INT71297

Context Info Confidence 0.43 First Reported 1997 Last Reported 2007 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.59 Pain Relevance 0.22

kinase activity (Tk1) cytoplasm (Tk1)

Anatomy Link Frequency TK-1 1 central nervous system 1 Tk1 (Mus musculus)

Pain Link Frequency Relevance Heat Central nervous system 1 98.72 Neurotransmitter 1 95.20 positron emission tomography 24 92.96 Inflammation 4 62.92 Analgesic 1 25.00 Neuropeptide 1 25.00 Action potential 1 25.00 antagonist 1 25.00 imagery 5 5.00 anesthesia 2 5.00

Disease Link Frequency Relevance Heat Cancer 100 88.00 Ganglion Cysts 3 75.44 INFLAMMATION 4 62.92 Hypoxia 1 54.88 Squamous Cell Neoplasms 1 50.00 Recurrence 1 44.64 Head & Neck Cancer 4 5.00 Necrosis 3 5.00 Metastasis 2 5.00 Disease 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a study of Wei et al. [40], an increase in TK-1 activity was found 24 h after irradiation.

Positive_regulation (increase) of TK-1 in TK-1

1) Confidence 0.43 Published 2007 Journal Mol Imaging Biol Section Body Doc Link PMC2040178 Disease Relevance 0.51 Pain Relevance 0.12

Four tachykinin-related peptides, locustatachykinin 1-4 (LomTK 1-4) are distributed in interneurons throughout the central nervous system of the locust Locusta migratoria and may have important roles as neurotransmitters or neuromodulators.

Positive_regulation (distributed) of LomTK 1 in central nervous system associated with neurotransmitter and central nervous system

2) Confidence 0.07 Published 1997 Journal J. Neurobiol. Section Abstract Doc Link 9298767 Disease Relevance 0.08 Pain Relevance 0.10

General Comments

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