INT71281

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Context Info
Confidence 0.62
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 15
Disease Relevance 5.11
Pain Relevance 1.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9)
Anatomy Link Frequency
endothelial cells 6
body 4
reticulum 4
CPA 2
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
fluoxetine 51 96.76 Very High Very High Very High
cINOD 6 95.44 Very High Very High Very High
noradrenaline 50 74.92 Quite High
Serotonin 72 74.20 Quite High
Potency 7 72.92 Quite High
antidepressant 71 58.04 Quite High
sSRI 83 57.44 Quite High
depression 82 40.60 Quite Low
Versed 4 28.88 Quite Low
ischemia 3 26.12 Quite Low
Disease Link Frequency Relevance Heat
Hypoxia 11 99.98 Very High Very High Very High
Nicotine Addiction 142 99.96 Very High Very High Very High
Hepatocellular Cancer 14 99.60 Very High Very High Very High
Toxicity 14 99.32 Very High Very High Very High
Stress 50 98.56 Very High Very High Very High
Shock 8 95.16 Very High Very High Very High
Cancer 177 91.44 High High
Glioma 19 89.28 High High
Carcinoma 6 86.04 High High
Bronchogenic Carcinoma 4 83.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This result supports data obtained in rats indicating that chronic hypoxia led to an increase in rat CYP2C9 expression in mesenteric arteries.[27] It has also been reported that hypoxia increases the expression of CYP2C mRNAs and proteins and enhanced 11,12-EET production in human endothelial cells.[28] The fact that CYP2C9 mRNA was detected in only 10% of our samples and increased in ischemic hearts may suggest that a certain amount of this mRNA originates from endothelial cells in some but not in other ventricular samples.
Positive_regulation (increases) of Gene_expression (expression) of CYP2C in endothelial cells associated with hypoxia
1) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.25 Pain Relevance 0
This result supports data obtained in rats indicating that chronic hypoxia led to an increase in rat CYP2C9 expression in mesenteric arteries.[27] It has also been reported that hypoxia increases the expression of CYP2C mRNAs and proteins and enhanced 11,12-EET production in human endothelial cells.[28] The fact that CYP2C9 mRNA was detected in only 10% of our samples and increased in ischemic hearts may suggest that a certain amount of this mRNA originates from endothelial cells in some but not in other ventricular samples.
Positive_regulation (increase) of Gene_expression (expression) of CYP2C9 in endothelial cells associated with hypoxia
2) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3001885 Disease Relevance 0.20 Pain Relevance 0
However, the up-regulation of GR fits well to the increased expression of CYP2C9 because GR plays an important role in transcriptional regulation of the CYP2C9 gene (Gerbal-Chaloin et al. 2002).
Positive_regulation (increased) of Gene_expression (expression) of CYP2C9
3) Confidence 0.54 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.64 Pain Relevance 0
In smokers, expression of CYP1A1 (p < 0.05), CYP1B1 (p < 0.001), and CYP2C9 (p < 0.05) was increased (p < 0.05) compared with non-smokers, and there was a trend toward increased expression of CYP3A5 (p = 0.0545; Figure 1); however, the expression of CYP2J2 was significantly (p < 0.05) repressed.
Positive_regulation (increased) of Gene_expression (expression) of CYP2C9 associated with nicotine addiction
4) Confidence 0.39 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1665420 Disease Relevance 0.86 Pain Relevance 0
The drug is widely distributed in the body, with low protein binding and a high volume of distribution (see Table 2).118,119 Following oral absorption, venlafaxine undergoes extensive first-pass hepatic metabolism, where conversion to the active metabolite, desvenlafaxine, occurs via demethylation.157 This reaction is mediated by CYP2D6.120 Desvenlafaxine is further metabolized by CYP3A4.122 Other metabolic pathways for venlafaxine include N-demethylation which is probably mediated by CYP3A4.157 CYP2C9 and CYP2C19 isoenzymes may also be involved in the metabolic pathways of both drugs.121
Positive_regulation (by) of Gene_expression (isoenzymes) of CYP2C9 in body
5) Confidence 0.39 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0 Pain Relevance 0.20
The drug is widely distributed in the body, with low protein binding and a high volume of distribution (see Table 2).118,119 Following oral absorption, venlafaxine undergoes extensive first-pass hepatic metabolism, where conversion to the active metabolite, desvenlafaxine, occurs via demethylation.157 This reaction is mediated by CYP2D6.120 Desvenlafaxine is further metabolized by CYP3A4.122 Other metabolic pathways for venlafaxine include N-demethylation which is probably mediated by CYP3A4.157 CYP2C9 and CYP2C19 isoenzymes may also be involved in the metabolic pathways of both drugs.121
Positive_regulation (by) of Gene_expression (isoenzymes) of CYP2C9 in body
6) Confidence 0.39 Published 2010 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2938284 Disease Relevance 0 Pain Relevance 0.18
Both CYP2C9 overexpression or the administration of 11,12-EET showed increased expression of EphB4 in endothelial cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CYP2C9 in endothelial cells
7) Confidence 0.35 Published 2010 Journal Cancer Metastasis Rev Section Body Doc Link PMC2962793 Disease Relevance 0.05 Pain Relevance 0
Microsomes from cDNA-transfected human lymphoblastoid cells containing human P450-2C9 produced substantial quantities of norfluoxetine when incubated with 100 microM fluoxetine.
Positive_regulation (cDNA-transfected) of Gene_expression (cDNA-transfected) of P450-2C9 associated with fluoxetine
8) Confidence 0.34 Published 1997 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 9298519 Disease Relevance 0 Pain Relevance 0.43
Moreover, activation of Akt was observed in HepG2 cells that overexpress P450 2C9 and might participate in the cellular adaptive response to stress, thus leading to the activation of cell survival pathways.
Positive_regulation (overexpress) of Gene_expression (overexpress) of P450 2C9 associated with stress
9) Confidence 0.34 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.66 Pain Relevance 0.07
P450 2C9 overexpression induced endoplasmic reticulum (ER) stress and regulated genes implicated in the unfolded protein response (UPR) as heat shock protein (HSP) (we studied particurlarly HSPA5 and HSPB1) and in the endoplasmic reticulum associated degradation (ERAD) system as Sec61 and ubiquitin and proteasome pathways.
Positive_regulation (overexpression) of Gene_expression (overexpression) of P450 2C9 in reticulum associated with stress and shock
10) Confidence 0.34 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.40 Pain Relevance 0.09
Genomic consequences of cytochrome P450 2C9 overexpression in human hepatoma cells.
Positive_regulation (overexpression) of Gene_expression (overexpression) of P450 2C9 associated with hepatocellular cancer
11) Confidence 0.34 Published 2009 Journal Chem. Res. Toxicol. Section Title Doc Link 19445531 Disease Relevance 0.35 Pain Relevance 0.09
Our results indicated that P450 2C9 overexpression did not lead to toxicity but induced an ER stress due to protein overexpression rather than mono-oxygenase activity.
Positive_regulation (overexpression) of Gene_expression (overexpression) of P450 2C9 associated with stress and toxicity
12) Confidence 0.34 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.69 Pain Relevance 0.06
P450 2C9 overexpression induced endoplasmic reticulum (ER) stress and regulated genes implicated in the unfolded protein response (UPR) as heat shock protein (HSP) (we studied particurlarly HSPA5 and HSPB1) and in the endoplasmic reticulum associated degradation (ERAD) system as Sec61 and ubiquitin and proteasome pathways.
Positive_regulation (overexpression) of Gene_expression (overexpression) of P450 2C9 in reticulum associated with stress and shock
13) Confidence 0.24 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.40 Pain Relevance 0.09
The aim of this study was to investigate the global cellular consequences of P450 2C9 overexpression at the transcriptional level using an untargeted approach: pangenomic microarrays.
Spec (investigate) Positive_regulation (overexpression) of Spec (investigate) Gene_expression (overexpression) of P450 2C9
14) Confidence 0.24 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.28 Pain Relevance 0.10
AHH-1 human lymphoblastoid cells transfected with CYP2C9 were 5-fold sensitized to CPA compared with the wild-type line (IC50s 0.80 and 4.1?
Positive_regulation (transfected) of Gene_expression (transfected) of CYP2C9 in CPA
15) Confidence 0.21 Published 2003 Journal J Biomed Biotechnol Section Body Doc Link PMC179761 Disease Relevance 0.32 Pain Relevance 0

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