INT71274

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Context Info
Confidence 0.12
First Reported 1997
Last Reported 2006
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 0.99
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Acan) cell adhesion (Acan) proteinaceous extracellular matrix (Acan)
Anatomy Link Frequency
tendon 2
cartilage 1
Acan (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Snapping jaw 6 97.44 Very High Very High Very High
imagery 2 93.24 High High
Pain 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Temporomandibular Joint Syndrome 6 97.44 Very High Very High Very High
Osteoarthritis 8 92.40 High High
Tendinopathy 6 71.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSIONS: Increased aggrecan and biglycan mRNA expression in painful tendinopathy resembles the pattern in fibrocartilaginous regions of tendon, and may reflect an altered mechanical environment at the site of the lesion.
Gene_expression (expression) of aggrecan in tendon
1) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16219640 Disease Relevance 0.06 Pain Relevance 0
In painful tendinopathy both aggrecan and biglycan mRNA expression increased (more than 10-fold and 5-fold, respectively) compared with normal tendon samples, but levels of versican and decorin mRNA were not significantly changed.
Gene_expression (expression) of aggrecan in tendon
2) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16219640 Disease Relevance 0.07 Pain Relevance 0
Increased aggrecan mRNA expression may underlie the increase in glycosaminoglycan observed in painful tendinopathy.


Gene_expression (expression) of aggrecan
3) Confidence 0.12 Published 2006 Journal Rheumatology (Oxford) Section Body Doc Link 16219640 Disease Relevance 0 Pain Relevance 0
Aggrecan and COMP were detectable in all but 2 fluids, in which the COMP levels were below detection limit.
Gene_expression (detectable) of Aggrecan
4) Confidence 0.07 Published 1997 Journal Eur. J. Oral Sci. Section Abstract Doc Link 9298370 Disease Relevance 0.49 Pain Relevance 0.27
The purpose was to investigate if antigenic fragments of aggrecan and cartilage oligomeric matrix protein (COMP) are detectable by enzyme-linked immunosorbent assay in lavage fluids from the temporomandibular joint (TMJ) and to examine if the relative content of these cartilage markers changes during development of osteoarthrosis (OA) after diskectomy.
Gene_expression (detectable) of aggrecan in cartilage associated with snapping jaw and osteoarthritis
5) Confidence 0.03 Published 1997 Journal Eur. J. Oral Sci. Section Abstract Doc Link 9298370 Disease Relevance 0.38 Pain Relevance 0.23

General Comments

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