INT71230

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Context Info
Confidence 0.55
First Reported 1997
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 4.75
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
paw 1
brain 1
platelet 1
asa (Mus musculus)
Pain Link Frequency Relevance Heat
aspirin 40 100.00 Very High Very High Very High
Paracetamol 40 100.00 Very High Very High Very High
Antinociceptive 14 99.74 Very High Very High Very High
anesthesia 2 99.44 Very High Very High Very High
Serotonin 4 98.96 Very High Very High Very High
antagonist 2 98.20 Very High Very High Very High
Pain threshold 2 98.08 Very High Very High Very High
Analgesic 9 96.28 Very High Very High Very High
Angina 8 93.68 High High
Eae 8 92.24 High High
Disease Link Frequency Relevance Heat
Fever 4 100.00 Very High Very High Very High
Myocardial Infarction 10 99.16 Very High Very High Very High
Pressure And Volume Under Development 4 98.16 Very High Very High Very High
Pain 10 98.08 Very High Very High Very High
Pancreatic Cancer 1 97.84 Very High Very High Very High
Cancer 122 95.68 Very High Very High Very High
Nociception 2 95.00 High High
Colon Cancer 18 94.20 High High
Cv General 3 Under Development 6 93.68 High High
Inflammatory Pain 4 91.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To clarify the target of ASA action in melanogenesis, we performed Western blotting for tyrosinase, which is a key melanogenic enzyme.
Regulation (target) of ASA
1) Confidence 0.55 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18175938 Disease Relevance 0.55 Pain Relevance 0.17
the control group, NO-ASA reduced the incidence and multiplicity of pancreatic
Regulation (control) of NO-ASA
2) Confidence 0.15 Published 2008 Journal PPAR Research Section Body Doc Link PMC2408682 Disease Relevance 1.04 Pain Relevance 0.04
These data indicate that the central antinociceptive activity of ASA is modulated in a different manner by serotonin receptor antagonists, and that 5-HT(2) and 5-HT(3) receptors may exert a pivotal role in nociception, alone or in association.
Regulation (modulated) of ASA associated with nociception, antagonist, serotonin and antinociceptive
3) Confidence 0.13 Published 2002 Journal Pharmacology Section Abstract Doc Link 12119448 Disease Relevance 0.17 Pain Relevance 0.42
The antinociceptive activity of ASA in the hot-plate test was variously affected by ondansetron, ketanserin and NAN-190: at the highest dose (2 mg/kg s.c.) ondansetron abolished it while ketanserin (5 mg/kg s.c.) significantly reduced it, and NAN-190 (1-5 mg/kg) did not significantly modify the effect of ASA.
Regulation (affected) of ASA associated with antinociceptive
4) Confidence 0.13 Published 2002 Journal Pharmacology Section Abstract Doc Link 12119448 Disease Relevance 0.10 Pain Relevance 0.40
Caffeine additively increases the acute antiexudative effect of ASA and aminophenazone on the carageenin-induced oedema of the hind paw of the rat.
Regulation (effect) of ASA in paw associated with pressure and volume under development
5) Confidence 0.13 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9296278 Disease Relevance 0.50 Pain Relevance 1.10
The antipyretic effect of ASA and paracetamol on the yeast-induced pyrexia of the rat is not affected by caffeine.
Regulation (effect) of ASA associated with paracetamol and fever
6) Confidence 0.13 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9296278 Disease Relevance 0.44 Pain Relevance 1.09
The inhibitory effect of paracetamol and ASA on the prostaglandin biosynthesis in a cyclooxygenase preparation from bovine brain in vitro was not affected by the addition of caffeine.
Neg (not) Regulation (affected) of ASA in brain associated with paracetamol
7) Confidence 0.13 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9296278 Disease Relevance 0.24 Pain Relevance 0.97
The antipyretic effect of ASA and paracetamol on the yeast-induced pyrexia of the rat is not affected by caffeine.
Neg (not) Regulation (affected) of ASA associated with paracetamol and fever
8) Confidence 0.13 Published 1997 Journal Arzneimittelforschung Section Abstract Doc Link 9296278 Disease Relevance 0.50 Pain Relevance 1.15
There is evidence for platelet hyper-function and elevated von Willebrand factor levels in the MI group that could explain their decreased responsiveness to ASA on the collagen/epinephrine cartridge.
Regulation (responsiveness) of ASA in platelet associated with aspirin and myocardial infarction
9) Confidence 0.02 Published 2005 Journal Blood Coagul. Fibrinolysis Section Abstract Doc Link 16269928 Disease Relevance 0.86 Pain Relevance 0.53
The sensitivity of the ASA-classification for evaluation of the nutritional status was 0.33, selectivity was 0.87, positive predictive value was 0.58 and negative predictive value was 0.70.
Regulation (sensitivity) of ASA
10) Confidence 0.01 Published 2004 Journal Anasthesiol Intensivmed Notfallmed Schmerzther Section Body Doc Link 15273928 Disease Relevance 0 Pain Relevance 0
Sensitivity of ASA scoring to differentiate the proportion of patients belonging to ASA II vs III (Leung and Dzankic 2001), where both groups show a similar mortality under elective conditions (15%) is poor.
Regulation (Sensitivity) of ASA
11) Confidence 0.00 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2695183 Disease Relevance 0.34 Pain Relevance 0.10

General Comments

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