INT71305

Context Info Confidence 0.61 First Reported 1997 Last Reported 2010 Negated 2 Speculated 1 Reported most in Abstract Documents 9 Total Number 10 Disease Relevance 5.41 Pain Relevance 2.44

nucleoplasm (NFKB1) mitochondrion (NFKB1) cytoplasm (NFKB1) cytosol (NFKB1) signal transduction (NFKB1) nucleolus (NFKB1)

Anatomy Link Frequency macrophage 3 ileum 2 endothelial cell 2 polymorphonuclear leukocyte 1 NFKB1 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 5 100.00 Inflammatory response 12 99.60 Inflammation 32 98.28 aspirin 22 97.92 interstitial cystitis 2 95.36 chemokine 1 82.12 Inflammatory stimuli 1 75.00 cytokine 25 65.28 anesthesia 2 28.96 palliative 2 5.00

Disease Link Frequency Relevance Heat INFLAMMATION 48 100.00 Brain Injury 34 98.64 Disease 5 97.76 Blister 4 97.48 Interstitial Cystitis 2 95.36 Pressure And Volume Under Development 3 92.24 Osteolysis 2 89.00 Malignant Neoplastic Disease 2 88.56 Parasitic Infection 1 87.68 Cancer 6 87.16

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Key:

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Mutation

Event

Anatomy

Negation

Speculation

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Disease term

Indeed, deregulated NF-kappaB expression is a characteristic phenomenon in several inflammatory diseases and NF-kappaB has become a major target in drug discovery.

Regulation (deregulated) of Gene_expression (expression) of NF-kappaB associated with inflammation and disease

1) Confidence 0.61 Published 2009 Journal Inflamm Allergy Drug Targets Section Abstract Doc Link 19275691 Disease Relevance 0.91 Pain Relevance 0.41

We further defined a possible cytoprotective effect of sodium pentosan polysulfate by characterizing the effect of the drug on the expression of nuclear factor kappaB.

Regulation (effect) of Gene_expression (expression) of kappaB

2) Confidence 0.48 Published 2002 Journal J. Urol. Section Abstract Doc Link 12050558 Disease Relevance 0.35 Pain Relevance 0.27

Indeed, deregulated NF-kappaB expression is a characteristic phenomenon in several inflammatory diseases and NF-kappaB has become a major target in drug discovery.

Regulation (deregulated) of Gene_expression (expression) of NF-kappaB associated with inflammation and disease

3) Confidence 0.45 Published 2009 Journal Inflamm Allergy Drug Targets Section Abstract Doc Link 19275691 Disease Relevance 0.91 Pain Relevance 0.41

METHODS: In vitro, zoledronate's effects in modulating soluble vascular endothelial growth factor (VEGF) secretion and receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL) expression were investigated in a feline OSCC cell line (SCCF1).

Spec (investigated) Regulation (effects) of Gene_expression (expression) of NF-kappaB

4) Confidence 0.26 Published 2008 Journal J. Vet. Intern. Med. Section Body Doc Link 18289304 Disease Relevance 0.26 Pain Relevance 0

METHODS: In vitro, zoledronate's effects in modulating soluble vascular endothelial growth factor (VEGF) secretion and receptor activator of nuclear factor kappaB (NF-kappaB) ligand (RANKL) expression were investigated in a feline OSCC cell line (SCCF1).

Regulation (modulating) of Gene_expression (expression) of NF-kappaB

5) Confidence 0.26 Published 2008 Journal J. Vet. Intern. Med. Section Body Doc Link 18289304 Disease Relevance 0.26 Pain Relevance 0

Although not affecting blister fluid volume, aspirin(low) (75 mg, oral, once daily/10 days) reduced polymorphonuclear leukocyte and macrophage accumulation independent of NF-kappaB-regulated gene expression and inhibition of conventional prostanoids.

Neg (independent) Regulation (independent) of Gene_expression (expression) of NF-kappaB-regulated gene in macrophage associated with aspirin and blister

6) Confidence 0.22 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597002 Disease Relevance 0.79 Pain Relevance 0.55

Among the regulatory promoter elements potentially regulating eotaxin gene expression and/or mediating the effects of anti-inflammatory drugs we identified consensus sequences known to interact with nuclear factors like NF-IL6, AP-1, a NF-kappa-B like consensus sequence and gamma-interferon- as well as glucocorticoid response elements.

Regulation (regulating) of Gene_expression (expression) of NF-kappa-B associated with inflammation and cinod

7) Confidence 0.19 Published 1997 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 9299399 Disease Relevance 0.70 Pain Relevance 0.18

B p50 expression in ileum was not significantly

Regulation (ileum) of Gene_expression (expression) of p50 in ileum

8) Confidence 0.09 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2222592 Disease Relevance 0.43 Pain Relevance 0.07

Although not affecting blister fluid volume, aspirin(low) (75 mg, oral, once daily/10 days) reduced polymorphonuclear leukocyte and macrophage accumulation independent of NF-kappaB-regulated gene expression and inhibition of conventional prostanoids.

Neg (independent) Regulation (independent) of in polymorphonuclear leukocyte Gene_expression (expression) of NF-kappaB-regulated gene in macrophage associated with aspirin and blister

9) Confidence 0.07 Published 2009 Journal J. Immunol. Section Abstract Doc Link 19597002 Disease Relevance 0.79 Pain Relevance 0.55

PLC increased endothelial and human umbilical vascular endothelial cell proliferation and rapidly reduced inducible nitric oxide synthase and NADPH-oxidase 4-mediated reactive oxygen species production in human umbilical vascular endothelial cells; NADPH-oxidase 4 also regulated NF-kappaB-independent intracellular adhesion molecule-1 expression.

Regulation (regulated) of Gene_expression (expression) of NF-kappaB-independent in endothelial cell

10) Confidence 0.03 Published 2010 Journal Arterioscler. Thromb. Vasc. Biol. Section Body Doc Link 20056909 Disease Relevance 0 Pain Relevance 0

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