INT71273

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Context Info
Confidence 0.42
First Reported 1997
Last Reported 2006
Negated 1
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.80
Pain Relevance 2.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Comp) extracellular region (Comp) cell adhesion (Comp)
proteinaceous extracellular matrix (Comp) extracellular matrix organization (Comp)
Anatomy Link Frequency
cartilage 2
synovial fluid 1
acinar cells 1
Comp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 63 99.80 Very High Very High Very High
Arthritis 102 98.52 Very High Very High Very High
gABA 24 97.84 Very High Very High Very High
rheumatoid arthritis 37 97.64 Very High Very High Very High
Osteoarthritis 14 97.32 Very High Very High Very High
Dopamine 321 95.68 Very High Very High Very High
Pain 6 91.84 High High
imagery 13 88.40 High High
Snapping jaw 3 77.72 Quite High
Nucleus accumbens 15 50.00 Quite Low
Disease Link Frequency Relevance Heat
Arthritis 102 98.52 Very High Very High Very High
Rheumatoid Arthritis 38 97.64 Very High Very High Very High
Osteoarthritis 11 97.32 Very High Very High Very High
Disease 43 96.00 Very High Very High Very High
Pain 6 91.84 High High
Knee Osteoarthritis 7 82.40 Quite High
Pancreatic Cancer 2 81.88 Quite High
Pancreatitis 6 80.96 Quite High
Hypersensitivity 4 79.28 Quite High
Recurrence 1 78.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
COMP mRNA signals and immunoreactivity were strongly present in the cytoplasm of degenerating acinar cells in CP tissues as well as in CP-like lesions in pancreatic cancer tissues.
Positive_regulation (present) of COMP mRNA in acinar cells
1) Confidence 0.42 Published 2003 Journal Scand. J. Gastroenterol. Section Body Doc Link 12678339 Disease Relevance 0.16 Pain Relevance 0
Serum concentrations of cartilage oligomeric matrix protein (COMP) and bone sialoprotein (BSP) increased significantly (P < 0.001) in the 23 individuals with radiographic OA at follow-up, while remaining unchanged in the 15 individuals with normal radiographs at follow-up.
Positive_regulation (increased) of COMP in cartilage associated with osteoarthritis
2) Confidence 0.41 Published 1998 Journal Br. J. Rheumatol. Section Abstract Doc Link 9487250 Disease Relevance 0.77 Pain Relevance 0.52
The aggrecan/COMP ratio increased in all 9 patients during the 6-month period, indicating increased release of aggrecan relative to COMP fragments.
Positive_regulation (increased) of COMP
3) Confidence 0.40 Published 1997 Journal Eur. J. Oral Sci. Section Abstract Doc Link 9298370 Disease Relevance 0.48 Pain Relevance 0.27
A decrease in circulating COMP—a measurement of ongoing cartilage destruction [19]—occurred after treatment (Figure 5B).
Positive_regulation (circulating) of COMP in cartilage
4) Confidence 0.27 Published 2006 Journal PLoS Medicine Section Body Doc Link PMC1564167 Disease Relevance 1.38 Pain Relevance 0.35
An increased level of COMP in the synovial fluid was described in the early stage of rheumatoid arthritis (RA), whereas in advanced stages of RA, the level of COMP decreased.
Positive_regulation (increased) of COMP in synovial fluid associated with rheumatoid arthritis
5) Confidence 0.21 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15940561 Disease Relevance 0.95 Pain Relevance 0.41
It could be argued that Comp2 was due to activation of a neighboring cell via depolarizing GABA action [49] or electrical coupling [17]; however, the latency was too short to accommodate an intervening synaptic connection, and did not show the variation that would be introduced by the firing of an intervening cell.
Positive_regulation (due) of Comp2 associated with gaba
6) Confidence 0.04 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0.05 Pain Relevance 0.11
In contrast, the D1 agonist SKF38393 facilitated Comp1 with no effect on Comp2' (Figure 7B2).
Neg (no) Positive_regulation (facilitated) of Comp1 associated with agonist
7) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.34
The D2 agonist Quinpirole significantly attenuated Comp1 while modestly facilitating Comp2' (Figure 7B3).
Positive_regulation (facilitating) of Comp2 associated with agonist
8) Confidence 0.03 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1538613 Disease Relevance 0 Pain Relevance 0.33

General Comments

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