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Context Info
Confidence 0.01
First Reported 1997
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.24

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endosome (MMD) plasma membrane (Ppyr1) signal transducer activity (Ppyr1)
Anatomy Link Frequency
cerebral cortex 1
MMD (Homo sapiens)
Ppyr1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cerebral cortex 4 98.00 Very High Very High Very High
anesthesia 1 94.72 High High


Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Taken together, these results suggest that MMA, at the same concentrations found in tissues of methylmalonic acidemic children, inhibits the in vitro activities of PKA, CaMKII and PP1 associated with the cytoskeletal fraction of the cerebral cortex of rats, a fact that may be involved with the pathogenesis of the neurological dysfunction characteristic of methylmalonic acidemia.
MMA Negative_regulation (inhibits) of PP1 in cerebral cortex associated with anesthesia and cerebral cortex
1) Confidence 0.01 Published 1997 Journal Brain Res. Section Abstract Doc Link 9296563 Disease Relevance 0 Pain Relevance 0.24

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