INT71305

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 9
Total Number 10
Disease Relevance 5.41
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1)
cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)
Anatomy Link Frequency
macrophage 3
ileum 2
endothelial cell 2
polymorphonuclear leukocyte 1
NFKB1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 5 100.00 Very High Very High Very High
Inflammatory response 12 99.60 Very High Very High Very High
Inflammation 32 98.28 Very High Very High Very High
aspirin 22 97.92 Very High Very High Very High
interstitial cystitis 2 95.36 Very High Very High Very High
chemokine 1 82.12 Quite High
Inflammatory stimuli 1 75.00 Quite High
cytokine 25 65.28 Quite High
anesthesia 2 28.96 Quite Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 48 100.00 Very High Very High Very High
Brain Injury 34 98.64 Very High Very High Very High
Disease 5 97.76 Very High Very High Very High
Blister 4 97.48 Very High Very High Very High
Interstitial Cystitis 2 95.36 Very High Very High Very High
Pressure And Volume Under Development 3 92.24 High High
Osteolysis 2 89.00 High High
Malignant Neoplastic Disease 2 88.56 High High
Parasitic Infection 1 87.68 High High
Cancer 6 87.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, deregulated NF-kappaB expression is a characteristic phenomenon in several inflammatory diseases and NF-kappaB has become a major target in drug discovery.
Regulation (deregulated) of Gene_expression (expression) of NF-kappaB associated with inflammation and disease
1) Confidence 0.61 Published 2009 Journal Inflamm Allergy Drug Targets Section Abstract Doc Link 19275691 Disease Relevance 0.91 Pain Relevance 0.41
We further defined a possible cytoprotective effect of sodium pentosan polysulfate by characterizing the effect of the drug on the expression of nuclear factor kappaB.
Regulation (effect) of Gene_expression (expression) of kappaB
2) Confidence 0.48 Published 2002 Journal J. Urol. Section Abstract Doc Link 12050558 Disease Relevance 0.35 Pain Relevance 0.27
Indeed, deregulated NF-kappaB expression is a characteristic phenomenon in several inflammatory diseases and NF-kappaB has become a major target in drug discovery.
Regulation (deregulated) of Gene_expression (expression) of NF-kappaB associated with inflammation and disease
3) Confidence 0.45 Published 2009 Journal Inflamm Allergy Drug Targets Section Abstract Doc Link 19275691 Disease Relevance 0.91 Pain Relevance 0.41
METHODS: In vitro, zoledronate's effects in modulating soluble vascular endothelial growth factor (VEGF) secretion and receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL) expression were investigated in a feline OSCC cell line (SCCF1).
Spec (investigated) Regulation (effects) of Gene_expression (expression) of NF-kappaB
4) Confidence 0.26 Published 2008 Journal J. Vet. Intern. Med. Section Body Doc Link 18289304 Disease Relevance 0.26 Pain Relevance 0
METHODS: In vitro, zoledronate's effects in modulating soluble vascular endothelial growth factor (VEGF) secretion and receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL) expression were investigated in a feline OSCC cell line (SCCF1).
Regulation (modulating) of Gene_expression (expression) of NF-kappaB
5) Confidence 0.26 Published 2008 Journal J. Vet. Intern. Med. Section Body Doc Link 18289304 Disease Relevance 0.26 Pain Relevance 0
Although not affecting blister fluid volume, aspirin(low) (75 mg, oral, once daily/10 days) reduced polymorphonuclear leukocyte and macrophage accumulation independent of NF-kappaB-regulated gene expression and inhibition of conventional prostanoids.
Neg (independent) Regulation (independent) of Gene_expression (expression) of NF-kappaB-regulated gene in macrophage associated with aspirin and blister
6) Confidence 0.22 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597002 Disease Relevance 0.79 Pain Relevance 0.55
Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.
Regulation (regulating) of Gene_expression (expression) of NF-kappa-B associated with inflammation and cinod
7) Confidence 0.19 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9299399 Disease Relevance 0.70 Pain Relevance 0.18
B p50 expression in ileum was not significantly
Regulation (ileum) of Gene_expression (expression) of p50 in ileum
8) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.43 Pain Relevance 0.07
Although not affecting blister fluid volume, aspirin(low) (75 mg, oral, once daily/10 days) reduced polymorphonuclear leukocyte and macrophage accumulation independent of NF-kappaB-regulated gene expression and inhibition of conventional prostanoids.
Neg (independent) Regulation (independent) of in polymorphonuclear leukocyte Gene_expression (expression) of NF-kappaB-regulated gene in macrophage associated with aspirin and blister
9) Confidence 0.07 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597002 Disease Relevance 0.79 Pain Relevance 0.55
PLC increased endothelial and human umbilical vascular endothelial cell proliferation and rapidly reduced inducible nitric oxide synthase and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells; NADPH-oxidase 4 also regulated NF-kappaB-independent intracellular adhesion molecule-1 expression.
Regulation (regulated) of Gene_expression (expression) of NF-kappaB-independent in endothelial cell
10) Confidence 0.03 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0 Pain Relevance 0

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