INT7130

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Context Info
Confidence 0.80
First Reported 1992
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 32
Total Number 34
Disease Relevance 20.40
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PLA2G2A) extracellular region (PLA2G2A) endoplasmic reticulum (PLA2G2A)
Anatomy Link Frequency
internal 2
plaques 2
microglial cells 1
inferior 1
coronary artery 1
PLA2G2A (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 98.92 Very High Very High Very High
Inflammation 581 98.84 Very High Very High Very High
Chronic pancreatitis 2 98.08 Very High Very High Very High
Arthritis 26 97.28 Very High Very High Very High
Inflammatory mediators 16 97.16 Very High Very High Very High
cytokine 123 96.88 Very High Very High Very High
Inflammatory response 58 95.20 Very High Very High Very High
Kinase C 5 92.84 High High
Pain 8 92.60 High High
Pyramidal cell 10 87.36 High High
Disease Link Frequency Relevance Heat
Coronary Artery Disease 44 100.00 Very High Very High Very High
Atherosclerosis 151 99.88 Very High Very High Very High
Amyloid Plaque 100 99.76 Very High Very High Very High
Cancer 77 99.48 Very High Very High Very High
Inflammatory Bowel Disease 80 99.18 Very High Very High Very High
Sepsis 20 99.04 Very High Very High Very High
Targeted Disruption 15 98.96 Very High Very High Very High
INFLAMMATION 685 98.84 Very High Very High Very High
Adult Respiratory Distress Syndrome 15 98.72 Very High Very High Very High
Pancreatitis 7 98.08 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A stable CHO cell clone, secreting ca 1 mg/L of recombinant PLA2 into the medium, was scaled up in culture to 180 L.
Localization (secreting) of PLA2 in CHO
1) Confidence 0.80 Published 1992 Journal J. Mol. Recognit. Section Abstract Doc Link 1339483 Disease Relevance 0.18 Pain Relevance 0.07
A secreted form of phospholipase A2 (PLA2) is thought to play an important role in inflammatory diseases.
Localization (secreted) of PLA2 associated with inflammation and disease
2) Confidence 0.80 Published 1992 Journal J. Mol. Recognit. Section Abstract Doc Link 1339483 Disease Relevance 0.20 Pain Relevance 0.05
Other studies have also shown that secreted sPLA2-IIA can perturb cellular membranes, especially those undergoing apoptosis [55-57].
Localization (secreted) of sPLA2 associated with apoptosis
3) Confidence 0.80 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.71 Pain Relevance 0.25
Using the same methodology, the number of sPLA2-IIA-positive cells that co-localized with thioflavin S-positive plaques was counted.
Localization (localized) of sPLA2 in plaques
4) Confidence 0.80 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.18 Pain Relevance 0.04
The immunohistochemical localization of group II phospholipase A2 (PLA2) in normal fetal and adult human pancreases, 5 chronic pancreatitis, and 30 pancreatic ductal carcinomas was investigated.
Spec (investigated) Localization (localization) of PLA2 associated with pancreatic ductal carcinoma and chronic pancreatitis
5) Confidence 0.79 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8384235 Disease Relevance 0.72 Pain Relevance 0.15
Since the discovery that mammalian PLA2 is a key enzyme in the release of arachidonic acid, the substrate for the synthesis of several lipid inflammatory mediators, much interest has been focused on this enzyme in the context of inflammation.
Localization (release) of PLA2 associated with inflammatory mediators and inflammation
6) Confidence 0.75 Published 2003 Journal Toxicon Section Abstract Doc Link 15019493 Disease Relevance 0.78 Pain Relevance 0.35
Among more than 20 different forms of PLA2 identified, there is considerable attention on the group IV calcium-dependent cytosolic PLA2 (cPLA2) and the group II secretory PLA2 (sPLA2).
Localization (secretory) of PLA2
7) Confidence 0.74 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.35 Pain Relevance 0.24
Among more than 20 different forms of PLA2 identified, there is considerable attention on the group IV calcium-dependent cytosolic PLA2 (cPLA2) and the group II secretory PLA2 (sPLA2).
Localization (secretory) of sPLA2
8) Confidence 0.74 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.36 Pain Relevance 0.24
Secretory PLA2-IIA has been regarded as an inflammatory protein in the periphery and is upregulated in a number of cardiovascular diseases [25,29,54].
Localization (Secretory) of PLA2 associated with inflammation and cardiovascular disease
9) Confidence 0.74 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.64 Pain Relevance 0.19
 ; ITG, inferior temporal gyrus; GFAP, glial fibrillary acidic protein; ND, non-demented; PBS, phosphate-buffered saline; PCR, polymerase chain reaction; PLA2, phospholipase A2; sPLA2, secretory phospholipase A2.


Localization (secretory) of sPLA2 in inferior
10) Confidence 0.74 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.89 Pain Relevance 0.18
A profound cross-talk between cytosolic phospholipase A2 (cPLA2) and sPLA2-IIA with regard to free radical release has been confirmed by some investigations (Han et al 2003).
Localization (release) of sPLA2-IIA
11) Confidence 0.72 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.45 Pain Relevance 0.04
sPLA2-IIA as a prognostic marker in coronary artery disease
Localization (disease) of sPLA2-IIA in coronary artery associated with coronary artery disease
12) Confidence 0.72 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 1.30 Pain Relevance 0.24
Wang et al. [50] also demonstrated the ability of lipopolysaccharide (LPS) to stimulate and release sPLA2-IIA from astrocytes but not from microglial cells.
Localization (release) of sPLA2 in microglial cells
13) Confidence 0.70 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.64 Pain Relevance 0.25
Immunoreactivity of sPLA2-IIA was also detected in GFAP-positive cells lining the blood vessels (Fig. 1D), and co-localized with amyloid deposits (Fig. 1E).
Localization (localized) of sPLA2 in blood vessels associated with amyloid plaque
14) Confidence 0.70 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.88 Pain Relevance 0.09
As a result of the hydrolytic activity, sPLA2-IIA releases free fatty acids and lyso-phosphatidylcholine(PC) (Yuan et al 1995; Arbibe et al 1998; Fourcade et al 1998; Hurt-Camejo et al 2001; Hurt-Camejo et al 2001).
Localization (releases) of sPLA2-IIA
15) Confidence 0.68 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.28 Pain Relevance 0.04
Secretory sPLA2-IIA cannot be studied in transgenic mouse models of AD due to a frameshift mutation of this gene in many mouse strains [33].
Localization (Secretory) of sPLA2 associated with targeted disruption, sprains and strains and disease
16) Confidence 0.65 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 1.77 Pain Relevance 0.22
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2).
Localization (secretory) of PLA2
17) Confidence 0.62 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.07 Pain Relevance 0.12
LY315920 is a potent, selective inhibitor of recombinant human, group IIA, nonpancreatic secretory PLA2 (sPLA2).
Localization (secretory) of sPLA2
18) Confidence 0.62 Published 1999 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 10027849 Disease Relevance 0.07 Pain Relevance 0.12
Percentages of sPLA2-IIA-positive astrocytes that co-localized with thioflavin S-positive plaques were obtained from the total number of sPLA2-IIA-positive astrocytes.


Localization (localized) of sPLA2 in plaques
19) Confidence 0.61 Published 2006 Journal J Neuroinflammation Section Body Doc Link PMC1613236 Disease Relevance 0.28 Pain Relevance 0.10
Many cell types can secrete sPLA2s, especially sPLA2-IIA such as mesangial cells (Pfeilschifter et al 1989; Schalkwijk et al 1991), vascular smooth muscle (Nakano et al 1990; Kurihara et al 1991), endothelial cells (Murakami et al 1993), platelets (Hayakawa et al 1988), mast cells (Foneth et al 1994; Reddy et al 1996), neutrophils (Wright et al 1990), macrophages (Hidi et al 1993; Brabour et al 1993; Vial et al 1995), and hepatic cells (Crowl et al 1991).
Localization (secrete) of sPLA2-IIA in mesangial cells
20) Confidence 0.59 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2515419 Disease Relevance 0.29 Pain Relevance 0.11

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