Link Frequency dorsal root ganglion 1 Prkar1b (Mus musculus)

Pain Link Frequency Relevance Heat Pain 5 99.44 dorsal root ganglion 1 97.12 Inflammation 4 95.24 primary afferent fibers 1 90.32 intrathecal 1 85.96 qutenza 2 81.64 Dorsal horn 1 76.00 Neuropathic pain 1 75.00 painful pain 1 75.00 Lasting pain 1 73.32

Disease Link Frequency Relevance Heat Pain 6 99.44 Neuropathic Pain 2 99.20 Nervous System Injury 2 98.40 Nociception 4 96.68 Ganglion Cysts 1 96.64 Injury 3 95.88 INFLAMMATION 4 95.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Because the RIbeta subunit is only present in the nervous system, including small diameter trkA receptor-positive dorsal root ganglion cells, we suggest that in inflammatory conditions, RIbeta PKA is specifically required for nociceptive processing in the terminals of small-diameter primary afferent fibers.

Gene_expression (present) of RIbeta in dorsal root ganglion associated with nociception, ganglion cysts, dorsal root ganglion, inflammation and primary afferent fibers

1) Confidence 0.55 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9295392 Disease Relevance 1.81 Pain Relevance 1.05

General Comments

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